IMP3

IMP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CQJ
Identifiers
Aliases	IMP3 , BRMS2, C15orf12, MRPS4, U3 small nucleolar ribonucleoprotein, IMP U3 small nucleolar ribonucleoprotein 3
External IDs	OMIM: 612980 MGI: 1916119 HomoloGene: 6120 GeneCards: IMP3
Gene location (Human) Chr. Chromosome 15 (human) [1] Band 15q24.2 Start 75,639,085 bp [1] End 75,648,706 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 B Start 56,844,759 bp [2] End 56,845,682 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen right lobe of liver right adrenal gland left adrenal gland spleen gastrocnemius muscle nipple cerebellar vermis body of stomach nucleus accumbens Top expressed in medial ganglionic eminence condyle fossa lip endocardial cushion parotid gland renal corpuscle islet of Langerhans thymus calvaria More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of ribosome rRNA binding protein binding snoRNA binding RNA binding Cellular component small ribosomal subunit small-subunit processome Mpp10 complex nucleolus intracellular anatomical structure nucleus nucleoplasm preribosome Biological process positive regulation of translational fidelity ribosome biogenesis rRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55272 102462 Ensembl ENSG00000177971 ENSMUSG00000032288 UniProt Q9NV31 Q921Y2 RefSeq (mRNA) NM_018285 NM_133976 RefSeq (protein) NP_060755 NP_598737 Location (UCSC) Chr 15: 75.64 – 75.65 Mb Chr 9: 56.84 – 56.85 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

U3 small nucleolar ribonucleoprotein protein IMP3 is a protein that in humans is encoded by the IMP3 gene. ^{[5] [6] [7]}

Function

This gene encodes the human homolog of the yeast Imp3 protein. The protein localizes to the nucleoli and interacts with the U3 snoRNP complex. The protein contains an S4 domain. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000177971 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032288 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T (September 2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID   11543634.
6. Granneman S, Gallagher JE, Vogelzangs J, Horstman W, van Venrooij WJ, Baserga SJ, Pruijn GJ (April 2003). "The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes". Nucleic Acids Research. 31 (7): 1877–87. doi:10.1093/nar/gkg300. PMC   152815 . PMID   12655004.
7. "Entrez Gene: IMP3 IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast)".

Further reading

• Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (September 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID   7566098.
• Cross SH, Charlton JA, Nan X, Bird AP (March 1994). "Purification of CpG islands using a methylated DNA binding column". Nature Genetics. 6 (3): 236–44. doi:10.1038/ng0394-236. PMID   8012384. S2CID   12847618.
• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (January 2002). "Directed proteomic analysis of the human nucleolus". Current Biology. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi: 10.1016/S0960-9822(01)00650-9 . PMID   11790298.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (January 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID   15635413. S2CID   4344740.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Li C, Rock KL, Woda BA, Jiang Z, Fraire AE, Dresser K (February 2007). "IMP3 is a novel biomarker for adenocarcinoma in situ of the uterine cervix: an immunohistochemical study in comparison with p16(INK4a) expression". Modern Pathology. 20 (2): 242–7. doi: 10.1038/modpathol.3800735 . PMID   17192788.

Sources

• http://www.imp3.org/