Isocupressic acid

Isocupressic acid
Names
	IUPAC name (13E)-15-Hydroxylabda-8(20),13-dien-19-oic acid
	Systematic IUPAC name (1S,4aR,5S,8aR)-5-[(3E)-5-Hydroxy-3-methylpent-3-en-1-yl]-1,4a-dimethyl-6-methylidenedecahydronaphthalene-1-carboxylic acid
Identifiers
CAS Number	1909-91-7 ;
3D model (JSmol)	Interactive image ;
ChEMBL	ChEMBL511193 ;
ChemSpider	4942630 ;
PubChem CID	6438138 ;
UNII	6DV5EL78HE ;
CompTox Dashboard (EPA)	DTXSID901045341 ;
	InChI InChI=1S/C20H32O3/c1-14(10-13-21)6-8-16-15(2)7-9-17-19(16,3)11-5-12-20(17,4)18(22)23/h10,16-17,21H,2,5-9,11-13H2,1,3-4H3,(H,22,23)/b14-10+/t16-,17+,19+,20-/m0/s1 Key: DOYKMKZYLAAOGH-DOEMEAPXSA-N; InChI=1/C20H32O3/c1-14(10-13-21)6-8-16-15(2)7-9-17-19(16,3)11-5-12-20(17,4)18(22)23/h10,16-17,21H,2,5-9,11-13H2,1,3-4H3,(H,22,23)/b14-10+/t16-,17+,19+,20-/m0/s1 Key: DOYKMKZYLAAOGH-DOEMEAPXBD;
	SMILES O=C(O)[C@]1(CCC[C@@]2([C@H](/C(=C)CC[C@@H]12)CCC(=C/CO)/C)C)C;
Properties
Chemical formula	C20H32O3
Molar mass	320.473 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Last updated June 08, 2025

Isocupressic acid is a diterpene acid present in a variety of conifer needles. It induces abortion in cattle.^[1] It is found in all parts of the ponderosa pine (Pinus ponderosa), especially the needles. This gives its toxic and abortifacient effects.^[2] It is also present in the lodgepole pine (P. contorta), the jeffrey pine (P. jeffreyi) and possibly in the monterey pine (P. radiata).^[3]

References

↑ Wang, S; Panter, KE; Gardner, DR; Evans, RC; Bunch, TD (2004). "Effects of the pine needle abortifacient, isocupressic acid, on bovine oocyte maturation and preimplantation embryo development". Animal Reproduction Science . 81 (3–4): 237–44. doi:10.1016/j.anireprosci.2003.10.008. PMID 14998650. Archived from the original on 2021-06-05. Retrieved 2018-12-29.
↑ Stegelmeier, BL; Gardner, DR; James, LF; Panter, KE; Molyneux, RJ (1996). "The toxic and abortifacient effects of ponderosa pine". Vet. Pathol. 33 (1): 22–8. doi: 10.1177/030098589603300103 . PMID 8826003. S2CID 19523938.
↑ Burrows, George E.; Tyrl, Ronald J. (2012). Toxic Plants of North America (2nd ed.). John Wiley & Sons. ISBN 9781118413388.

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[1] Wang, S; Panter, KE; Gardner, DR; Evans, RC; Bunch, TD (2004). "Effects of the pine needle abortifacient, isocupressic acid, on bovine oocyte maturation and preimplantation embryo development". Animal Reproduction Science . 81 (3–4): 237–44. doi:10.1016/j.anireprosci.2003.10.008. PMID 14998650. Archived from the original on 2021-06-05. Retrieved 2018-12-29.

[2] Stegelmeier, BL; Gardner, DR; James, LF; Panter, KE; Molyneux, RJ (1996). "The toxic and abortifacient effects of ponderosa pine". Vet. Pathol. 33 (1): 22–8. doi: 10.1177/030098589603300103 . PMID 8826003. S2CID 19523938.

[3] Burrows, George E.; Tyrl, Ronald J. (2012). Toxic Plants of North America (2nd ed.). John Wiley & Sons. ISBN 9781118413388.

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[2]

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Names

IUPAC name (13E)-15-Hydroxylabda-8(20),13-dien-19-oic acid
Systematic IUPAC name (1S,4aR,5S,8aR)-5-[(3E)-5-Hydroxy-3-methylpent-3-en-1-yl]-1,4a-dimethyl-6-methylidenedecahydronaphthalene-1-carboxylic acid
Identifiers
CAS Number	1909-91-7 ^N
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL511193
ChemSpider	4942630
PubChem CID	6438138
UNII	6DV5EL78HE ^Y
CompTox Dashboard (EPA)	DTXSID901045341
InChI InChI=1S/C20H32O3/c1-14(10-13-21)6-8-16-15(2)7-9-17-19(16,3)11-5-12-20(17,4)18(22)23/h10,16-17,21H,2,5-9,11-13H2,1,3-4H3,(H,22,23)/b14-10+/t16-,17+,19+,20-/m0/s1 Key: DOYKMKZYLAAOGH-DOEMEAPXSA-N InChI=1/C20H32O3/c1-14(10-13-21)6-8-16-15(2)7-9-17-19(16,3)11-5-12-20(17,4)18(22)23/h10,16-17,21H,2,5-9,11-13H2,1,3-4H3,(H,22,23)/b14-10+/t16-,17+,19+,20-/m0/s1 Key: DOYKMKZYLAAOGH-DOEMEAPXBD
SMILES O=C(O)[C@]1(CCC[C@@]2([C@H](/C(=C)CC[C@@H]12)CCC(=C/CO)/C)C)C
Properties
Chemical formula	C₂₀H₃₂O₃
Molar mass	320.473 g·mol⁻¹
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references