ITIH4

ITIH4
Identifiers
Aliases	ITIH4 , GP120, H4P, IHRP, ITI-HC4, ITIHL1, PK-120, PK120, inter-alpha-trypsin inhibitor heavy chain family member 4, inter-alpha-trypsin inhibitor heavy chain 4
External IDs	OMIM: 600564 MGI: 109536 HomoloGene: 1670 GeneCards: ITIH4
Gene location (Human)
Chr.	Chromosome 3 (human)
End	52,830,688 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	30,624,310 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; right coronary artery; ; popliteal artery; ; left coronary artery; ; body of pancreas; ; sperm; ; gastrocnemius muscle; ; ascending aorta; ; sural nerve; ; gastric mucosa;
	Top expressed in
	left lobe of liver; ; ascending aorta; ; aortic valve; ; gallbladder; ; right lung lobe; ; carotid body; ; sexually immature organism; ; left lung; ; pyloric antrum; ; islet of Langerhans;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase inhibitor activity ; endopeptidase inhibitor activity ; protein binding ; serine-type endopeptidase inhibitor activity ;
Cellular component	cytoplasm ; plasma membrane ; blood microparticle ; extracellular exosome ; platelet dense granule lumen ; extracellular region ; collagen-containing extracellular matrix ;
Biological process	response to cytokine ; negative regulation of peptidase activity ; acute-phase response ; hyaluronan metabolic process ; platelet degranulation ; negative regulation of endopeptidase activity ;
	Sources:Amigo / QuickGO
Orthologs
	3700
	16427
	ENSG00000055955
	ENSMUSG00000021922
	Q14624
	A6X935
	NM_002218 ; NM_001166449
	NM_001159299 ; NM_001289632 ; NM_001289633 ; NM_018746
	NP_001159921 ; NP_002209
	NP_001152771 ; NP_001276561 ; NP_001276562 ; NP_061216
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated May 13, 2024

Inter-alpha-trypsin inhibitor heavy chain H4 is a protein that in humans is encoded by the ITIH4 gene.^[5]^[6]^[7]

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Inter-alpha-trypsin inhibitors (IαI) are plasma proteins consisting of three of four heavy chains selected from the group ITIH1, ITIH2, ITIH3, ITIH4 and one light chain selected from the group AMBP or SPINT2. They function as protease inhibitors.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000055955 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021922 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Soury E, Olivier E, Daveau M, Hiron M, Claeyssens S, Risler JL, Salier JP (Mar 1998). "The H4P heavy chain of inter-alpha-inhibitor family largely differs in the structure and synthesis of its prolin-rich region from rat to human". Biochem Biophys Res Commun. 243 (2): 522–30. doi:10.1006/bbrc.1998.8128. PMID 9480842.
↑ Nishimura H, Kakizaki I, Muta T, Sasaki N, Pu PX, Yamashita T, Nagasawa S (Feb 1995). "cDNA and deduced amino acid sequence of human PK-120, a plasma kallikrein-sensitive glycoprotein". FEBS Lett. 357 (2): 207–11. Bibcode:1995FEBSL.357..207H. doi: 10.1016/0014-5793(94)01364-7 . PMID 7805892.
↑ "Entrez Gene: ITIH4 inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)".

Choi-Miura NH, Sano Y, Oda E, et al. (1995). "Purification and characterization of a novel glycoprotein which has significant homology to heavy chains of inter-alpha-trypsin inhibitor family from human plasma". J. Biochem. 117 (2): 400–7. doi:10.1093/jb/117.2.400. PMID 7541790.
Tobe T, Saguchi K, Hashimoto K, et al. (1995). "Mapping of human inter-alpha-trypsin inhibitor family heavy chain-related protein gene (ITIHL1) to human chromosome 3p21→p14". Cytogenet. Cell Genet. 71 (3): 296–8. doi:10.1159/000134130. PMID 7587397.
Saguchi K, Tobe T, Hashimoto K, et al. (1995). "Cloning and characterization of cDNA for inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP), a novel human plasma glycoprotein". J. Biochem. 117 (1): 14–8. doi:10.1093/oxfordjournals.jbchem.a124701. PMID 7775381.
Saguchi K, Tobe T, Hashimoto K, et al. (1997). "Isolation and characterization of the human inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP) gene (ITIHL1)". J. Biochem. 119 (5): 898–905. doi:10.1093/oxfordjournals.jbchem.a021327. PMID 8797089.
Jean L, Smih F, Olivier E, et al. (1997). "Comparative assignments of the genes of the inter-alpha-inhibitor family in human and mouse: ITIH4 is close to ITIH1 and ITIH3, on HSA 3 and MMU 14". Genomics. 41 (1): 139–40. doi:10.1006/geno.1997.4612. PMID 9126497.
Diarra-Mehrpour M, Sarafan N, Bourguignon J, et al. (1998). "Human inter-alpha-trypsin inhibitor heavy chain H3 gene. Genomic organization, promoter analysis, and gene linkage". J. Biol. Chem. 273 (41): 26809–19. doi: 10.1074/jbc.273.41.26809 . PMID 9756925.
Tozaki T, Choi-Miura NH, Taniyama M, et al. (2003). "SNP analysis of the inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP) gene by a fluorescence-adapted SSCP method". BMC Med. Genet. 3: 6. doi: 10.1186/1471-2350-3-6 . PMC 117798 . PMID 12147176.
Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nat. Biotechnol. 21 (6): 660–6. doi:10.1038/nbt827. PMID 12754519. S2CID 581283.
Fujita Y, Ezura Y, Emi M, et al. (2004). "Hypercholesterolemia associated with splice-junction variation of inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) gene". J. Hum. Genet. 49 (1): 24–8. doi: 10.1007/s10038-003-0101-8 . PMID 14661079.
Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Mol. Cell. Proteomics. 3 (4): 311–26. doi: 10.1074/mcp.M300127-MCP200 . PMID 14718574.
Bunkenborg J, Pilch BJ, Podtelejnikov AV, Wiśniewski JR (2004). "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry". Proteomics. 4 (2): 454–65. doi:10.1002/pmic.200300556. PMID 14760718. S2CID 29261009.
Kroczynska B, King-Simmons L, Alloza L, et al. (2006). "BIP co-chaperone MTJ1/ERDJ1 interacts with inter-alpha-trypsin inhibitor heavy chain 4". Biochem. Biophys. Res. Commun. 338 (3): 1467–77. doi:10.1016/j.bbrc.2005.10.101. PMID 16271702.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943 . PMID 16335952.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000055955 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021922 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9480842-5] Soury E, Olivier E, Daveau M, Hiron M, Claeyssens S, Risler JL, Salier JP (Mar 1998). "The H4P heavy chain of inter-alpha-inhibitor family largely differs in the structure and synthesis of its prolin-rich region from rat to human". Biochem Biophys Res Commun. 243 (2): 522–30. doi:10.1006/bbrc.1998.8128. PMID 9480842.

[pmid7805892-6] Nishimura H, Kakizaki I, Muta T, Sasaki N, Pu PX, Yamashita T, Nagasawa S (Feb 1995). "cDNA and deduced amino acid sequence of human PK-120, a plasma kallikrein-sensitive glycoprotein". FEBS Lett. 357 (2): 207–11. Bibcode:1995FEBSL.357..207H. doi: 10.1016/0014-5793(94)01364-7 . PMID 7805892.

[entrez-7] "Entrez Gene: ITIH4 inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)".

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ITIH4

Contents

See also

Related Research Articles

References

Further reading