Integrin beta 5

ITGB5
Identifiers
Aliases	ITGB5 , Integrin, beta 5, integrin subunit beta 5
External IDs	OMIM: 147561; MGI: 96614; HomoloGene: 20511; GeneCards: ITGB5; OMA:ITGB5 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q21.2 Start 124,761,948 bp [1] End 124,901,418 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16|16 B3 Start 33,650,035 bp [2] End 33,769,708 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium right coronary artery ascending aorta Descending thoracic aorta pancreatic ductal cell tendon of biceps brachii cartilage tissue left coronary artery metanephric glomerulus popliteal artery Top expressed in tunica media of zone of aorta epithelium of lens decidua calvaria ciliary body molar external carotid artery gastrula stria vascularis stroma of bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function virus receptor activity protein binding integrin binding signaling receptor activity Cellular component integral component of membrane membrane focal adhesion receptor complex plasma membrane cell surface integrin complex phagocytic vesicle integrin alphav-beta5 complex extracellular exosome Biological process muscle contraction endodermal cell differentiation antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent extracellular matrix organization epithelial cell-cell adhesion stress fiber assembly cell adhesion integrin-mediated signaling pathway viral entry into host cell cell-matrix adhesion viral process transforming growth factor beta receptor signaling pathway cell migration cell adhesion mediated by integrin Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3693 16419 Ensembl ENSG00000082781 ENSMUSG00000022817 UniProt P18084 O70309 RefSeq (mRNA) NM_002213 NM_001354764 NM_001354765 NM_001354766 NM_001145884 NM_010580 RefSeq (protein) NP_002204 NP_001341693 NP_001341694 NP_001341695 NP_001139356 NP_034710 NP_001391992 Location (UCSC) Chr 3: 124.76 – 124.9 Mb Chr 16: 33.65 – 33.77 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Integrin beta-5 is a protein that in humans is encoded by the ITGB5 gene. ^{[5] [6]}

Interactions

Integrin, beta 5 has been shown to interact with PTK2, ^[7] Annexin A5 ^[8] and PAK4. ^[9]

Functions

ITGB5 encodes a subunit of integrin that can interact with several alpha chains to form a variety of integrin heterodimers. It also plays a potential role in intercellular communication during tumor progression and metastasis. ^[10]

Clinical significance

Research

Elevated levels of ITGB5 have been found in patients with autosomal dominant osteopetrosis type II, a rare disease of bones. ^[11]

References

1. GRCh38: Ensembl release 89: ENSG00000082781 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022817 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. McLean JW, Vestal DJ, Cheresh DA, Bodary SC (Nov 1990). "cDNA sequence of the human integrin beta 5 subunit". J Biol Chem. 265 (28): 17126–31. doi: 10.1016/S0021-9258(17)44878-2 . PMID   2211615.
6. "Entrez Gene: ITGB5 integrin, beta 5".
7. Eliceiri BP, Puente Xose S, Hood John D, Stupack Dwayne G, Schlaepfer David D, Huang Xiaozhu Z, Sheppard Dean, Cheresh David A (Apr 2002). "Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling". J. Cell Biol. 157 (1): 149–60. doi:10.1083/jcb.200109079. ISSN   0021-9525. PMC   2173263 . PMID   11927607.
8. Cardó-Vila M, Arap Wadih, Pasqualini Renata (May 2003). "Alpha v beta 5 integrin-dependent programmed cell death triggered by a peptide mimic of annexin V". Mol. Cell. 11 (5): 1151–62. doi: 10.1016/S1097-2765(03)00138-2 . ISSN   1097-2765. PMID   12769841.
9. Zhang H, Li Zhilun, Viklund Eva-Karin, Strömblad Staffan (Sep 2002). "P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration". J. Cell Biol. 158 (7): 1287–97. doi:10.1083/jcb.200207008. ISSN   0021-9525. PMC   2173231 . PMID   12356872.
10. Zhang Ly, Guo Q, Guan Gf, Cheng W, Cheng P, Wu Ah (2019). "Integrin Beta 5 Is a Prognostic Biomarker and Potential Therapeutic Target in Glioblastoma". Frontiers in Oncology. 9: 904. doi: 10.3389/fonc.2019.00904 . ISSN   2234-943X. PMC   6764112 . PMID   31616629.
11. Coudert, AE (Mar 2014). "Differentially expressed genes in autosomal dominant osteopetrosis type II osteoclasts reveal known and novel pathways for osteoclast biology" (PDF). Lab. Invest. 94 (3): 275–285. doi: 10.1038/labinvest.2013.140 . PMID   24336069. S2CID   5097233.

Further reading

• Evans JP (2001). "Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization". BioEssays. 23 (7): 628–39. doi:10.1002/bies.1088. PMID   11462216. S2CID   23712246.
• Smith JW, Vestal DJ, Irwin SV, et al. (1990). "Purification and functional characterization of integrin alpha v beta 5. An adhesion receptor for vitronectin". J. Biol. Chem. 265 (19): 11008–13. doi: 10.1016/S0021-9258(19)38549-7 . PMID   1694173.
• Adams JC, Watt FM (1991). "Expression of beta 1, beta 3, beta 4, and beta 5 integrins by human epidermal keratinocytes and non-differentiating keratinocytes". J. Cell Biol. 115 (3): 829–41. doi:10.1083/jcb.115.3.829. PMC   2289188 . PMID   1918165.
• Ramaswamy H, Hemler ME (1990). "Cloning, primary structure and properties of a novel human integrin beta subunit". EMBO J. 9 (5): 1561–8. doi:10.1002/j.1460-2075.1990.tb08275.x. PMC   551850 . PMID   2328726.
• Suzuki S, Huang ZS, Tanihara H (1990). "Cloning of an integrin beta subunit exhibiting high homology with integrin beta 3 subunit". Proc. Natl. Acad. Sci. U.S.A. 87 (14): 5354–8. Bibcode:1990PNAS...87.5354S. doi: 10.1073/pnas.87.14.5354 . PMC   54322 . PMID   2371275.
• Hu DD, Lin EC, Kovach NL, et al. (1995). "A biochemical characterization of the binding of osteopontin to integrins alpha v beta 1 and alpha v beta 5". J. Biol. Chem. 270 (44): 26232–8. doi: 10.1074/jbc.270.44.26232 . PMID   7592829.
• Vogel BE, Lee SJ, Hildebrand A, et al. (1993). "A novel integrin specificity exemplified by binding of the alpha v beta 5 integrin to the basic domain of the HIV Tat protein and vitronectin". J. Cell Biol. 121 (2): 461–8. doi:10.1083/jcb.121.2.461. PMC   2200091 . PMID   7682219.
• Pasqualini R, Bodorova J, Ye S, Hemler ME (1993). "A study of the structure, function and distribution of beta 5 integrins using novel anti-beta 5 monoclonal antibodies". J. Cell Sci. 105 (1): 101–11. doi:10.1242/jcs.105.1.101. PMID   7689573.
• Lafrenie RM, Wahl LM, Epstein JS, et al. (1996). "HIV-1-Tat protein promotes chemotaxis and invasive behavior by monocytes". Journal of Immunology. 157 (3): 974–7. doi: 10.4049/jimmunol.157.3.974 . PMID   8757599.
• Rabb H, Barroso-Vicens E, Adams R, et al. (1997). "Alpha-V/beta-3 and alpha-V/beta-5 integrin distribution in neoplastic kidney". Am. J. Nephrol. 16 (5): 402–8. doi:10.1159/000169032. PMID   8886177.
• Liliental J, Chang DD (1998). "Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit". J. Biol. Chem. 273 (4): 2379–83. doi: 10.1074/jbc.273.4.2379 . PMID   9442085.
• Memmo LM, McKeown-Longo P (1998). "The alphavbeta5 integrin functions as an endocytic receptor for vitronectin". J. Cell Sci. 111 (4): 425–33. doi:10.1242/jcs.111.4.425. PMID   9443892.
• Zhang H, Tan SM, Lu J (1998). "cDNA cloning reveals two mouse beta5 integrin transcripts distinct in cytoplasmic domains as a result of alternative splicing". Biochem. J. 331 (2): 631–7. doi:10.1042/bj3310631. PMC   1219398 . PMID   9531507.
• Barillari G, Sgadari C, Palladino C, et al. (1999). "Inflammatory cytokines synergize with the HIV-1 Tat protein to promote angiogenesis and Kaposi's sarcoma via induction of basic fibroblast growth factor and the alpha v beta 3 integrin". Journal of Immunology. 163 (4): 1929–35. doi: 10.4049/jimmunol.163.4.1929 . PMID   10438928.
• Carriero MV, Del Vecchio S, Capozzoli M, et al. (1999). "Urokinase receptor interacts with alpha(v)beta5 vitronectin receptor, promoting urokinase-dependent cell migration in breast cancer". Cancer Res. 59 (20): 5307–14. PMID   10537314.
• Tang S, Gao Y, Ware JA (1999). "Enhancement of endothelial cell migration and in vitro tube formation by TAP20, a novel beta 5 integrin-modulating, PKC theta-dependent protein". J. Cell Biol. 147 (5): 1073–84. doi:10.1083/jcb.147.5.1073. PMC   2169340 . PMID   10579726.
• Cirulli V, Beattie GM, Klier G, et al. (2000). "Expression and function of alpha(v)beta(3) and alpha(v)beta(5) integrins in the developing pancreas: roles in the adhesion and migration of putative endocrine progenitor cells". J. Cell Biol. 150 (6): 1445–60. doi:10.1083/jcb.150.6.1445. PMC   2150716 . PMID   10995448.
• Albert ML, Kim JI, Birge RB (2001). "alphavbeta5 integrin recruits the CrkII-Dock180-rac1 complex for phagocytosis of apoptotic cells". Nat. Cell Biol. 2 (12): 899–905. doi:10.1038/35046549. PMID   11146654. S2CID   7535200.
• Zhou M, Graham R, Russell G, Croucher PI (2001). "MDC-9 (ADAM-9/Meltrin gamma) functions as an adhesion molecule by binding the alpha(v)beta(5) integrin". Biochem. Biophys. Res. Commun. 280 (2): 574–80. doi:10.1006/bbrc.2000.4155. PMID   11162558.
• Niu JK, Zhang WJ, Ye LY, Wu LQ, Zhu GJ, Yang ZH, Grau GE, Lou JN (2007). "The role of adhesion molecules, alpha v beta 3, alpha v beta 5 and their ligands in the tumor cell and endothelial cell adhesion". Eur J Cancer Prev. 16 (6): 517–27. doi:10.1097/CEJ.0b013e3280145c00. PMID   18090124. S2CID   1825380.

External links

• ITGB5 Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine