CEP135

CEP135
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5FCN
Identifiers
Aliases	CEP135 , CEP4, KIAA0635, MCPH8, centrosomal protein 135
External IDs	OMIM: 611423; MGI: 2681869; HomoloGene: 45709; GeneCards: CEP135; OMA:CEP135 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4q12 Start 55,948,871 bp [1] End 56,033,361 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 C3.3 Start 76,736,545 bp [2] End 76,794,313 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in amniotic fluid buccal mucosa cell sperm ventricular zone testicle gonad bone marrow monocyte Achilles tendon secondary oocyte Top expressed in zygote genital tubercle tail of embryo secondary oocyte spermatid spermatocyte granulocyte ventricular zone primary oocyte epiblast More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein C-terminus binding protein binding Cellular component cytoplasm centriole cytosol centrosome cytoskeleton Biological process centriole replication centriole-centriole cohesion G2/M transition of mitotic cell cycle positive regulation of non-motile cilium assembly ciliary basal body-plasma membrane docking regulation of G2/M transition of mitotic cell cycle positive regulation of establishment of protein localization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9662 381644 Ensembl ENSG00000174799 ENSMUSG00000036403 UniProt Q66GS9 Q6P5D4 RefSeq (mRNA) NM_014645 NM_025009 NM_199032 RefSeq (protein) NP_079285 NP_950197 Location (UCSC) Chr 4: 55.95 – 56.03 Mb Chr 5: 76.74 – 76.79 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Centrosomal protein of 135 kDa is a protein that in humans is encoded by the CEP135 gene. ^{[5] [6] [7]} It is part of the centrosome throughout the cell cycle, being distributed in the pericentriolar material. ^[8] CEP135 is required for the centriolar localization of CEP250. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000174799 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036403 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi: 10.1093/dnares/5.3.169 . PMID   9734811.
6. Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (Dec 2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. Bibcode:2003Natur.426..570A. doi:10.1038/nature02166. PMID   14654843. S2CID   4427303.
7. "Entrez Gene: CEP135 centrosomal protein 135kDa".
8. Ohta T, Essner R, Ryu JH, Palazzo RE, Uetake Y, Kuriyama R (January 2002). "Characterization of Cep135, a novel coiled-coil centrosomal protein involved in microtubule organization in mammalian cells". J. Cell Biol. 156 (1): 87–99. doi:10.1083/jcb.200108088. PMC   2173569 . PMID   11781336.
9. Kim K, Lee S, Chang J, Rhee K (December 2008). "A novel function of CEP135 as a platform protein of C-NAP1 for its centriolar localization". Exp. Cell Res. 314 (20): 3692–700. doi:10.1016/j.yexcr.2008.09.016. PMID   18851962.

External links

• Human CEP135 genome location and CEP135 gene details page in the UCSC Genome Browser .
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Centrosomal protein of 135 kDa

Further reading

• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.