CNTRL

For other uses, see CNTRL (disambiguation).

CNTRL
Identifiers
Aliases	CNTRL , CEP1, CEP110, FAN, bA165P4.1, centriolin
External IDs	OMIM: 605496 MGI: 1889576 HomoloGene: 38260 GeneCards: CNTRL
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q33.2 Start 121,074,660 bp [1] End 121,177,729 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 B Start 35,109,492 bp [2] End 35,178,822 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon secondary oocyte bronchial epithelial cell sural nerve sperm monocyte right uterine tube bone marrow cells lymph node superficial temporal artery Top expressed in spermatocyte thymus spermatid spleen blood seminiferous tubule ganglionic eminence left lobe of liver bone marrow submandibular gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein tyrosine kinase activity cytoskeletal protein binding Cellular component microtubule organizing center centrosome cytoskeleton membrane cytoplasm cytosol midbody Flemming body centriolar subdistal appendage Biological process cell division cell cycle G2/M transition of mitotic cell cycle peptidyl-tyrosine phosphorylation mitotic cell cycle ciliary basal body-plasma membrane docking regulation of G2/M transition of mitotic cell cycle regulation of cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11064 26920 Ensembl ENSG00000119397 ENSMUSG00000057110 UniProt Q7Z7A1 A2AL36 RefSeq (mRNA) NM_007018 NM_001330762 NM_001369892 NM_001369893 NM_001369894 NM_001369895 NM_001369896 NM_001290635 NM_012018 NM_030000 NM_001379274 NM_001379275 RefSeq (protein) NP_001317691 NP_008949 NP_001356821 NP_001356822 NP_001356823 NP_001356824 NP_001356825 NP_001277564 NP_036148 NP_001366203 NP_001366204 Location (UCSC) Chr 9: 121.07 – 121.18 Mb Chr 2: 35.11 – 35.18 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Centriolin is a protein that in humans is encoded by the CNTRL gene. It was previously known as CEP110. ^{[5] [6]}

This gene encodes a centrosomal protein required for the centrosome to function as a microtubule organizing center. The gene product is also associated with centrosome maturation. One version of stem cell myeloproliferative disorder is the result of a reciprocal translocation between chromosomes 8 and 9, with the breakpoint associated with fibroblast growth factor receptor 1 and centriolin. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000119397 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000057110 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Guasch G, Mack GJ, Popovici C, Dastugue N, Birnbaum D, Rattner JB, Pebusque MJ (Mar 2000). "FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33)". Blood. 95 (5): 1788–96. doi:10.1182/blood.V95.5.1788.005k15_1788_1796. PMID   10688839.
6. "Entrez Gene: CEP110 centrosomal protein 110kDa".

External links

• Human CNTRL genome location and CNTRL gene details page in the UCSC Genome Browser .

Further reading

• Gromley A, Yeaman C, Rosa J, et al. (2005). "Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscission". Cell. 123 (1): 75–87. doi: 10.1016/j.cell.2005.07.027 . PMID   16213214. S2CID   6665005.
• Guinn BA, Bland EA, Lodi U, et al. (2005). "Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia". Biochem. Biophys. Res. Commun. 335 (4): 1293–304. doi:10.1016/j.bbrc.2005.08.024. PMID   16112646.
• Jurczyk A, Gromley A, Redick S, et al. (2004). "Pericentrin forms a complex with intraflagellar transport proteins and polycystin-2 and is required for primary cilia assembly". J. Cell Biol. 166 (5): 637–43. doi:10.1083/jcb.200405023. PMC   2172416 . PMID   15337773.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gromley A, Jurczyk A, Sillibourne J, et al. (2003). "A novel human protein of the maternal centriole is required for the final stages of cytokinesis and entry into S phase". J. Cell Biol. 161 (3): 535–45. doi:10.1083/jcb.200301105. PMC   2172935 . PMID   12732615.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ou YY, Mack GJ, Zhang M, Rattner JB (2002). "CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation". J. Cell Sci. 115 (Pt 9): 1825–35. doi:10.1242/jcs.115.9.1825. PMID   11956314.
• Popovici C, Mattéi MG, Rattner JB, et al. (2000). "Assignment of the centrosomal protein 110 gene (Cep110) to mouse chromosome bands 2B-C1 by in situ hybridization". Cytogenet. Cell Genet. 89 (3–4): 216–7. doi:10.1159/000015616. PMID   10965126. S2CID   31717030.
• Osaki E, Nishina Y, Inazawa J, et al. (1999). "Identification of a novel Sry-related gene and its germ cell-specific expression". Nucleic Acids Res. 27 (12): 2503–10. doi:10.1093/nar/27.12.2503. PMC   148454 . PMID   10359848.
• Schütze S, Machleidt T, Adam D, et al. (1999). "Inhibition of receptor internalization by monodansylcadaverine selectively blocks p55 tumor necrosis factor receptor death domain signaling". J. Biol. Chem. 274 (15): 10203–12. doi: 10.1074/jbc.274.15.10203 . PMID   10187805.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.