Jeanne Marrazzo | |
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6th Director of the National Institute of Allergy and Infectious Diseases | |
Assumed office September 24, 2023 | |
Deputy | Hugh Auchincloss |
Preceded by | Anthony Fauci |
Personal details | |
Education | Radcliffe College (BA) Thomas Jefferson University (MD) University of Washington (MPH) |
Scientific career | |
Fields | Infectious diseases |
Institutions | University of Washington School of Medicine University of Alabama at Birmingham National Institutes of Health |
Thesis | Selective Screening Criteria for Chlamydia Trachomatis Infection in Women Attending Region X Family Planning and STD Clincs:Performance and Cost-Effectiveness (1994) |
Jeanne Marisa Marrazzo is an American physician-scientist and infectious diseases specialist. She was the director of the University of Alabama School of Medicine Division of Infectious Diseases and focused on prevention of HIV infection using biomedical interventions. Marrazzo is a fellow of the American College of Physicians and Infectious Disease Society of America. On August 2,2023 Lawrence A. Tabak,acting director for the National Institutes of Health (NIH),named Jeanne M. Marrazzo as director of NIH’s National Institute of Allergy and Infectious Diseases.
Growing up in Dunmore,Pennsylvania, [1] [2] Marrazzo chose to get into a career in medicine because her mother was a nurse and her role model. [3] She earned her undergraduate degree in biology from Radcliffe College and her medical degree from Jefferson Medical College at Thomas Jefferson University. Marrazzo later completed residency training and chief residency in internal medicine at Yale-New Haven Hospital. [4]
Marrazzo joined the faculty at the University of Washington School of Medicine in 1995. [5] While there,she co-founded the Lesbian/Bisexual Women’s Health Study with nurse practitioner Kathleen Stine after noticing an unusual number of middle-aged women had abnormal Pap smears. The results of their findings secured them funding from the National Institute of Allergy and Infectious Diseases (NIAID) to investigate the prevalence and routes of transmission of various STDs among lesbian and bisexual women. [6] This led to a co-authored study titled Pap Smear Screening and Prevalence of Genital Human Papillomavirus Infection in Women Who Have Sex with Women, which found that out of 300 women in the Seattle area,13 percent tested positive for HPV and 4 percent had pre-cancerous changes on a Pap test. [7] The following year,she was elected a Fellow of the American College of Physicians. [5]
In 2005,Marrazzo co-authored a study with David N. Fredricks and Tina L. Fiedler titled Molecular Identification of Bacteria Associated With Bacterial Vaginosis, which focused on the causes of bacterial vaginosis. [8] In 2008,Marrazzo was appointed a member of the Subspecialty Board on Infectious Disease by the American Board of Internal Medicine (ABIM), [9] and four years later was named its chair. [10] During this time,Marrazzo was elected a Fellow of the Infectious Disease Society of America and Bennett Lorber Visiting Professor at Temple University. [5] From 2009 until 2012,Marrazzo conducted the VOICE (Vaginal and Oral Interventions to Control the Epidemic) Study through the Microbicide Trials Network. The study was a randomized,placebo-controlled trial which examined the effects of daily use of oral tenofovir disoproxil fumarate had on over 5,000 women from 15 sites in South Africa,Uganda and Zimbabwe. [11] The final published paper failed to prove that oral pre-exposure prophylaxis (PrEP) or of a tenofovir-containing vaginal microbicide gel was effective in lowering the risk of HIV. [12]
Considered an expert in the field of HIV prevention,Marrazzo was appointed a co-chair of an interdisciplinary panel of experts to create a guideline in achieving an AIDS-free generation. The guidelines,which were later published in the Journal of the American Medical Association, integrated evidence-based behavioral interventions for people with HIV or at high risk for HIV infection. [13] Her efforts in HIV prevention earned her the 2015 American Sexually Transmitted Diseases Association (ASTDA) Achievement Award [14] and appointment to chair of the American Board of Internal Medicine Council. [15]
In 2016,Marrazzo succeeded Edward W. Hook,III as director of the University of Alabama School of Medicine Division of Infectious Diseases. [16] After stepping down as president of the International Society for STD Research,she was named to the Infectious Diseases Society of America board of directors. [17] On October 23,2019,she was named principal investigator of a three-year $3.5 million grant study from NIAID to test the effectiveness of the Bexsero vaccine in protecting vulnerable populations from gonorrhea. [18] During the COVID-19 pandemic,Marrazzo studied whether blood clots could result in the spread of the virus through the human body. [19] She also oversaw clinical trials of remdesivir as a treatment against COVID-19 at the University of Alabama at Birmingham. [20] [21]
In August 2023,Marrazzo was named director of NIH’s National Institute of Allergy and Infectious Diseases (NIAID),succeeding acting director Hugh Auchincloss. [22] A lesbian,she is the first member of the LGBT community to hold the position. [23]
Bacterial vaginosis (BV) is an infection of the vagina caused by excessive growth of bacteria. Common symptoms include increased vaginal discharge that often smells like fish. The discharge is usually white or gray in color. Burning with urination may occur. Itching is uncommon. Occasionally, there may be no symptoms. Having BV approximately doubles the risk of infection by a number of sexually transmitted infections, including HIV/AIDS. It also increases the risk of early delivery among pregnant women.
Microbicides for sexually transmitted infections are pharmacologic agents and chemical substances that are capable of killing or destroying certain microorganisms that commonly cause sexually transmitted infection.
The National Institute of Allergy and Infectious Diseases is one of the 27 institutes and centers that make up the National Institutes of Health (NIH), an agency of the United States Department of Health and Human Services (HHS). NIAID's mission is to conduct basic and applied research to better understand, treat, and prevent infectious, immunologic, and allergic diseases.
The HIV Prevention Trials Network (HPTN) is a worldwide collaborative clinical trials network that brings together investigators, ethicists, community and other partners to develop and test the safety and efficacy of interventions designed to prevent the acquisition and transmission of HIV. HPTN studies evaluate new HIV prevention interventions and strategies in populations and geographical regions that bear a disproportionate burden of infection. The HPTN is committed to the highest ethical standards for its clinical trials and recognizes the importance of community engagement in all phases of the research process.
The Vaccine Research Center (VRC), is an intramural division of the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), US Department of Health and Human Services (HHS). The mission of the VRC is to discover and develop both vaccines and antibody-based products that target infectious diseases.
Barton Ford Haynes is an American physician and immunologist internationally recognized for work in T-cell immunology, retrovirology, and HIV vaccine development. Haynes is a Frederic M. Hanes Professor of Medicine and Immunology at Duke University Medical Center. He is the director of the Duke Human Vaccine Institute and the Duke Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID), which was funded by the National Institute of Allergy and Infectious Diseases (NIAID) in 2012. In addition, Haynes directs the B-cell Lineage Envelope Design Study, the Centralized Envelope Phase I Study, and the Role of IgA in HIV-1 Protection Study as part of the Collaboration for AIDS Vaccine Discovery (CAVD), which was funded by the Bill and Melinda Gates Foundation in 2006.
CAPRISA 004 is the name of a clinical trial conducted by CAPRISA. This particular study was the first to show that a topical gel could reduce a person's risk of contracting HIV. The gel used in the study contained a microbicide.
Zeda Fran Rosenberg is an American microbiologist and epidemiologist, active in HIV biology and prevention. She is the chief executive officer of the International Partnership for Microbicides (IPM). IPM was founded by Rosenberg in 2002 and is a nonprofit organization dedicated to developing microbicides and other innovative HIV prevention products and making them available for women in developing countries.
CONRAD is a non-profit scientific research organization that works to improve global and reproductive health, particularly in women in developing countries. CONRAD was established in 1986 under a cooperative agreement between Eastern Virginia Medical School (EVMS) and the United States Agency for International Development (USAID). CONRAD’s products are developed primarily for women in low-resource settings, in that they are designed to be safe, affordable and user-friendly. CONRAD is led by Scientific and Executive Director Gustavo F. Doncel, M.D., Ph.D. Primary funding for CONRAD comes from the U.S. President's Emergency Plan for AIDS Relief (PEPFAR) through the U.S. Agency for International Development (USAID), with additional funding from The Bill & Melinda Gates Foundation and the National Institutes of Health (NIH).
Jeffrey P. Nadler was an American Infectious Diseases and HIV/AIDS expert. His most recent position had been as Acting Director and Assistant Director of the Therapeutics Research Program, Division of AIDS (DAIDS), National Institute of Allergy and Infectious Diseases (NIAID) where he oversaw NIH/NIAID-sponsored national and international HIV/AIDS research.
A rectal microbicide is a microbicide for rectal use. Most commonly such a product would be a topical gel inserted into the anus so that it make act as protection against the contract of a sexually transmitted infection during anal sex.
A vaginal microbicide is a microbicide for vaginal use, generally as protection against the contraction of a sexually transmitted infection during vaginal sexual intercourse. Vaginal microbicides are topical gels or creams inserted into the vagina.
The Microbicide Trials Network was a United States government-funded research organization working in the field of microbicides for sexually transmitted diseases. The MTN focused on research into microbicides which would prevent HIV infection. The MTN was a member of HANC. After its closure, partner organization HIV Prevention Trials Network took control of its projects.
Quarraisha Abdool Karim is an infectious diseases epidemiologist and co-founder and Associate Scientific Director of CAPRISA. She is a Professor in Clinical Epidemiology, Columbia University, New York and Pro-Vice Chancellor for African Health, University of KwaZulu-Natal, South Africa.
Lactobacillus jensenii is a lactic acid bacteria species in the genus Lactobacillus.
HPTN 083 is a 2016 clinical trial which compares cabotegravir injections with oral use of Emtricitabine/tenofovir as pre-exposure prophylaxis ("PrEP") for prevention of HIV/AIDS.
Sharon Louise Hillier is an American microbiologist. She is the Richard Sweet Endowed Chair in Reproductive Infectious Disease and vice chair of the department of obstetrics, gynecology and reproductive sciences at the University of Pittsburgh Medical Center (UPMC) and Magee-Women's Research Institute.
Hugh Auchincloss, Jr. is an American immunologist and physician who served as the acting director of the National Institute of Allergy and Infectious Diseases from January to August 2023. Previously, he was the principal deputy director of the NIAID, from 2006 to 2022. Prior to government service, Auchincloss was a transplant surgeon and full professor of surgery at Harvard Medical School, and researched at Massachusetts General Hospital for 17 years.
John R. Mascola is an American physician-scientist, immunologist and infectious disease specialist. He was the director of the Vaccine Research Center (VRC), part of the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH). He also served as a principal advisor to Anthony Fauci, director of NIAID, on vaccines and biomedical research affairs. Mascola is the current Chief Scientific Officer for ModeX Therapeutics.
Lisa Cencia Rohan is an American chemist and pharmaceutical scientist.
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