CEP55

CEP55
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3E1R, 3WUT, 3WUU, 3WUV
Identifiers
Aliases	CEP55 , C10orf3, CT111, URCC6, centrosomal protein 55, MARCH
External IDs	OMIM: 610000; MGI: 1921357; HomoloGene: 10019; GeneCards: CEP55; OMA:CEP55 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q23.33 Start 93,496,612 bp [1] End 93,529,092 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19|19 C2 Start 38,043,459 bp [2] End 38,062,871 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle ventricular zone gonad secondary oocyte sperm ganglionic eminence stromal cell of endometrium rectum gingival epithelium mucosa of transverse colon Top expressed in primary oocyte zygote secondary oocyte endothelial cell of lymphatic vessel spermatocyte cumulus cell atrioventricular valve medial ganglionic eminence abdominal wall ventricular zone More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component cytoplasm centriole centrosome cleavage furrow cytoskeleton membrane intercellular bridge midbody microtubule organizing center plasma membrane Flemming body Biological process cell division cell cycle septum digestion after cytokinesis mitotic cytokinesis mitotic metaphase plate congression nucleus organization establishment of protein localization renal system development cranial skeletal system development multicellular organism development regulation of phosphatidylinositol 3-kinase signaling midbody abscission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55165 74107 Ensembl ENSG00000138180 ENSMUSG00000024989 UniProt Q53EZ4 Q8BT07 RefSeq (mRNA) NM_001127182 NM_018131 NM_001164362 NM_028293 NM_028760 NM_001360663 RefSeq (protein) NP_001120654 NP_060601 NP_001157834 NP_082569 NP_083036 NP_001347592 Location (UCSC) Chr 10: 93.5 – 93.53 Mb Chr 19: 38.04 – 38.06 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Centrosomal protein of 55 kDa(Cep55), is a protein that in humans is encoded by the CEP55 gene. ^{[5] [6]}

Cep55 is a mitotic phosphoprotein that plays a key role in cytokinesis, the final stage of cell division. ^[7] and cilia formation in neural stem cells. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000138180 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024989 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Fabbro M, Zhou BB, Takahashi M, Sarcevic B, Lal P, Graham ME, Gabrielli BG, Robinson PJ, Nigg EA, Ono Y, Khanna KK (Oct 2005). "Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis". Dev Cell. 9 (4): 477–88. doi: 10.1016/j.devcel.2005.09.003 . PMID   16198290.
6. "Entrez Gene: CEP55 centrosomal protein 55kDa".
7. van der Horst A, Simmons J, Khanna KK (November 2009). "Cep55 stabilization is required for normal execution of cytokinesis". Cell Cycle. 8 (22): 3742–3749. doi: 10.4161/cc.8.22.10047 . PMID   19855176.
8. Behnam Rashidieh; Belal Shohayeb; Amanda Louise Bain; Patrick R. J. Fortuna; Debottam Sinha; Andrew Burgess; Richard Mills; Rachael C. Adams; J. Alejandro Lopez; Peter Blumbergs; John Finnie; Murugan Kalimutho; Michael Piper; James Edward Hudson; Dominic C. H. Ng; Kum Kum Khanna (October 2021). "Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis". PLOS Genetics. 17 (10) e1009334. doi: 10.1371/journal.pgen.1009334 . PMC   8577787 . PMID   34710087.

External links

• Human CEP55 genome location and CEP55 gene details page in the UCSC Genome Browser .

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi: 10.1038/nature02462 . PMID   15164054.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Martinez-Garay I, Rustom A, Gerdes HH, Kutsche K (2006). "The novel centrosomal associated protein CEP55 is present in the spindle midzone and the midbody". Genomics. 87 (2): 243–53. doi: 10.1016/j.ygeno.2005.11.006 . PMID   16406728.
• Zhao WM, Seki A, Fang G (2006). "Cep55, a Microtubule-bundling Protein, Associates with Centralspindlin to Control the Midbody Integrity and Cell Abscission during Cytokinesis". Mol. Biol. Cell. 17 (9): 3881–96. doi:10.1091/mbc.E06-01-0015. PMC   1593165 . PMID   16790497.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Chen CH, Lu PJ, Chen YC, et al. (2007). "FLJ10540-elicited cell transformation is through the activation of PI3-kinase/AKT pathway". Oncogene. 26 (29): 4272–83. doi: 10.1038/sj.onc.1210207 . PMID   17237822.
• Carlton JG, Martin-Serrano J (2007). "Parallels between cytokinesis and retroviral budding: a role for the ESCRT machinery". Science. 316 (5833): 1908–12. Bibcode:2007Sci...316.1908C. doi: 10.1126/science.1143422 . PMID   17556548. S2CID   29191843.
• Morita E, Sandrin V, Chung HY, et al. (2007). "Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis". EMBO J. 26 (19): 4215–27. doi:10.1038/sj.emboj.7601850. PMC   2230844 . PMID   17853893.