Iodoantipyrine

Iodoantipyrine

Identifiers
IUPAC name 4-iodo-1,5-dimethyl-2-phenylpyrazol-3-one
CAS Number	129-81-7
PubChem CID	8522
ChemSpider	8208
UNII	V30V6H1QX4
ChEMBL	ChEMBL24132
CompTox Dashboard (EPA)	DTXSID7046047
ECHA InfoCard	100.004.516
Chemical and physical data
Formula	C11H11IN2O
Molar mass	314.126 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC1=C(C(=O)N(N1C)C2=CC=CC=C2)I
InChI InChI=1S/C11H11IN2O/c1-8-10(12)11(15)14(13(8)2)9-6-4-3-5-7-9/h3-7H,1-2H3 Key:ZZOBLCHCPLOXCE-UHFFFAOYSA-N

Iodoantipyrine is a drug developed in the 1950s. It has antiinflammatory effects, and also has antiviral action by inducing interferon production. It has been used in Russia for treatment of tick-borne encephalitis, but is more commonly used in recent times in its radiolabelled form for tracking blood flow. ^{[1] [2] [3] [4]}

See also

• Aminophenazone
• Phenazone (Antipyrine)
• Propyphenazone

References

1. Glazer LC. "Methods for determination of optic nerve blood flow". The Yale Journal of Biology and Medicine. 61 (1): 51–60. PMID   3284212.
2. Iavorovskaia VE, Saratikov AS, Fedorov Iu, Solianik RG, Anosova GV, Lepekhin AV, et al. "[Iodoantipyrine--an agent for treating and preventing tick-borne encephalitis]". Eksperimental'naia i Klinicheskaia Farmakologiia. 61 (1): 51–53. PMID   9575413.
3. Krylova NV, Iakusheva SS, Borisevich VG, Leonova GN. "[Changes in the immune status parameters and their correction in various forms of tick-borne encephalitis]". Antibiotiki i Khimioterapiia = Antibiotics and Chemoterapy [Sic]. 46 (7): 23–26. PMID   11697240.
4. Zochodne DW (2002). "Nerve and ganglion blood flow in diabetes: an appraisal". International Review of Neurobiology. 50: 161–202. doi:10.1016/S0074-7742(02)50077-5. ISBN   978-0-12-366850-9. PMID   12198810.