CNTROB

CNTROB
Identifiers
Aliases	CNTROB , LIP8, PP1221, centrobin, centriole duplication and spindle assembly protein
External IDs	OMIM: 611425 MGI: 2443290 HomoloGene: 14205 GeneCards: CNTROB
Gene location (Human)
Chr.	Chromosome 17 (human)
End	7,949,920 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	69,323,775 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; right lung; ; upper lobe of left lung; ; pancreatic ductal cell; ; canal of the cervix; ; right lobe of thyroid gland; ; right uterine tube; ; smooth muscle tissue; ; left lobe of thyroid gland; ; anterior pituitary;
	Top expressed in
	superior surface of tongue; ; gallbladder; ; secondary oocyte; ; spermatocyte; ; thymus; ; saccule; ; ganglionic eminence; ; otic placode; ; submandibular gland; ; right ventricle;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ; protein domain specific binding ;
Cellular component	centriole ; centrosome ; cytoskeleton ; cytoplasm ; cytosol ;
Biological process	cell cycle ; mitotic cytokinetic process ; centrosome separation ; cell division ; centriole replication ; regulation of cilium assembly ;
	Sources:Amigo / QuickGO
Orthologs
	116840
	216846
	ENSG00000170037
	ENSMUSG00000032782
	Q8N137
	Q8CB62
NM_001037144 ; NM_053051 ; NM_001330124 ; NM_001353202 ; NM_001353203 ;
	NM_001353204 ; NM_001353205 ; NM_001353206 ; NM_001353207 ; NM_001353208 ; NM_001353209 Contents References ; External links ; Further reading ;
	NM_172560
NP_001032221 ; NP_001317053 ; NP_444279 ; NP_001340131 ; NP_001340132 ;
	NP_001340133 ; NP_001340134 ; NP_001340135 ; NP_001340136 ; NP_001340137 ; NP_001340138
	NP_766148
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 05, 2023

Centrobin is a protein that in humans is encoded by the CNTROB gene.^[5] It is a centriole-associated protein that asymmetrically localizes to the daughter centriole, and is required for centriole duplication and cytokinesis.^[6]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000170037 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032782 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Tchernev, V. T.; Mansfield, T. A.; Giot, L.; Kumar, A. M.; Nandabalan, K.; Li, Y.; Mishra, V. S.; Detter, J. C.; Rothberg, J. M.; Wallace, M. R.; Southwick, F. S.; Kingsmore, S. F. (2002). "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins". Molecular Medicine. 8 (1): 56–64. doi:10.1007/bf03402003. PMC 2039936 . PMID 11984006.
↑ Zou, C.; Li, J.; Bai, Y.; Gunning, W.; Wazer, D.; Band, V.; Gao, Q. (2005). "Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication". Journal of Cell Biology . 171 (3): 437–445. doi:10.1083/jcb.200506185. PMC 2171251 . PMID 16275750.

External links

Human CNTROB genome location and CNTROB gene details page in the UCSC Genome Browser .

Jeong Y, Lee J, Kim K, et al. (2007). "Characterization of NIP2/centrobin, a novel substrate of Nek2, and its potential role in microtubule stabilization". J. Cell Sci. 120 (Pt 12): 2106–16. doi: 10.1242/jcs.03458 . PMID 17535851.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID 16713569. S2CID 13709685.
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi: 10.1073/pnas.0404089101 . PMC 524842 . PMID 15498874.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000170037 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032782 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11984006-5] Tchernev, V. T.; Mansfield, T. A.; Giot, L.; Kumar, A. M.; Nandabalan, K.; Li, Y.; Mishra, V. S.; Detter, J. C.; Rothberg, J. M.; Wallace, M. R.; Southwick, F. S.; Kingsmore, S. F. (2002). "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins". Molecular Medicine. 8 (1): 56–64. doi:10.1007/bf03402003. PMC 2039936 . PMID 11984006.

[6] Zou, C.; Li, J.; Bai, Y.; Gunning, W.; Wazer, D.; Band, V.; Gao, Q. (2005). "Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication". Journal of Cell Biology . 171 (3): 437–445. doi:10.1083/jcb.200506185. PMC 2171251 . PMID 16275750.

[1]

[2]

[3]

[4]

[5]

[6]

v t e The centrosome and its components
Centrioles	SASS6 CENPJ CNTROB CEP104 Centrins (CETN1, CETN2 and CETN3) SFI1
Pericentriolar material	BBS4 Lck PCM1 PCNT TNKS TNKS2 TUBE1
other proteins	CCP110 CEP55 CEP57 CEP63 CEP68 CEP70 CEP72 CEP76 CEP78 CEP90 CEP97 CEP120 CEP135 CEP152 CEP164 CEP170 CEP192 CEP215 CEP250 CEP350 CNTRL NIN NINL

CNTROB

Contents

Related Research Articles

References

External links

Further reading