ITIH1

ITIH1
Identifiers
Aliases	ITIH1 , H1P, IATIH, IGHEP1, ITI-HC1, ITIH, SHAP, inter-alpha-trypsin inhibitor heavy chain 1
External IDs	OMIM: 147270 MGI: 96618 HomoloGene: 1667 GeneCards: ITIH1
Gene location (Human)
Chr.	Chromosome 3 (human)
End	52,792,068 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	30,665,246 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; right coronary artery; ; spleen; ; monocyte; ; left coronary artery; ; gallbladder; ; cecum; ; appendix; ; lymph node; ; subcutaneous adipose tissue;
	Top expressed in
	left lobe of liver; ; ankle joint; ; proximal tubule; ; sexually immature organism; ; gallbladder; ; yolk sac; ; thoracic diaphragm; ; right lobe of liver; ; placenta; ; kidney;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity ; calcium ion binding ; serine-type endopeptidase inhibitor activity ; protein binding ;
Cellular component	extracellular region ; blood microparticle ; extracellular exosome ; collagen-containing extracellular matrix ;
Biological process	negative regulation of peptidase activity ; negative regulation of endopeptidase activity ; hyaluronan metabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	3697
	16424
	ENSG00000055957
	ENSMUSG00000006529
	P19827
	Q61702
	NM_002215 ; NM_001166434 ; NM_001166435 ; NM_001166436
	NM_008406 ; NM_001306078
	NP_001159906 ; NP_001159907 ; NP_001159908 ; NP_002206
	NP_001293007 ; NP_032432
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Inter-alpha-trypsin inhibitor heavy chain H1 is a protein that in humans is encoded by the ITIH1 gene.^[5]^[6]^[7]

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Inter-alpha-trypsin inhibitor heavy chain H2 is a protein that in humans is encoded by the ITIH2 gene.

Inter-alpha-trypsin inhibitor heavy chain H3 is a protein that in humans is encoded by the ITIH3 gene.

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Inter-alpha-trypsin inhibitor heavy chain H4 is a protein that in humans is encoded by the ITIH4 gene.

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Matrix metalloproteinase 15 also known as MMP15 is an enzyme that in humans is encoded by the MMP15 gene.

Inter-alpha-trypsin inhibitors (IαI) are plasma proteins consisting of three of four heavy chains selected from the group ITIH1, ITIH2, ITIH3, ITIH4 and one light chain selected from the group AMBP or SPINT2. They function as protease inhibitors.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000055957 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006529 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Salier JP, Simon D, Rouet P, Raguenez G, Muscatelli F, Gebhard W, Guenet JL, Mattei MG (Dec 1992). "Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily". Genomics. 14 (1): 83–8. doi:10.1016/S0888-7543(05)80287-3. PMID 1385302.
↑ Jean L, Risler JL, Nagase T, Coulouarn C, Nomura N, Salier JP (May 1999). "The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair?". FEBS Lett. 446 (1): 6–8. doi: 10.1016/S0014-5793(99)00173-8 . PMID 10100603. S2CID 84807160.
↑ "Entrez Gene: ITIH1 inter-alpha (globulin) inhibitor H1".

Diarra-Mehrpour M, Bourguignon J, Bost F, et al. (1992). "Human inter-alpha-trypsin inhibitor: full-length cDNA sequence of the heavy chain H1". Biochim. Biophys. Acta. 1132 (1): 114–8. doi:10.1016/0167-4781(92)90065-8. PMID 1380832.
Malki N, Balduyck M, Maes P, et al. (1992). "The heavy chains of human plasma inter-alpha-trypsin inhibitor: their isolation, their identification by electrophoresis and partial sequencing. Differential reactivity with concanavalin A". Biol. Chem. Hoppe-Seyler. 373 (10): 1009–18. doi:10.1515/bchm3.1992.373.2.1009. PMID 1384548.
Salier JP, Diarra-Mehrpour M, Sesboue R, et al. (1988). "Isolation and characterization of cDNAs encoding the heavy chain of human inter-alpha-trypsin inhibitor (I alpha TI): unambiguous evidence for multipolypeptide chain structure of I alpha TI". Proc. Natl. Acad. Sci. U.S.A. 84 (23): 8272–6. doi: 10.1073/pnas.84.23.8272 . PMC 299524 . PMID 2446322.
Diarra-Mehrpour M, Bourguignon J, Sesboüé R, et al. (1989). "Human plasma inter-alpha-trypsin inhibitor is encoded by four genes on three chromosomes". Eur. J. Biochem. 179 (1): 147–54. doi: 10.1111/j.1432-1033.1989.tb14532.x . PMID 2465147.
Gebhard W, Schreitmüller T, Hochstrasser K, Wachter E (1989). "Two out of the three kinds of subunits of inter-alpha-trypsin inhibitor are structurally related". Eur. J. Biochem. 181 (3): 571–6. doi: 10.1111/j.1432-1033.1989.tb14762.x . PMID 2471637.
Enghild JJ, Thøgersen IB, Pizzo SV, Salvesen G (1989). "Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan". J. Biol. Chem. 264 (27): 15975–81. doi: 10.1016/S0021-9258(18)71575-5 . PMID 2476436.
Schreitmüller T, Hochstrasser K, Reisinger PW, et al. (1987). "cDNA cloning of human inter-alpha-trypsin inhibitor discloses three different proteins". Biol. Chem. Hoppe-Seyler. 368 (8): 963–70. doi:10.1515/bchm3.1987.368.2.963. PMID 3663330.
Huang L, Yoneda M, Kimata K (1994). "A serum-derived hyaluronan-associated protein (SHAP) is the heavy chain of the inter alpha-trypsin inhibitor". J. Biol. Chem. 268 (35): 26725–30. doi: 10.1016/S0021-9258(19)74373-7 . PMID 7504674.
Bost F, Bourguignon J, Martin JP, et al. (1994). "Isolation and characterization of the human inter-alpha-trypsin inhibitor heavy-chain H1 gene". Eur. J. Biochem. 218 (2): 283–91. doi: 10.1111/j.1432-1033.1993.tb18376.x . PMID 7505744.
Morelle W, Capon C, Balduyck M, et al. (1994). "Chondroitin sulphate covalently cross-links the three polypeptide chains of inter-alpha-trypsin inhibitor". Eur. J. Biochem. 221 (2): 881–8. doi:10.1111/j.1432-1033.1994.tb18803.x. PMID 7513643.
Diarra-Mehrpour M, Bourguignon J, Sarafan N, et al. (1994). "Tandem orientation of the inter-alpha-trypsin inhibitor heavy chain H1 and H3 genes". Biochim. Biophys. Acta. 1219 (2): 551–4. doi:10.1016/0167-4781(94)90087-6. PMID 7522574.
Ding M, Umetsu K, Yuasa I, et al. (1995). "Molecular basis of inter-alpha-trypsin inhibitor heavy chain H1 (ITIH1) polymorphism". Hum. Genet. 95 (4): 435–6. doi:10.1007/BF00208970. PMID 7535743. S2CID 26535335.
Zhao M, Yoneda M, Ohashi Y, et al. (1995). "Evidence for the covalent binding of SHAP, heavy chains of inter-alpha-trypsin inhibitor, to hyaluronan". J. Biol. Chem. 270 (44): 26657–63. doi: 10.1074/jbc.270.44.26657 . PMID 7592891.
Bourguignon J, Diarra-Mehrpour M, Thiberville L, et al. (1993). "Human pre-alpha-trypsin inhibitor-precursor heavy chain. cDNA and deduced amino-acid sequence". Eur. J. Biochem. 212 (3): 771–6. doi: 10.1111/j.1432-1033.1993.tb17717.x . PMID 7681778.
Olsen EH, Rahbek-Nielsen H, Thogersen IB, et al. (1998). "Posttranslational modifications of human inter-alpha-inhibitor: identification of glycans and disulfide bridges in heavy chains 1 and 2". Biochemistry. 37 (1): 408–16. doi:10.1021/bi971137d. PMID 9425062.
Flahaut C, Capon C, Balduyck M, et al. (1998). "Glycosylation pattern of human inter-alpha-inhibitor heavy chains". Biochem. J. 333 ( Pt 3) (Pt 3): 749–56. doi:10.1042/bj3330749. PMC 1219641 . PMID 9677337.
Flahaut C, Mizon C, Aumercier-Maes P, et al. (1998). "Disulphide bonds assignment in the inter-alpha-inhibitor heavy chains--structural and functional implications". Eur. J. Biochem. 255 (1): 107–15. doi: 10.1046/j.1432-1327.1998.2550107.x . PMID 9692908.
Diarra-Mehrpour M, Sarafan N, Bourguignon J, et al. (1998). "Human inter-alpha-trypsin inhibitor heavy chain H3 gene. Genomic organization, promoter analysis, and gene linkage". J. Biol. Chem. 273 (41): 26809–19. doi: 10.1074/jbc.273.41.26809 . PMID 9756925.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000055957 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006529 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1385302-5] Salier JP, Simon D, Rouet P, Raguenez G, Muscatelli F, Gebhard W, Guenet JL, Mattei MG (Dec 1992). "Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily". Genomics. 14 (1): 83–8. doi:10.1016/S0888-7543(05)80287-3. PMID 1385302.

[pmid10100603-6] Jean L, Risler JL, Nagase T, Coulouarn C, Nomura N, Salier JP (May 1999). "The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair?". FEBS Lett. 446 (1): 6–8. doi: 10.1016/S0014-5793(99)00173-8 . PMID 10100603. S2CID 84807160.

[entrez-7] "Entrez Gene: ITIH1 inter-alpha (globulin) inhibitor H1".

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ITIH1

Contents

See also

Related Research Articles

References

Further reading