IM-250

Last updated
IM-250
IM-250.svg
Names
IUPAC name
(S)-2-[4-(2,5-difluorophenyl)phenyl]-N-methyl-N-[4-methyl-5-(methylsulfonimidoyl)-1,3-thiazol-2-yl]acetamide
Identifiers
3D model (JSmol)
ChemSpider
PubChem CID
  • InChI=1S/C20H19F2N3O2S2/c1-12-19(29(3,23)27)28-20(24-12)25(2)18(26)10-13-4-6-14(7-5-13)16-11-15(21)8-9-17(16)22/h4-9,11,23H,10H2,1-3H3
    Key: JDZTWDISDHLKCR-UHFFFAOYSA-N
  • CC1=C(SC(=N1)N(C)C(=O)CC2=CC=C(C=C2)C3=C(C=CC(=C3)F)F)S(=N)(=O)C
Properties
C20H19F2N3O2S2
Molar mass 435.51 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

IM-250 is an anti-herpetic drug candidate [1] developed by Innovative Molecules Gmbh. [2] The drug was conceived by a chemist at the company, who hypothesized that swapping the sulfonamide functional group of pritelivir for a sulfoximine would reduce off-target effects. In addition, the pyridine ring on pritelivir was changed to a 2,5-difluorobenzene ring to make the drug candidate more likely to enter the central nervous system as herpes can lie dormant within neurons. [3]

Innovative Molecules raised 20 million euro for clinical trials on humans. [4]

See also

References

  1. ↑ Gege, Christian; Bravo, Fernando J.; Uhlig, Nadja; Hagmaier, Timo; Schmachtenberg, Rosanne; Elis, Julia; Burger-Kentischer, Anke; Finkelmeier, Doris; Hamprecht, Klaus; Grunwald, Thomas; Bernstein, David I.; Kleymann, Gerald (16 June 2021). "A helicase-primase drug candidate with sufficient target tissue exposure affects latent neural herpes simplex virus infections". Science Translational Medicine. 13 (598) eabf8668. doi:10.1126/scitranslmed.abf8668. PMID   34135112.
  2. ↑ "Drug Candidate Shows 'Potent Anti-Herpes Activity'". 17 June 2021.
  3. ↑ "Small molecule fights active and latent herpes infections in rodents". 21 January 2025.
  4. ↑ Lücking, Ulrich (7 October 2022). "New Opportunities for the Utilization of the Sulfoximine Group in Medicinal Chemistry from the Drug Designer's Perspective" . Chemistry – A European Journal. 28 (56) e202201993. Bibcode:2022ChEuJ..28E1993L. doi:10.1002/chem.202201993. PMID   35789054.


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