JXL082

Last updated
JXL082
JXL082.svg
Clinical data
Other namesJXL-082
Drug class Mitochondrial pyruvate carrier (MPC) inhibitor
ATC code
  • None
Identifiers
  • ethyl (E)-3-[1-{{#parsoidfragment:1}}3,5-bis(trifluoromethyl)phenyl]methyl]pyrrolo[2,3-b]pyridin-3-yl]-2-cyanoprop-2-enoate
CAS Number
ChEMBL
Chemical and physical data
Formula C22H15F6N3O2
Molar mass 467.371 g·mol−1
3D model (JSmol)
  • CCOC(=O)/C(=C/C1=CN(C2=C1C=CC=N2)CC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)/C#N
  • InChI=1S/C22H15F6N3O2/c1-2-33-20(32)14(10-29)8-15-12-31(19-18(15)4-3-5-30-19)11-13-6-16(21(23,24)25)9-17(7-13)22(26,27)28/h3-9,12H,2,11H2,1H3/b14-8+
  • Key:AIPLDVOUZVHAOG-RIYZIHGNSA-N

JXL082, or JXL-082, is a drug acting as a mitochondrial pyruvate carrier (MPC) inhibitor which was synthesized towards the aim of developing a treatment for hair loss. [1] [2] It is related to other drugs in the same series such as PP405, JXL069, and UK-5099 (JXL001). [1] [2] The drug is known to have been sold online in a grey market fashion for treatment of hair loss. [2] It has been mistakenly believed to be PP405, but PP405 is said not to be JXL082. [2] JXL082 was first described in the scientific literature by 2019. [3] [1]

See also

References

  1. 1 2 3 Liu X, Flores AA, Situ L, Gu W, Ding H, Christofk HR, Lowry WE, Jung ME (February 2021). "Development of Novel Mitochondrial Pyruvate Carrier Inhibitors to Treat Hair Loss". J Med Chem. 64 (4): 2046–2063. doi:10.1021/acs.jmedchem.0c01570. PMC   8939290 . PMID   33534563.
  2. 1 2 3 4 Brown, Lane (12 August 2025). "The Great Unbalding Draws Nearer". Intelligencer. Retrieved 24 October 2025.
  3. ↑ "Compositions and methods for modulating hair growth". Google Patents. 29 June 2018. Retrieved 24 October 2025.
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