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Cagrilintide/semaglutide, marketed as CagriSema, is a combination of cagrilintide, a dual amylin and calcitonin receptor agonist, and semaglutide, a GLP-1 agonist. It is injected once weekly and is being tested in type 2 diabetes and obesity. Preliminary trial results found a greater weight loss compared to either medication alone. HbA1c was significantly improved compared to cagrilintide alone and non-significantly better than semaglutide alone. In a Phase II trial, weight loss averaged -15.6 percent after 32 weeks, making CagriSema comparable in efficacy to tirzepatide. A future trial sponsored by Novo Nordisk is comparing tirzepatide and CagriSema head-to-head. As of 2023, CagriSema is in a Phase III trial, compare the safety and efficacy of CagriSema Injection with Semaglutide in obese and overweight patients.
Lotte Bjerre Knudsen is a Danish scientist and university professor. She led the development of liraglutide and semaglutide, two notable drugs approved for indications in the treatment of diabetes and obesity.
Arne Vernon Astrup is a Danish nutritionist, chief physician, researcher, author and professor. He is known as a researcher, communicator and author and has published more than 900 scientific articles. In 2018 he was internationally recognised as one of the world's most cited researchers. Arne Astrup has contributed to the identification of GLP-1 as a satiety hormone, which has played a key role in the development of GLP-1 drugs for the treatment of obesity, which has contributed to the success of Novo Nordisk A/S and their drug Wegovy.
References
- ↑ Singh G, Krauthamer M, Bjalme-Evans M (January 2022). "Wegovy (semaglutide): a new weight loss drug for chronic weight management". Journal of Investigative Medicine. 70 (1): 5–13. doi:10.1136/jim-2021-001952. PMC 8717485 . PMID 34706925.
- ↑ Astrup, Arne (2024). "Reflections on the discovery GLP-1 as a satiety hormone: Implications for obesity therapy and future directions". European Journal of Clinical Nutrition. 78 (7): 551–556. doi:10.1038/s41430-024-01460-6. ISSN 0954-3007. PMID 38890501.
- ↑ Prize Recipients | Warren Alpert Foundation Prize
- ↑ "2021 Canada Gairdner Awards Recognize World-Renowned Scientists For Transformative Contributions To Research Impacting Human Health". 7 April 2021. Retrieved 13 December 2021.
- ↑ "Exceptional Leaders in Diabetes Research, Prevention and Treatment to be Recognized at ADA's 81st Scientific Sessions" (PDF; 269 kB). diabetes.org. American Diabetes Association. 2021-03-08.
- ↑ "Daniel J. Drucker, Jeffrey M. Friedman, Joel F. Habener, Jens Juul Holst, and Svetlana Mojsov, Princess of Asturias Award for Technical and Scientific Research 2024". Princess of Asturias Foundation. 5 June 2024.
- ↑ Tang Prize 2024
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