CNTRL

Last updated
CNTRL
Identifiers
Aliases CNTRL , CEP1, CEP110, FAN, bA165P4.1, centriolin
External IDs OMIM: 605496; MGI: 1889576; HomoloGene: 38260; GeneCards: CNTRL; OMA:CNTRL - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001290635
NM_012018
NM_030000
NM_001379274
NM_001379275

Contents

RefSeq (protein)

NP_001277564
NP_036148
NP_001366203
NP_001366204

Location (UCSC) Chr 9: 121.07 – 121.18 Mb Chr 2: 35.11 – 35.18 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Centriolin is a protein that in humans is encoded by the CNTRL gene. It was previously known as CEP110. [5] [6]

This gene encodes a centrosomal protein required for the centrosome to function as a microtubule organizing center. The gene product is also associated with centrosome maturation. One version of stem cell myeloproliferative disorder is the result of a reciprocal translocation between chromosomes 8 and 9, with the breakpoint associated with fibroblast growth factor receptor 1 and centriolin. [6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000119397 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000057110 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Guasch G, Mack GJ, Popovici C, Dastugue N, Birnbaum D, Rattner JB, Pebusque MJ (Mar 2000). "FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33)". Blood. 95 (5): 1788–96. doi:10.1182/blood.V95.5.1788.005k15_1788_1796. PMID   10688839.
  6. 1 2 "Entrez Gene: CEP110 centrosomal protein 110kDa".

Further reading