CEP164

Last updated
CEP164
Identifiers
Aliases CEP164 , NPHP15, centrosomal protein 164
External IDs OMIM: 614848 MGI: 2384878 HomoloGene: 51110 GeneCards: CEP164
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001271933
NM_014956

NM_001081373

RefSeq (protein)

NP_001258862
NP_055771

n/a

Location (UCSC) Chr 11: 117.31 – 117.41 Mb Chr 9: 45.68 – 45.74 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Centrosomal protein of 164 kDa, also known as CEP164, is a protein that in humans is encoded by the CEP164 gene. [5] [6] Its function appears two be twofold: CEP164 is required for primary cilium formation. [7] Furthermore, it is an important component in the response to DNA damage by UV light. [8] [9]

Contents

Related Research Articles

<span class="mw-page-title-main">Centrosome</span> Cell organelle in animal cell helping in cell division

In cell biology, the centrosome is an organelle that serves as the main microtubule organizing center (MTOC) of the animal cell, as well as a regulator of cell-cycle progression. The centrosome provides structure for the cell. The centrosome is thought to have evolved only in the metazoan lineage of eukaryotic cells. Fungi and plants lack centrosomes and therefore use other structures to organize their microtubules. Although the centrosome has a key role in efficient mitosis in animal cells, it is not essential in certain fly and flatworm species.

<span class="mw-page-title-main">Aurora kinase A</span> Protein-coding gene in the species Homo sapiens

Aurora kinase A also known as serine/threonine-protein kinase 6 is an enzyme that in humans is encoded by the AURKA gene.

<span class="mw-page-title-main">PCM1</span> Protein-coding gene in the species Homo sapiens

Pericentriolar material 1, also known as PCM1, is a protein which in humans is encoded by the PCM1 gene.

<span class="mw-page-title-main">NEK2</span> Protein-coding gene in the species Homo sapiens

Serine/threonine-protein kinase Nek2 is an enzyme that in humans is encoded by the NEK2 gene.

<span class="mw-page-title-main">Ninein</span> Ninein (s.m. Al Ninein) in dialetto Bolognese è il maiale.

Ninein is a protein that in humans is encoded by the NIN gene.

<span class="mw-page-title-main">CNTRL</span> Protein-coding gene in the species Homo sapiens

Centriolin is a protein that in humans is encoded by the CNTRL gene. It was previously known as CEP110.

<span class="mw-page-title-main">CEP250</span> Protein-coding gene in the species Homo sapiens

Centrosome-associated protein CEP250 is a protein that in humans is encoded by the CEP250 gene. This gene encodes a core centrosomal protein required for centriole-centriole cohesion during interphase of the cell cycle. The encoded protein dissociates from the centrosomes when parental centrioles separate at the beginning of mitosis. The protein associates with and is phosphorylated by NIMA-related kinase 2, which is also associated with the centrosome. Furthermore, CEP135 is also required for the centriolar localization of CEP250.

<span class="mw-page-title-main">TUBG2</span> Protein-coding gene in the species Homo sapiens

Tubulin gamma-2 chain is a protein that in humans is encoded by the TUBG2 gene.

<span class="mw-page-title-main">CEP170</span> Protein-coding gene in the species Homo sapiens

Centrosomal protein 170kDa, also known as CEP170, is a protein that in humans is encoded by the CEP170 gene.

<span class="mw-page-title-main">CCP110</span> Protein-coding gene in the species Homo sapiens

Centriolar coiled-coil protein of 110 kDa also known as centrosomal protein of 110 kDa or CP110 is a protein that in humans is encoded by the CCP110 gene. It is a cell cycle-dependent CDK substrate and regulates centrosome duplication. CP110 suppresses a cilia assembly program.

<span class="mw-page-title-main">TUBGCP3</span> Protein-coding gene in the species Homo sapiens

Gamma-tubulin complex component 3 is a protein that in humans is encoded by the TUBGCP3 gene. It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.

<span class="mw-page-title-main">CEP135</span> Protein-coding gene in the species Homo sapiens

Centrosomal protein of 135 kDa is a protein that in humans is encoded by the CEP135 gene. It is part of the centrosome throughout the cell cycle, being distributed in the pericentriolar material. CEP135 is required for the centriolar localization of CEP250.

<span class="mw-page-title-main">Rootletin</span> Protein-coding gene in the species Homo sapiens

Rootletin also known as ciliary rootlet coiled-coil protein (CROCC) is a protein that in humans is encoded by the CROCC gene. Rootletin is a component of the ciliary rootlet, and, together with CEP68 and CEP250, is required for centrosome cohesion.

<span class="mw-page-title-main">NEDD1</span> Protein-coding gene in the species Homo sapiens

Neural precursor cell expressed, developmentally down-regulated 1, also known as Nedd1, is a human gene and encodes the protein NEDD1.

<span class="mw-page-title-main">CEP192</span> Protein-coding gene in the species Homo sapiens

Centrosomal protein of 192 kDa, also known as Cep192, is a protein that in humans is encoded by the CEP192 gene. It is the homolog of the C. elegans and D. melanogaster gene SPD-2.

<span class="mw-page-title-main">CEP76</span> Protein-coding gene in the species Homo sapiens

Centrosomal protein of 76 kDa, also known as CEP76, is a protein that in humans is encoded by the CEP76 gene.

<span class="mw-page-title-main">CEP78</span> Protein-coding gene in the species Homo sapiens

Centrosomal protein of 78 kDa, also known as Cep78, is a protein that in humans is encoded by the CEP78 gene.

<span class="mw-page-title-main">CEP152</span> Protein-coding gene in the species Homo sapiens

Centrosomal protein of 152 kDa, also known as Cep152, is a protein that in humans is encoded by the CEP152 gene. It is the ortholog of the Drosophila melanogaster gene asterless (asl) and both are required for centriole duplication.

<span class="mw-page-title-main">HOOK2</span> Protein-coding gene in the species Homo sapiens

Protein Hook homolog 2 (HK2) is a protein that in humans is encoded by the HOOK2 gene.

<span class="mw-page-title-main">SFI1</span> Protein-coding gene in the species Homo sapiens

Sfi1 homolog, spindle assembly associated (yeast) is a protein that in humans is encoded by the SFI1 gene. It localizes to the centriole, and its S. pombe ortholog has been shown to be involved in spindle pole body duplication. SFI1 forms a complex with centrin 2.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000110274 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000043987 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: centrosomal protein 164kDa".
  6. Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (December 2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. Bibcode:2003Natur.426..570A. doi:10.1038/nature02166. PMID   14654843. S2CID   4427303.
  7. Graser, S.; Stierhof, Y. -D.; Lavoie, S. B.; Gassner, O. S.; Lamla, S.; Le Clech, M.; Nigg, E. A. (2007). "Cep164, a novel centriole appendage protein required for primary cilium formation". The Journal of Cell Biology. 179 (2): 321–30. doi:10.1083/jcb.200707181. PMC   2064767 . PMID   17954613.
  8. Sivasubramaniam, S.; Sun, X.; Pan, Y. -R.; Wang, S.; Lee, E. Y. -H. P. (2008). "Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1". Genes & Development. 22 (5): 587–600. doi:10.1101/gad.1627708. PMC   2259029 . PMID   18283122.
  9. Pan, YR; Lee, EY (2009). "UV-dependent interaction between Cep164 and XPA mediates localization of Cep164 at sites of DNA damage and UV sensitivity". Cell Cycle. 8 (4): 655–64. doi: 10.4161/cc.8.4.7844 . PMID   19197159.

Further reading