Arne Astrup

Last updated
Arne Vernon Astrup
Born (1955-08-01) 1 August 1955 (age 69)
Frederiksberg, Denmark
NationalityDanish
Alma mater University of Copenhagen
Scientific career
Fields
Institutions University of Copenhagen, Novo Nordisk Foundation

Arne Vernon Astrup (born August 1, in Frederiksberg, 1955) is a Danish nutritionist, chief physician, researcher, author and professor. He is known as a researcher, communicator and author and has published more than 900 scientific articles. [1] In 2018 he was internationally recognised as one of the world's most cited researchers. [2] Arne Astrup has contributed to the identification of GLP-1 as a satiety hormone, [3] which has played a key role in the development of GLP-1 drugs for the treatment of obesity, [4] which has contributed to the success of Novo Nordisk A/S and their drug Wegovy. [5]

Contents

From 1990 to 2020 was head of the Department of Nutrition, Exercise and Sports at the Faculty of Science at the University of Copenhagen. In the fall of 2016, the department was ranked by the internationally recognised Shanghai Ranking as the world's leading research environment in its field. [6]

Astrup completed his medical studies at the University of Copenhagen in 1981. In 1986, he received his medical doctorate (Dr. med.) for his dissertation on metabolism in humans. [7] Subsequently, he continued his training as a specialist in Internal Medicine. He was at the final stage of his specialist training when he became head of the Danish Royal Veterinary and Agricultural University in 1990. He was made a Knight of the Order of Dannebrog in 1999 by Her Majesty Queen Margrethe II of Denmark, and Knight 1st Class of the Order of Dannebrog in 2012. [8]

Since July 1, 2020, Arne Astrup has taken on the role of Senior Vice President, Obesity and Nutritional Sciences, at the Novo Nordisk Foundation. [2]

Career and recognitions

Arne Astrup has achieved national and international recognition since the 1990s. He is known for being one of the most cited researchers in the world. His work in the intersection between industry and academia has resulted in several controversies [9] that have made his name publicly known in the wider Danish population. [10]

Recognitions

Arne Astrup's research

Arne Astrup has a background in nutrition research, where he has worked with both experimental physiological and biochemical research as well as clinical treatment trials with subjects and patients. His scientific work has contributed to the understanding of human appetite regulation and energy metabolism, which has led to insights into adipose tissue deposition and body weight. [11] [5]

GLP-1 as a satiety hormone in humans

In collaboration with Professor Jens Juul Holst, he discovered that GLP-1 acts as a satiety hormone in humans. [3] [5] This discovery has played a key role in the development of GLP-1 drugs for the treatment of obesity, which has contributed to the success of Novo Nordisk A/S and their drug Wegovy.

Arne Astrup has published numerous scientific articles in recognized international journals such as The Lancet, British Medical Journal, Nature [8] and New England Journal of Medicine. In 2018, he was included in the Web of Science list of the world's most cited scientists. [7]

Throughout his career, Astrup has also been a dedicated supervisor for 42 PhD students [5] and has contributed to research through an interdisciplinary perspective since his student days.

Activity

Despite being a department head for decades and hence not expected to be actively researching, Arne Astrup has published more than 900 scientific publications, as well as a number of scientific and popular science books throughout his career. As a result, in 2010 he was ranked number 5 in the international ranking of the world's most productive researchers in the field of overweight and obesity by ISIS Reuters. He is also a frequent contributor to leading medical journals such as The Lancet, New England Journal of Medicine and American Journal of Clinical Nutrition. Professionally, he is a trendsetter, which is why in 2018 he was included in Clarivate's exclusive list of the most cited researchers in the world. [5] [7] A list that only 32 other researchers at the University of Copenhagen have made. He has also written columns and letters to the editor in Ekstra Bladet, 24 Timer and Ude og Hjemme, among others. He has received numerous honors for his research and was appointed Knight of Dannebrog in 1991 and Knight of the Order of Dannebrog 1st degree in 2012.

Through his work as head of the Department of Human Nutrition (and since 2012 the Department of Nutrition, Exercise and Sports), Arne Astrup has had a significant influence on the development of the field of nutrition, including being the initiator of establishing the Master's programs in Human Nutrition, as well as Clinical Nutrition at the Danish Royal Veterinary and Agricultural University (since 2007 part of the University of Copenhagen).

Arne Astrup is behind the EU diet project “Diogenes”, [12] supported by the EU Framework Program with 15 million euros, which showed that a diet with more protein and fewer carbohydrates could promote weight control in overweight people after weight loss. Together with Master of Science in Human Nutrition Christian Bitz, he has disseminated the principles of Diogenes in the book “The World's Best Diet”, which has sold over 100,000 copies and has been translated into 4 languages.

Criticism and Controversies

Astrup has faced criticism for combining his research responsibilities with personal economic interests on several occasions. For instance, he held a dual role with the company Neurosearch, acting as an advisor and owning stocks while publicly endorsing the company’s diet pill in his column, "Doktor Slank" ("Doctor Skinny"). [13] This raised concerns about potential conflicts of interest. Following the negative publicity, Astrup sold his shares in Neurosearch, which were valued at approximately DKK 200,000. [13] He maintains that he was able to keep his professional and personal interests separate.

Awards and Honours

Arne Astrup has received a number of Danish and international awards throughout his career, including:

YearAward
1990Danish Obesity Research Award
1990Servier’s Award for Outstanding Obesity Research [14] [15]
1994IASO Andrew Mayer Award [15]
1995Mölnlycke Life Quality Award
2002Danone Chair in Nutrition 2002 at The University of Antwerp [14]
2007University of Copenhagen: Communications Award [16]
2009International Association of Business Communicators’ EME Excel Merit Award for Communication Leadership [14]
2010University of Copenhagen: Innovation Award [17]
2010Nutrition & Santé Weight Management Award (France) [14]
2012Finnish Association of Internal Medicine Esko Nikkilä Prize [18]
2012American Society for Nutrition Robert H. Herman Award [19] [20]
2012Danish Communication Association KomPris´12 to the OPUS Research Centre [14]
2014IASO Willendorf Award [5]

Authorship

Arne Astrup has published several books together with other authors such as Claus Meyer, Christian Bitz, Mads Fiil Hjorth and others. [21]

YearTitleAkuthors
2018Type C - Spis dig slank efter BlodsukkerkurenArne Astrup, Christian Bitz, Mads Fiil Hjorth
2017Spis dig slank efter dit blodsukkerArne Astrup, Christian Bitz
2017Type A - spis dig slank efter dit blodsukkerArne Astrup, Christian Bitz, Mads Fiil Hjorth
2017Type B - spis dig slank efter dit blodsukkerArne Astrup, Christian Bitz, Mads Fiil Hjorth
2017Type A - spis dig slank efter dit blodsukkerArne Astrup, Christian Bitz, Mads Fiil Hjorth
2017The Nordic Way Jennie Brand-Miller, Arne Astrup, Christian Bitz
2016Til ØlletArne Astrup, Erik Skovenborg
2015Rigtig MadArne Astrup, Thilde Jo Maarbjerg, Thomas Rode Andersen
2014Verdens sundeste mor og barnArne Astrup, Christian Bitz
2012Verdens Bedste KurArne Astrup, Christian Bitz
2012Verdens bedste kur vol. 2.0Arne Astrup, Christian Bitz
2007Spis IgennemArne Astrup, Claus Meyer
2004100 spørgsmål til professoren - og 100 svar. Slankeguiden 2004Arne Astrup


Related Research Articles

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The Atkins diet is a low-carbohydrate fad diet devised by Robert Atkins in the 1970s, marketed with claims that carbohydrate restriction is crucial to weight loss and that the diet offered "a high calorie way to stay thin forever".

<span class="mw-page-title-main">Anti-obesity medication</span> Class of pharmacological agents

Anti-obesity medication or weight loss medications are pharmacological agents that reduce or control excess body fat. These medications alter one of the fundamental processes of the human body, weight regulation, by: reducing appetite and consequently energy intake, increasing energy expenditure, redirecting nutrients from adipose to lean tissue, or interfering with the absorption of calories.

<span class="mw-page-title-main">Novo Nordisk</span> Danish pharmaceutical company

Novo Nordisk A/S is a Danish multinational pharmaceutical company headquartered in Bagsværd with production facilities in nine countries and affiliates or offices in five countries. Novo Nordisk is controlled by majority shareholder Novo Holdings A/S which holds approximately 28% of its shares and a majority (77%) of its voting shares.

Specific dynamic action (SDA), also known as thermic effect of food (TEF) or dietary induced thermogenesis (DIT), is the amount of energy expenditure above the basal metabolic rate due to the cost of processing food for use and storage. Heat production by brown adipose tissue which is activated after consumption of a meal is an additional component of dietary induced thermogenesis. The thermic effect of food is one of the components of metabolism along with resting metabolic rate and the exercise component. A commonly used estimate of the thermic effect of food is about 10% of one's caloric intake, though the effect varies substantially for different food components. For example, dietary fat is very easy to process and has very little thermic effect, while protein is hard to process and has a much larger thermic effect.

<span class="mw-page-title-main">David Ludwig (physician)</span> American physician

David S. Ludwig is an American endocrinologist and low-carbohydrate diet advocate in Boston, Massachusetts. He is a promoter of functional medicine.

<span class="mw-page-title-main">Very-low-calorie diet</span> Diet with very or extremely low daily food energy consumption

A very-low-calorie diet (VLCD), also known as semistarvation diet and crash diet, is a type of diet with very or extremely low daily food energy consumption. VLCDs are defined as a diet of 800 kilocalories (3,300 kJ) per day or less. Modern medically supervised VLCDs use total meal replacements, with regulated formulations in Europe and Canada which contain the recommended daily requirements for vitamins, minerals, trace elements, fatty acids, protein and electrolyte balance. Carbohydrates may be entirely absent, or substituted for a portion of the protein; this choice has important metabolic effects. Medically supervised VLCDs have specific therapeutic applications for rapid weight loss, such as in morbid obesity or before a bariatric surgery, using formulated, nutritionally complete liquid meals containing 800 kilocalories or less per day for a maximum of 12 weeks.

<span class="mw-page-title-main">Liraglutide</span> Anti-diabetic medication

Liraglutide, sold under the brand names Victoza and Saxenda among others, is an anti-diabetic medication used to treat type 2 diabetes, and chronic obesity. It is a second-line therapy for diabetes following first-line therapy with metformin. Its effects on long-term health outcomes like heart disease and life expectancy are unclear. It is given by injection under the skin.

Glucagon-like peptide-1 (GLP-1) receptor agonists, also known as GLP-1 analogs, GLP-1DAs or incretin mimetics, are a class of anorectic drugs that reduce blood sugar and energy intake by activating the GLP-1 receptor. They mimic the actions of the endogenous incretin hormone GLP-1 that is released by the gut after eating.

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The carbohydrate-insulin model (CIM) posits that obesity is caused by excess consumption of carbohydrate, which then disrupts normal insulin metabolism leading to weight gain and weight-related illnesses. It is contrasted with the mainstream energy balance model (EBM), which holds that obesity is caused by an excess in calorie consumption compared to calorie expenditure. According to the carbohydrate–insulin model, low-carbohydrate diets would be the most effective in causing long-term weight loss. Notable proponents of the carbohydrate–insulin model include Gary Taubes and David Ludwig. The CIM has been tested in mice and humans. Although some experts consider that these studies falsified the CIM, proponents disagree. Available evidence does not support the existence of a long-term advantage in weight loss for low-carbohydrate diets.

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Jens Juul Holst is a Danish physician and physiologist. He is known for discovering and describing the hormone glucagon-like peptide-1 (GLP-1), a hormone in the gut that plays an important role in the onset and development of Type 2 diabetes. In collaboration with researcher and author Arne Astrup, he discovered that GLP-1 acts as a satiety hormone in humans.

References

  1. "Arne Astrup". scholar.google.com. Retrieved 2024-07-30.
  2. 1 2 3 "Professor Arne Astrup to head ambitious initiative promoting healthy weight among children". Novo Nordisk Fonden. Retrieved 2024-07-30.
  3. 1 2 Astrup, Arne (July 2024). "Reflections on the discovery GLP-1 as a satiety hormone: Implications for obesity therapy and future directions". European Journal of Clinical Nutrition. 78 (7): 551–556. doi:10.1038/s41430-024-01460-6. ISSN   1476-5640. PMC   11230893 . PMID   38890501.
  4. 1 2 Astrup, Arne (July 2024). "Reflections on the discovery GLP-1 as a satiety hormone: Implications for obesity therapy and future directions". European Journal of Clinical Nutrition. 78 (7): 551–556. doi:10.1038/s41430-024-01460-6. ISSN   1476-5640. PMC   11230893 . PMID   38890501.
  5. 1 2 3 4 5 6 7 8 Swiss RE - Arne Astrup: https://www.swissre.com/profile/Arne_Astrup/ep_3b340a
  6. Madsen, Kristian Levring (2023-10-18). "The University of Copenhagen is among the world's best research environments in Sport Science". nexs.ku.dk. Retrieved 2024-07-30.
  7. 1 2 3 4 American Journal of Nutrition: Meet the AJCN Editorial Board - https://ajcn.nutrition.org/editorialboard
  8. 1 2 3 4 5 6 7 8 9 "Editorial Board | European Journal of Clinical Nutrition". www.nature.com. Retrieved 2024-07-30.
  9. AJCN Nutrion: Conflict of Interest Statements for AJCN Editors - https://ajcn.nutrition.org/content/conflict-of-interest-statements
  10. FROM_OLD_SITE, MIGRATED_ARTICLES (2009-07-28). "Weight loss hero or sweet-toothed villain?". University Post – Independent of management (in Danish). Retrieved 2024-07-30.
  11. "Arne Astrup". www.arlafoodsingredients.com. Retrieved 2024-07-30.
  12. Papadaki, Angeliki; Linardakis, Manolis; Plada, Maria; Larsen, Thomas M.; van Baak, Marleen A.; Lindroos, Anna Karin; Pfeiffer, Andreas F. H.; Martinez, J. Alfredo; Handjieva-Darlenska, Teodora; Kunešová, Marie; Holst, Claus; Saris, Wim H. M.; Astrup, Arne; Kafatos, Anthony; Diet, Obesity and Genes (DiOGenes) Project (2013). "A multicentre weight loss study using a low-calorie diet over 8 weeks: regional differences in efficacy across eight European cities". Swiss Medical Weekly. 143: w13721. doi:10.4414/smw.2013.13721. ISSN   1424-3997. PMID   23348658.
  13. 1 2 Baggersgaard, Claus (2009-07-28). "Weight loss hero or sweet-toothed villain?". University Post – Independent of management (in Danish). Retrieved 2024-08-03.
  14. 1 2 3 4 5 Milknutritiousbynature.com: Symposia, September 2014 - http://www.milknutritiousbynature.eu/fileadmin/milk/Document_Library/RS14_Biographies.pdf
  15. 1 2 "https://www.gelesis.com/2013/03/01/obesity-clinician-arne-astrup-former-president-of-the-international-association-for-the-study-of-obesity-joins-gelesis-advisory-board/" . Retrieved 2024-08-03.{{cite web}}: External link in |title= (help)
  16. Sundhed, Center for Holdspil og (2012-12-06). "Tilknyttede medarbejdere". holdspil.ku.dk (in Danish). Retrieved 2024-08-03.
  17. Ernæring, Institut for Idræt og (2012-10-09). "Ansatte". nexs.ku.dk (in Danish). Retrieved 2024-08-03.
  18. Nutrition, Exercise and Sports (2012-10-09). "Staff". nexs.ku.dk. Retrieved 2024-08-03.
  19. American Society for Nutrition Awards Recipients: https://nutrition.org/wp-content/uploads/2017/08/American-Society-for-Nutrition-Awards_Prior-Recipients.pdf
  20. Ernæring, Institut for Idræt og (2012-10-09). "Ansatte". nexs.ku.dk (in Danish). Retrieved 2024-08-03.
  21. "Books by Arne Astrup (Author of The Nordic Way)". www.goodreads.com. Retrieved 2024-08-03.