ITIH3

ITIH3
Identifiers
Aliases	ITIH3 , H3P, ITI-HC3, SHAP, inter-alpha-trypsin inhibitor heavy chain 3
External IDs	OMIM: 146650 MGI: 96620 HomoloGene: 1669 GeneCards: ITIH3
Gene location (Human)
Chr.	Chromosome 3 (human)
End	52,809,009 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	30,645,717 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; right coronary artery; ; popliteal artery; ; left coronary artery; ; saphenous vein; ; tibial nerve; ; sural nerve; ; spleen; ; sperm; ; right lung;
	Top expressed in
	ventromedial nucleus; ; left lobe of liver; ; dorsomedial hypothalamic nucleus; ; paraventricular nucleus of hypothalamus; ; lateral hypothalamus; ; arcuate nucleus; ; dorsal tegmental nucleus; ; mammillary body; ; ventral tegmental area; ; medial vestibular nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity ; endopeptidase inhibitor activity ; serine-type endopeptidase inhibitor activity ; protein binding ;
Cellular component	extracellular exosome ; platelet dense granule lumen ; extracellular region ;
Biological process	negative regulation of peptidase activity ; hyaluronan metabolic process ; negative regulation of endopeptidase activity ; platelet degranulation ;
	Sources:Amigo / QuickGO
Orthologs
	3699
	16426
	ENSG00000162267
	ENSMUSG00000006522
	Q06033
	Q61704
	NM_002217
	NM_008407
	NP_002208
	NP_032433
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 19, 2023

Inter-alpha-trypsin inhibitor heavy chain H3 is a protein that in humans is encoded by the ITIH3 gene.^[5]^[6]^[7]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000162267 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006522 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Diarra-Mehrpour M, Bourguignon J, Sesboue R, Mattei MG, Passage E, Salier JP, Martin JP (Apr 1989). "Human plasma inter-alpha-trypsin inhibitor is encoded by four genes on three chromosomes". Eur J Biochem. 179 (1): 147–54. doi:10.1111/j.1432-1033.1989.tb14532.x. PMID 2465147.
↑ Jean L, Risler JL, Nagase T, Coulouarn C, Nomura N, Salier JP (May 1999). "The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair?". FEBS Lett. 446 (1): 6–8. doi:10.1016/S0014-5793(99)00173-8. PMID 10100603. S2CID 84807160.
↑ "Entrez Gene: ITIH3 inter-alpha (globulin) inhibitor H3".

Salier JP, Simon D, Rouet P, et al. (1992). "Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily". Genomics. 14 (1): 83–8. doi:10.1016/S0888-7543(05)80287-3. PMID 1385302.
Enghild JJ, Salvesen G, Hefta SA, et al. (1991). "Chondroitin 4-sulfate covalently cross-links the chains of the human blood protein pre-alpha-inhibitor". J. Biol. Chem. 266 (2): 747–51. doi: 10.1016/S0021-9258(17)35235-3 . PMID 1898736.
Salier JP, Diarra-Mehrpour M, Sesboue R, et al. (1988). "Isolation and characterization of cDNAs encoding the heavy chain of human inter-alpha-trypsin inhibitor (I alpha TI): unambiguous evidence for multipolypeptide chain structure of I alpha TI". Proc. Natl. Acad. Sci. U.S.A. 84 (23): 8272–6. doi: 10.1073/pnas.84.23.8272 . PMC 299524 . PMID 2446322.
Enghild JJ, Thøgersen IB, Pizzo SV, Salvesen G (1989). "Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan". J. Biol. Chem. 264 (27): 15975–81. doi: 10.1016/S0021-9258(18)71575-5 . PMID 2476436.
Diarra-Mehrpour M, Bourguignon J, Sarafan N, et al. (1994). "Tandem orientation of the inter-alpha-trypsin inhibitor heavy chain H1 and H3 genes". Biochim. Biophys. Acta. 1219 (2): 551–4. doi:10.1016/0167-4781(94)90087-6. PMID 7522574.
Bourguignon J, Diarra-Mehrpour M, Thiberville L, et al. (1993). "Human pre-alpha-trypsin inhibitor-precursor heavy chain. cDNA and deduced amino-acid sequence". Eur. J. Biochem. 212 (3): 771–6. doi:10.1111/j.1432-1033.1993.tb17717.x. PMID 7681778.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Blom AM, Thuveson M, Fries E (1998). "Intracellular coupling of bikunin and the heavy chain of rat pre-alpha-inhibitor in COS-1 cells". Biochem. J. 328 (1): 185–91. doi:10.1042/bj3280185. PMC 1218904 . PMID 9359851.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Diarra-Mehrpour M, Sarafan N, Bourguignon J, et al. (1998). "Human inter-alpha-trypsin inhibitor heavy chain H3 gene. Genomic organization, promoter analysis, and gene linkage". J. Biol. Chem. 273 (41): 26809–19. doi: 10.1074/jbc.273.41.26809 . PMID 9756925.
Thuveson M, Fries E (1999). "Intracellular proteolytic processing of the heavy chain of rat pre-alpha-inhibitor. The COOH-terminal propeptide is required for coupling to bikunin". J. Biol. Chem. 274 (10): 6741–6. doi: 10.1074/jbc.274.10.6741 . PMID 10037773.
Bourguignon J, Borghi H, Sesboüé R, et al. (1999). "Immunohistochemical distribution of inter-alpha-trypsin inhibitor chains in normal and malignant human lung tissue". J. Histochem. Cytochem. 47 (12): 1625–32. doi: 10.1177/002215549904701214 . PMID 10567446.
Thuveson M, Fries E (2000). "The low pH in trans-Golgi triggers autocatalytic cleavage of pre-alpha -inhibitor heavy chain precursor". J. Biol. Chem. 275 (40): 30996–1000. doi: 10.1074/jbc.M002399200 . PMID 10893227.
Kato M, Seki N, Sugano S, et al. (2002). "Identification of sonic hedgehog-responsive genes using cDNA microarray". Biochem. Biophys. Res. Commun. 289 (2): 472–8. doi:10.1006/bbrc.2001.5976. PMID 11716497.
Paris S, Sesboüé R, Delpech B, et al. (2002). "Inhibition of tumor growth and metastatic spreading by overexpression of inter-alpha-trypsin inhibitor family chains". Int. J. Cancer. 97 (5): 615–20. doi:10.1002/ijc.10120. PMID 11807786. S2CID 41750371.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000162267 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006522 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2465147-5] Diarra-Mehrpour M, Bourguignon J, Sesboue R, Mattei MG, Passage E, Salier JP, Martin JP (Apr 1989). "Human plasma inter-alpha-trypsin inhibitor is encoded by four genes on three chromosomes". Eur J Biochem. 179 (1): 147–54. doi:10.1111/j.1432-1033.1989.tb14532.x. PMID 2465147.

[pmid10100603-6] Jean L, Risler JL, Nagase T, Coulouarn C, Nomura N, Salier JP (May 1999). "The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair?". FEBS Lett. 446 (1): 6–8. doi:10.1016/S0014-5793(99)00173-8. PMID 10100603. S2CID 84807160.

[entrez-7] "Entrez Gene: ITIH3 inter-alpha (globulin) inhibitor H3".

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ITIH3

Contents

See also

Related Research Articles

References

Further reading