ING3

ING3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X4I
Identifiers
Aliases	ING3 , Eaf4, ING2, MEAF4, p47inhibitor of growth family member 3
External IDs	OMIM: 607493 MGI: 1919027 HomoloGene: 6804 GeneCards: ING3
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q31.31 Start 120,950,763 bp [1] End 120,977,216 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 A3.1 Start 21,949,570 bp [2] End 21,976,037 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte cancellous bone monocyte Achilles tendon bone marrow germinal epithelium parietal pleura visceral pleura optic nerve lower lobe of lung Top expressed in secondary oocyte spermatid medial ganglionic eminence abdominal wall cumulus cell thymus neural tube yolk sac blood left lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function histone acetyltransferase activity methylated histone binding metal ion binding Cellular component Piccolo NuA4 histone acetyltransferase complex nucleus nucleoplasm Swr1 complex NuA4 histone acetyltransferase complex Biological process histone H4 acetylation histone H2A acetylation regulation of growth regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of apoptotic process chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54556 71777 Ensembl ENSG00000071243 ENSMUSG00000029670 UniProt Q9NXR8 Q8VEK6 RefSeq (mRNA) NM_198267 NM_019071 NM_198266 NM_023626 NM_001311061 RefSeq (protein) NP_061944 NP_938008 NP_001297990 NP_076115 Location (UCSC) Chr 7: 120.95 – 120.98 Mb Chr 6: 21.95 – 21.98 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Inhibitor of growth protein 3 is a protein that in humans is encoded by the ING3 gene. ^{[5] [6]}

The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000071243 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029670 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gunduz M, Ouchida M, Fukushima K, Ito S, Jitsumori Y, Nakashima T, Nagai N, Nishizaki K, Shimizu K (Jun 2002). "Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers". Oncogene. 21 (28): 4462–70. doi: 10.1038/sj.onc.1205540 . PMID   12080476.
6. "Entrez Gene: ING3 inhibitor of growth family, member 3".

Further reading

• Doyon Y, Côté J (2004). "The highly conserved and multifunctional NuA4 HAT complex". Curr. Opin. Genet. Dev. 14 (2): 147–54. doi:10.1016/j.gde.2004.02.009. PMID   15196461.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi: 10.1101/gr.8.11.1097 . PMID   9847074.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Nagashima M, Shiseki M, Pedeux RM, et al. (2003). "A novel PHD-finger motif protein, p47ING3, modulates p53-mediated transcription, cell cycle control, and apoptosis". Oncogene. 22 (3): 343–50. doi: 10.1038/sj.onc.1206115 . PMID   12545155.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi: 10.1038/nature01782 . PMID   12853948.
• Cai Y, Jin J, Tomomori-Sato C, et al. (2003). "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex". J. Biol. Chem. 278 (44): 42733–6. doi: 10.1074/jbc.C300389200 . PMID   12963728.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Doyon Y, Selleck W, Lane WS, et al. (2004). "Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans". Mol. Cell. Biol. 24 (5): 1884–96. doi:10.1128/MCB.24.5.1884-1896.2004. PMC   350560 . PMID   14966270.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Cai Y, Jin J, Florens L, et al. (2005). "The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes". J. Biol. Chem. 280 (14): 13665–70. doi: 10.1074/jbc.M500001200 . PMID   15647280.
• Wang Y, Dai DL, Martinka M, Li G (2007). "Prognostic significance of nuclear ING3 expression in human cutaneous melanoma". Clin. Cancer Res. 13 (14): 4111–6. doi: 10.1158/1078-0432.CCR-07-0408 . PMID   17634537.