Integrin alpha 10

ITGA10
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1PT6, 1QC5, 1QCY, 2L8S, 2M32, 4A0Q
Identifiers
Aliases	ITGA10 , PRO827, integrin subunit alpha 10
External IDs	OMIM: 604042 MGI: 2153482 HomoloGene: 2697 GeneCards: ITGA10
Gene location (Human)
Chr.	Chromosome 1 (human)
End	145,910,111 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	96,571,835 bp
RNA expression pattern
	Top expressed in
	tibia; ; ascending aorta; ; right coronary artery; ; Achilles tendon; ; gastric mucosa; ; periodontal fiber; ; left coronary artery; ; right lung; ; upper lobe of left lung; ; tibial nerve;
	Top expressed in
	calvaria; ; dermal bone; ; human mandible; ; sphenoid bone; ; fossa; ; maxilla; ; basisphenoid; ; body of femur; ; axial skeleton; ; stria vascularis;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding ; collagen binding involved in cell-matrix adhesion ; collagen binding ;
Cellular component	integrin complex ; plasma membrane ; membrane ; integrin alpha10-beta1 complex ; integral component of membrane ;
Biological process	cell-matrix adhesion ; extracellular matrix organization ; cell adhesion ; integrin-mediated signaling pathway ;
	Sources:Amigo / QuickGO
Orthologs
	8515
	213119
	ENSG00000143127
	ENSMUSG00000090210
	O75578
	n/a
	NM_001303040 ; NM_001303041 ; NM_003637
	NM_001081053 ; NM_001302471
	NP_001289969 ; NP_001289970 ; NP_003628
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 08, 2023

Integrin alpha-10 also known as ITGA10 is a protein that in humans is encoded by the ITGA10 gene.^[5]^[6]^[7]

Function

Integrins are integral membrane proteins composed of an alpha chain and a beta chain, and are known to participate in cell adhesion as well as cell-surface mediated signalling. The I-domain containing alpha 10 combines with the integrin beta 1 chain (ITGB1) to form a novel collagen type II-binding integrin expressed in cartilage tissue.^[5]

Related Research Articles

Integrin beta-1 (ITGB1), also known as CD29, is a cell surface receptor that in humans is encoded by the ITGB1 gene. This integrin associates with integrin alpha 1 and integrin alpha 2 to form integrin complexes which function as collagen receptors. It also forms dimers with integrin alpha 3 to form integrin receptors for netrin 1 and reelin. These and other integrin beta 1 complexes have been historically known as very late activation (VLA) antigens.

Integrin alpha-1 also CD49a is an integrin alpha subunit encoded in humans by the gene ITGA1. It makes up half of the α1β1 integrin duplex. Though CD49a can bind a number of ligands including collagen IV, collagen I, and others.

Integrin alpha-2, or CD49b, is a protein which in humans is encoded by the CD49b gene.

Collagen alpha-1(V) chain is a protein that in humans is encoded by the COL5A1 gene.

Collagen alpha-2(V) chain is a protein that in humans is encoded by the COL5A2 gene.

Gap junction alpha-5 protein (GJA5), also known as connexin 40 (Cx40) — is a protein that in humans is encoded by the GJA5 gene.

Disintegrin and metalloproteinase domain-containing protein 15 is an enzyme that in humans is encoded by the ADAM15 gene.

Collagen alpha-5(IV) chain is a protein that in humans is encoded by the COL4A5 gene.

Collagen alpha-1(XVIII) chain is a protein that in humans is encoded by the COL18A1 gene.

Laminin subunit alpha-3 is a protein that in humans is encoded by the LAMA3 gene.

Laminin subunit alpha-2 is a protein that in humans is encoded by the LAMA2 gene.

Fragile X mental retardation syndrome-related protein 1 is a protein that in humans is encoded by the FXR1 gene.

Filamin B, beta (FLNB), also known as Filamin B, beta , is a cytoplasmic protein which in humans is encoded by the FLNB gene.

Collagen alpha-1(XI) chain is a protein that in humans is encoded by the COL11A1 gene.

Integrin beta-1-binding protein 1 is a protein that in humans is encoded by the ITGB1BP1 gene.

5'-AMP-activated protein kinase subunit beta-2 is an enzyme that in humans is encoded by the PRKAB2 gene.

Collagen alpha-2(VIII) chain is a protein that in humans is encoded by the COL8A2 gene. Mutations of the gene are linked to posterior polymorphous dystrophy type 2.

Integrin beta-8 is a protein that in humans is encoded by the ITGB8 gene.

Integrin alpha-8 is a protein that in humans is encoded by the ITGA8 gene.

Integrin alpha-11 is a protein that, in humans, is encoded by the ITGA11 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000143127 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000090210 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: ITGA10 integrin, alpha 10".
↑ Camper L, Hellman U, Lundgren-Akerlund E (August 1998). "Isolation, cloning, and sequence analysis of the integrin subunit alpha10, a beta1-associated collagen binding integrin expressed on chondrocytes". J. Biol. Chem. 273 (32): 20383–9. doi: 10.1074/jbc.273.32.20383 . PMID 9685391.
↑ Lehnert K, Ni J, Leung E, Gough S, Morris CM, Liu D, Wang SX, Langley R, Krissansen GW (1999). "The integrin alpha10 subunit: expression pattern, partial gene structure, and chromosomal localization". Cytogenet. Cell Genet. 87 (3–4): 238–44. doi:10.1159/000015434. PMID 10702680. S2CID 85257405.
↑ Klopocki E, Schulze H, Strauss G, et al. (February 2007). "Complex Inheritance Pattern Resembling Autosomal Recessive Inheritance Involving a Microdeletion in Thrombocytopenia–Absent Radius Syndrome". Am. J. Hum. Genet. 80 (2): 232–40. doi:10.1086/510919. PMC 1785342 . PMID 17236129.

External links

ITGA10 Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000143127 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000090210 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: ITGA10 integrin, alpha 10".

[pmid9685391-6] Camper L, Hellman U, Lundgren-Akerlund E (August 1998). "Isolation, cloning, and sequence analysis of the integrin subunit alpha10, a beta1-associated collagen binding integrin expressed on chondrocytes". J. Biol. Chem. 273 (32): 20383–9. doi: 10.1074/jbc.273.32.20383 . PMID 9685391.

[pmid10702680-7] Lehnert K, Ni J, Leung E, Gough S, Morris CM, Liu D, Wang SX, Langley R, Krissansen GW (1999). "The integrin alpha10 subunit: expression pattern, partial gene structure, and chromosomal localization". Cytogenet. Cell Genet. 87 (3–4): 238–44. doi:10.1159/000015434. PMID 10702680. S2CID 85257405.

[pmid17236129-8] Klopocki E, Schulze H, Strauss G, et al. (February 2007). "Complex Inheritance Pattern Resembling Autosomal Recessive Inheritance Involving a Microdeletion in Thrombocytopenia–Absent Radius Syndrome". Am. J. Hum. Genet. 80 (2): 232–40. doi:10.1086/510919. PMC 1785342 . PMID 17236129.

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Integrin alpha 10

Contents

Function

Related gene problems

Related Research Articles

References

Further reading

External links