INF2

INF2
Identifiers
Aliases	INF2 , C14orf151, C14orf173, CMTDIE, FSGS5, pp9484, inverted formin, FH2 and WH2 domain containing, inverted formin 2
External IDs	OMIM: 610982; MGI: 1917685; HomoloGene: 82406; GeneCards: INF2; OMA:INF2 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q32.33 Start 104,681,146 bp [1] End 104,722,535 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12|12 F1 Start 112,588,784 bp [2] End 112,615,557 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve C1 segment mucosa of transverse colon right coronary artery gastric mucosa left coronary artery popliteal artery tibial arteries putamen right frontal lobe Top expressed in gastrula superior frontal gyrus olfactory tubercle decidua nucleus accumbens stroma of bone marrow primary visual cortex epithelium of lens transitional epithelium of urinary bladder renal corpuscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding Cellular component cytoplasm perinuclear region of cytoplasm Biological process regulation of mitochondrial fission actin cytoskeleton organization cellular component organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64423 70435 Ensembl ENSG00000203485 ENSMUSG00000037679 UniProt Q27J81 Q0GNC1 RefSeq (mRNA) NM_001031714 NM_022489 NM_032714 NM_198411 RefSeq (protein) NP_001026884 NP_071934 NP_116103 NP_940803 NP_001361128 Location (UCSC) Chr 14: 104.68 – 104.72 Mb Chr 12: 112.59 – 112.62 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Inverted formin-2 is a protein that in humans is encoded by the INF2 gene. ^{[5] [6]} It belongs to the protein family called the formins. It has two splice isoforms, CAAX which localizes to the endoplasmic reticulum and non-CAAX which localizes to focal adhesions and the cytoplasm with enrichment at the Golgi. ^{[7] [8]} INF2 plays a role in mitochondrial fission and dorsal stress fiber formation. ^[9] INF2 accelerates actin nucleation and elongation by interacting with barbed ends (fast-growing ends) of actin filaments, but also accelerates disassembly of actin through encircling and severing filaments. ^[10]

Clinical significance

It can be associated with Focal segmental glomerulosclerosis ^[11] and Charcot-Marie-Tooth Disease. ^[12]

References

1. GRCh38: Ensembl release 89: ENSG00000203485 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037679 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chhabra ES, Higgs HN (September 2006). "INF2 Is a WASP homology 2 motif-containing formin that severs actin filaments and accelerates both polymerization and depolymerization". The Journal of Biological Chemistry. 281 (36): 26754–67. doi: 10.1074/jbc.M604666200 . PMID   16818491.
6. "Entrez Gene: C14orf173 chromosome 14 open reading frame 173".
7. Ramabhadran V, Korobova F, Rahme GJ, Higgs HN (December 2011). "Splice variant-specific cellular function of the formin INF2 in maintenance of Golgi architecture". Molecular Biology of the Cell. 22 (24): 4822–33. doi:10.1091/mbc.E11-05-0457. PMC   3237625 . PMID   21998196.
8. Chhabra ES, Ramabhadran V, Gerber SA, Higgs HN (May 2009). "INF2 is an endoplasmic reticulum-associated formin protein". Journal of Cell Science. 122 (Pt 9): 1430–40. doi:10.1242/jcs.040691. PMC   2721004 . PMID   19366733.
9. Korobova F, Ramabhadran V, Higgs HN (January 2013). "An actin-dependent step in mitochondrial fission mediated by the ER-associated formin INF2". Science. 339 (6118): 464–7. Bibcode:2013Sci...339..464K. doi:10.1126/science.1228360. PMC   3843506 . PMID   23349293.
10. Gurel PS, Ge P, Grintsevich EE, Shu R, Blanchoin L, Zhou ZH, Reisler E, Higgs HN (January 2014). "INF2-mediated severing through actin filament encirclement and disruption". Current Biology. 24 (2): 156–64. Bibcode:2014CBio...24..156G. doi:10.1016/j.cub.2013.12.018. PMC   3992431 . PMID   24412206.
11. Brown EJ, Schlöndorff JS, Becker DJ, Tsukaguchi H, Tonna SJ, Uscinski AL, Higgs HN, Henderson JM, Pollak MR (January 2010). "Mutations in the formin gene INF2 cause focal segmental glomerulosclerosis". Nature Genetics. 42 (1): 72–6. doi:10.1038/ng.505. PMC   2980844 . PMID   20023659.
12. Boyer O, Nevo F, Plaisier E, Funalot B, Gribouval O, Benoit G, Huynh Cong E, Arrondel C, Tête MJ, Montjean R, Richard L, Karras A, Pouteil-Noble C, Balafrej L, Bonnardeaux A, Canaud G, Charasse C, Dantal J, Deschenes G, Deteix P, Dubourg O, Petiot P, Pouthier D, Leguern E, Guiochon-Mantel A, Broutin I, Gubler MC, Saunier S, Ronco P, Vallat JM, Alonso MA, Antignac C, Mollet G (December 2011). "INF2 mutations in Charcot-Marie-Tooth disease with glomerulopathy". The New England Journal of Medicine. 365 (25): 2377–88. doi:10.1056/NEJMoa1109122. hdl: 10261/57029 . PMID   22187985. S2CID   17208136.

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Bindschadler M, McGrath JL (October 2004). "Formin' new ideas about actin filament generation". Proceedings of the National Academy of Sciences of the United States of America. 101 (41): 14685–6. Bibcode:2004PNAS..10114685B. doi: 10.1073/pnas.0406317101 . PMC   522045 . PMID   15466701.
• Fu GK, Wang JT, Yang J, Au-Young J, Stuve LL (July 2004). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes". Genomics. 84 (1): 205–10. doi:10.1016/j.ygeno.2004.01.011. PMID   15203218.
• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID   12665801. S2CID   23783563.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.