Jeffrey I. Gordon

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Jeffrey I. Gordon
Born (1947-10-04) October 4, 1947 (age 77)
New Orleans, LA
Nationality American
Alma mater Oberlin College
University of Chicago School of Medicine
Known forCharacterizing role of human gut microbiome in health and disease
Awards Louisa Gross Horwitz Prize (2017)
Copley Medal (2018)
Balzan Prize (2021)
Princess of Asturias Award (2023)
Albany Medical Center Prize (2023)
Scientific career
Fields Biomedical Science
Institutions Washington University School of Medicine
Website gordonlab.washu.edu

Jeffrey I. Gordon [1] (born October 4, 1947) is a biologist and the Dr. Robert J. Glaser Distinguished University Professor and Director of The Edison Family Center for Genome Sciences & Systems Biology at Washington University School of Medicine. [2] He is internationally known for his research on gastrointestinal development [3] and for founding the field of human microbiome research. [4] His research has revolutionized our understanding of the human microbiome and its roles in health and disease, particularly with regard to nutrition, digestion and metabolism. [5] [6]

Contents

Gordon’s research has significantly advanced scientific understanding of the human gut microbiome as a microbial “organ” that affects human health and disease beyond gastrointestinal health. [7] Much of his work has focused on addressing the global health challenge of childhood undernutrition. [3] Central questions that Gordon and his lab are pursuing include how our gut microbial communities influence human health, what interventions will repair microbial communities for an individual or a population to optimize healthy development, and how to create local infrastructures to deliver treatment in affordable, culturally acceptable, appetizing foods. [8] He and his team identified underdeveloped gut microbiota as a contributing cause of childhood malnutrition [9] and found that therapeutic food aimed at repairing the gut microbiome is superior to a widely used standard therapeutic food to treat childhood malnutrition. [10] Unlike standard therapeutic foods, these microbiome-directed foods improve long-term effects of malnutrition, including problems with metabolism, bone growth, immune function and brain development. [10]

Gordon has been elected to the National Academy of Sciences (2001), [11] the American Academy of Arts and Sciences (2004), [12] the National Academy of Medicine (2008), [13] and the American Philosophical Society (2014). [14]

Education and career

Gordon received his bachelor's degree in Biology at 1969 at Oberlin College in Ohio. Over the next four years, Gordon received his medical training at the University of Chicago and graduated with honors in 1973. After two years as intern and junior assistant resident in Medicine at Barnes Hospital (now Barnes-Jewish Hospital), St. Louis, Gordon joined the Laboratory of Biochemistry at the National Cancer Institute as a Research Associate in 1975. He returned to Barnes Hospital in 1978 to become Senior Assistant Resident and then Chief Medical Resident at Washington University Medical Service. In 1981 he completed a fellowship in medicine (Gastroenterology) at Washington University School of Medicine. In the following years, Gordon rose quickly through the academic ranks at Washington University: Asst. Prof. (1981–1984); Assoc. Prof. (1985–1987); Prof. (1987–1991) of Medicine and Biological Chemistry. In 1991, he became head of the Department of Molecular Biology and Pharmacology (1991–2004). Gordon is currently the Director of The Edison Family Center for Genome Sciences & Systems Biology (2004–present) at Washington University in St. Louis.

Early scientific research

Gordon's early work focused on how the gastrointestinal epithelium is continuously renewed throughout life, and how its component cell types express different functions as they differentiate depending upon where they are located along the length of the gut. [15] [16] [17] This early work employed transgenic mice to study regulation of developmental-stage specific, cell type-specific and spatial patterns of gene expression using members of the fatty acid binding protein gene family as models. [16] [17]

During this time he also  played a pivotal role in the study of protein N-myristoylation, a process by which the 14 carbon fatty acid, myristate, is covalently attached to an N-terminal glycine residue of proteins involved in cell signaling and other functions. Gordon’s group was instrumental in characterizing the substrate specificity of N-myristoyltransferase (Nmt), its catalytic mechanism and its atomic structure. [18] His genetic and biochemical studies provided evidence that Nmt is essential for the viability of fungi that are opportunistic pathogens and yielded enzyme inhibitors that functioned as anti-fungal agents. [18]

The Gordon lab’s transgenic and genetic mosaic mouse models provided evidence that spatial patterns of gene expression in gut epithelial cell lineages were dependent in part on cues from the environment. [19] In the early 1990s, he turned to the gut’s community of micro-organisms (microbiota) and their collective genes (microbiome) to search for these cues. In a simplified model of the human gut ecosystem that employed germ-free mice colonized with a single prominent human gut bacterial symbiont (Bacteroides thetaiotaomicron), his lab showed that this bacterium could direct a postnatal developmental program of expanding production of fucose-containing polysaccharides in the small intestinal epithelium but only if the organisms had functional genes for utilizing these host polysaccharides. [20] [21] His follow-up functional genomics study of gnotobiotic mice colonized with just B. thetaioatomicron disclosed how a gut symbiont could influence many other aspects of gut biology. [22] By sequencing the B. thetaiotaomicron genome, [23] they found a repertoire of genes encoding enzymes that degrade polysaacharides; the number and type of these enzymes greatly exceeded those encoded in the human genome. This information enabled them to show in gnotobiotic mice how this organism can adaptively forage dietary and host glycans depending upon the diets they consumed. [24] B. thetaiotaomicron has subsequently become a leading model organism for dissecting the genetic and metabolic underpinnings of the symbiotic relationship between members of the gut microbiota and their human hosts – including how members sense/acquire/metabolize dietary polysaccharides.

These findings led his group to colonize germ-free animals with defined microbial communities of increasing complexity composed of cultured, genome-sequenced human gut microbiota members, so that questions about how members cooperate and compete in different nutrient environments to shape host physiology could be addressed. Encouraged by results obtained from these types of models, Gordon was lead author of an influential 2005 National Human Genome Research Institute white-paper entitled “Extending Our View of Self: the Human Gut Microbiome Initiative (HGMI)”. [25] In 2007, the Human Microbiome Project was listed on the NIH Roadmap for Medical Research as one of the New Pathways to Discovery.

Gordon’s efforts to link gut microbiome function to nutritional status initially focused on obesity and its associated metabolic dysfunction. This work involved characterization and subsequent transplantation of gut microbial communities from obese and lean mice, and later obese and lean twins including twin pairs discordant for obesity, into germ-free mice to characterize the effects of diet components on microbial community function and host physiology and metabolism. [26] [27] [28] [29] [30] [31] These preclinical models and subsequent pilot clinical studies have been used to develop microbiome-targeted snack food prototypes composed of combinations of polysaccharides from sustainable sources that could improve microbiome function. [32] [33] [34]

Current research

Gordon and his team are characterizing the role of the gut microbiome in childhood undernutrition (wasting, stunting or a combination of the two), testing the hypothesis that healthy growth of infants and children depends in part on coordinated co-development of the gut microbiome and host organ systems. [35] [36] Gordon’s work indicates that the healthy development of microbial communities in the gut during infancy is correlated with a child’s healthy growth and development overall. [37]

Birth cohort studies performed by Gordon and collaborators, primarily in Bangladesh in collaboration with Tahmeed Ahmeed at the International Centre for Diarrhoeal Disease Research, Bangladesh (iccdr,b), [38] [39] as well as studies of Malawian twins showing significant difference (discordance) for undernutrition, [40] [41] identified that a normal program of postnatal gut microbiota development in healthy individuals is disrupted in undernourished children. Their research further showed that the disrupted microbial communities of undernourished children are not repaired with current nutritional interventions. [42] [43] [44] [45] By transplanting microbiota from healthy and undernourished children into germ-free mice fed diets of the human microbiota donors, Gordon’s lab identified bacterial strains associated with key facets of postnatal growth and development. [46] These strains become therapeutic targets for repairing the microbial communities of undernourished children. [47] [48]

To develop affordable and scalable treatments, Gordon and his group used gnotobiotic mice and piglets to screen combinations of foods given to 12-18-month-old Bangladeshi children. The microbial communities of the test animals were colonized with gut microbial organisms from undernourished Bangladeshi children. [49] [50] This effort yielded microbiota-directed food (MDCFs) prototypes that modulated the fitness and expressed metabolic activities of targeted age-and growth-discriminatory bacterial strains. Randomized controlled clinical trials performed in Bangladeshi children with wasting showed that compared to a commonly used therapeutic food (ready-to-use supplementary food), the microbiota-directed food produced significantly greater growth, even though its caloric density was lower than that of the traditional therapeutic food. [51] [52] [53] [54] Additionally, this superior growth response was accompanied by superior microbiota repair and alterations in levels of plasma protein biomarkers and mediators of musculoskeletal development, neurodevelopment, metabolism, and immune function. [55] [56] [57] Gordon’s team has also identified the bioactive components of the microbiota-directed food, their microbial therapeutic targets, and how these microbial targets can produce novel metabolic effectors of host physiology. [58] [59] [60]

Together with studies of Bangladeshi infants with severe wasting [61] and of the small intestinal microbiota of stunted Bangladeshi children, [62] this work has revealed a causal link between gut microbiome development in the first years of life, and healthy growth and development in children. “When a child’s gut microbiome is underdeveloped, their overall growth can stagnate, leading to malnutrition with further detrimental effects on immunity, metabolism, bone growth and brain development,” Gordon has said. [63] He has further said there is a critical window in early childhood when interventions with beneficial foods could help shape the development of the gut microbiome in a way that promotes healthy growth overall. [64] Gordon and his team’s work also has yielded a generally applicable translational medicine pipeline for establishing whether disruptions in microbiome composition and expressed functions are related to disease states, and for linking the molecular components of food and microbiome function to human health.

Selected honors

Major awards and honors received by Gordon include:

References

  1. ↑ Akademien
  2. ↑ "Gordon CV". Lab of Jeffrey I. Gordon | WashU Medicine. June 26, 2020. Archived from the original on December 3, 2024. Retrieved February 25, 2025.
  3. 1 2 Lewis, Talia (September 15, 2022). "Jeffrey Gordon Receives Inaugural Hamburg Award for Pioneering Contributions to Microbiome Research - National Academy of Medicine". National Academy of Medicine. Archived from the original on September 27, 2023. Retrieved February 25, 2025.
  4. ↑ "Jeffrey I. Gordon: 2021 Balzan Prize for Microbiome in Health and Disease". Fondazione Internazionale Premio Balzan. Retrieved February 25, 2025.
  5. ↑ "Jeffrey I. Gordon: 2021 Balzan Prize for Microbiome in Health and Disease". Fondazione Internazionale Premio Balzan. Retrieved February 25, 2025.
  6. ↑ "Jeffrey I. Gordon, Peter Greeberg and Bonnie L. Bassler, Princess of Asturias Award for Technical and Scientific Research". Fundación Princesa de Asturias. July 6, 2023. Archived from the original on February 25, 2025. Retrieved February 25, 2025.
  7. ↑ Strait, Julia Evangelou (February 8, 2024). "Gordon receives Nemmers Prize". WashU Medicine. Retrieved February 25, 2025.
  8. ↑ "Jeffrey I. Gordon". Research Profiles at Washington University School of Medicine. Retrieved February 25, 2025.
  9. ↑ Strait, Julia Evangelou (February 18, 2016). "Targeting gut microbes may reverse effects of childhood malnutrition". WashU Medicine. Retrieved February 25, 2025.
  10. 1 2 Strait, Julia Evangelou (December 13, 2023). "Gut bacteria of malnourished children benefit from key elements in therapeutic food". WashU Medicine. Retrieved February 25, 2025.
  11. 1 2 "Jeffrey I. Gordon – NAS". nasonline.org. Retrieved February 21, 2025.
  12. 1 2 "Jeffrey Ivan Gordon | American Academy of Arts and Sciences". www.amacad.org. February 4, 2025. Retrieved February 21, 2025.
  13. 1 2 "Dr. Jeffrey I Gordon". National Academy of Medicine. February 21, 2025. Retrieved February 21, 2025.
  14. 1 2 "APS Member History". search.amphilsoc.org. Retrieved March 12, 2021.
  15. ↑ Mills, Jason C.; Andersson, Niklas; Hong, Chieu V.; Stappenbeck, Thaddeus S.; Gordon, Jeffrey I. (November 12, 2002). "Molecular characterization of mouse gastric epithelial progenitor cells". Proceedings of the National Academy of Sciences of the United States of America. 99 (23): 14819–14824. Bibcode:2002PNAS...9914819M. doi: 10.1073/pnas.192574799 . ISSN   0027-8424. PMC   137502 . PMID   12409607.
  16. 1 2 Mysorekar, Indira U.; Lorenz, Robin G.; Gordon, Jeffrey I. (October 4, 2002). "A gnotobiotic transgenic mouse model for studying interactions between small intestinal enterocytes and intraepithelial lymphocytes". The Journal of Biological Chemistry. 277 (40): 37811–37819. doi: 10.1074/jbc.M205300200 . ISSN   0021-9258. PMID   12138109.
  17. 1 2 Nappier, Terri (March 3, 2017). "The father of the microbiome". The Source. Retrieved August 2, 2025.
  18. 1 2 Lodge, Jennifer K.; Jackson-Machelski, Emily; Devadas, Balekudru; Zupec, Mark E.; Getman, Daniel P.; Kishore, Nandini; Freeman, Sandra K.; McWherter, Charles A.; Sikorski, James A.; Gordon, Jeffrey I. (February 1997). "N-myristoylation of Arf proteins in Candida albicans: an in vivo assay for evaluating antifungal inhibitors of myristoyl-CoA: protein N-myristoyltransferase". Microbiology. 143 ( Pt 2) (2): 357–366. doi: 10.1099/00221287-143-2-357 . ISSN   1350-0872. PMID   9043113.
  19. ↑ Hermiston, M. L.; Wong, M. H.; Gordon, J. I. (April 15, 1996). "Forced expression of E-cadherin in the mouse intestinal epithelium slows cell migration and provides evidence for nonautonomous regulation of cell fate in a self-renewing system". Genes & Development. 10 (8): 985–996. doi: 10.1101/gad.10.8.985 . ISSN   0890-9369. PMID   8608945.
  20. ↑ Bry, L.; Falk, P. G.; Midtvedt, T.; Gordon, J. I. (September 6, 1996). "A model of host-microbial interactions in an open mammalian ecosystem". Science. 273 (5280): 1380–1383. Bibcode:1996Sci...273.1380B. doi:10.1126/science.273.5280.1380. ISSN   0036-8075. PMID   8703071.
  21. ↑ Hooper, L. V.; Xu, J.; Falk, P. G.; Midtvedt, T.; Gordon, J. I. (August 17, 1999). "A molecular sensor that allows a gut commensal to control its nutrient foundation in a competitive ecosystem". Proceedings of the National Academy of Sciences of the United States of America. 96 (17): 9833–9838. Bibcode:1999PNAS...96.9833H. doi: 10.1073/pnas.96.17.9833 . ISSN   0027-8424. PMC   22296 . PMID   10449780.
  22. ↑ Hooper, L. V.; Wong, M. H.; Thelin, A.; Hansson, L.; Falk, P. G.; Gordon, J. I. (February 2, 2001). "Molecular analysis of commensal host-microbial relationships in the intestine". Science. 291 (5505): 881–884. Bibcode:2001Sci...291..881H. doi:10.1126/science.291.5505.881. ISSN   0036-8075. PMID   11157169.
  23. ↑ Xu, Jian; Bjursell, Magnus K.; Himrod, Jason; Deng, Su; Carmichael, Lynn K.; Chiang, Herbert C.; Hooper, Lora V.; Gordon, Jeffrey I. (March 28, 2003). "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis". Science. 299 (5615): 2074–2076. Bibcode:2003Sci...299.2074X. doi:10.1126/science.1080029. ISSN   1095-9203. PMID   12663928.
  24. ↑ Sonnenburg, Justin L.; Xu, Jian; Leip, Douglas D.; Chen, Chien-Huan; Westover, Benjamin P.; Weatherford, Jeremy; Buhler, Jeremy D.; Gordon, Jeffrey I. (March 25, 2005). "Glycan foraging in vivo by an intestine-adapted bacterial symbiont". Science. 307 (5717): 1955–1959. Bibcode:2005Sci...307.1955S. doi:10.1126/science.1109051. ISSN   1095-9203. PMID   15790854.
  25. ↑ Gordon JI, Ley RE, Wilson RK, Mardis E, Xu J, Fraser CM, & Relman DA. (2005). Extending Our View of Self: the Human Gut Microbiome Initiative (HGMI) [White paper]. National Human Genome Research Institute. https://www.genome.gov/Pages/Research/Sequencing/SeqProposals/HGMISeq.pdf
  26. ↑ Ley, Ruth E.; Bäckhed, Fredrik; Turnbaugh, Peter; Lozupone, Catherine A.; Knight, Robin D.; Gordon, Jeffrey I. (August 2, 2005). "Obesity alters gut microbial ecology". Proceedings of the National Academy of Sciences of the United States of America. 102 (31): 11070–11075. Bibcode:2005PNAS..10211070L. doi: 10.1073/pnas.0504978102 . ISSN   0027-8424. PMC   1176910 . PMID   16033867.
  27. ↑ Turnbaugh, Peter J.; Ley, Ruth E.; Mahowald, Michael A.; Magrini, Vincent; Mardis, Elaine R.; Gordon, Jeffrey I. (December 21, 2006). "An obesity-associated gut microbiome with increased capacity for energy harvest". Nature. 444 (7122): 1027–1031. Bibcode:2006Natur.444.1027T. doi:10.1038/nature05414. ISSN   1476-4687. PMID   17183312.
  28. ↑ Ley, Ruth E.; Turnbaugh, Peter J.; Klein, Samuel; Gordon, Jeffrey I. (December 21, 2006). "Microbial ecology: human gut microbes associated with obesity". Nature. 444 (7122): 1022–1023. Bibcode:2006Natur.444.1022L. doi:10.1038/4441022a. ISSN   1476-4687. PMID   17183309.
  29. ↑ Turnbaugh, Peter J.; Hamady, Micah; Yatsunenko, Tanya; Cantarel, Brandi L.; Duncan, Alexis; Ley, Ruth E.; Sogin, Mitchell L.; Jones, William J.; Roe, Bruce A.; Affourtit, Jason P.; Egholm, Michael; Henrissat, Bernard; Heath, Andrew C.; Knight, Rob; Gordon, Jeffrey I. (January 22, 2009). "A core gut microbiome in obese and lean twins". Nature. 457 (7228): 480–484. Bibcode:2009Natur.457..480T. doi:10.1038/nature07540. ISSN   1476-4687. PMC   2677729 . PMID   19043404.
  30. ↑ Faith, Jeremiah J.; McNulty, Nathan P.; Rey, Federico E.; Gordon, Jeffrey I. (July 1, 2011). "Predicting a human gut microbiota's response to diet in gnotobiotic mice". Science. 333 (6038): 101–104. Bibcode:2011Sci...333..101F. doi:10.1126/science.1206025. ISSN   1095-9203. PMC   3303606 . PMID   21596954.
  31. ↑ Ridaura, Vanessa K.; Faith, Jeremiah J.; Rey, Federico E.; Cheng, Jiye; Duncan, Alexis E.; Kau, Andrew L.; Griffin, Nicholas W.; Lombard, Vincent; Henrissat, Bernard; Bain, James R.; Muehlbauer, Michael J.; Ilkayeva, Olga; Semenkovich, Clay F.; Funai, Katsuhiko; Hayashi, David K. (September 6, 2013). "Gut microbiota from twins discordant for obesity modulate metabolism in mice". Science. 341 (6150): 1241214. doi:10.1126/science.1241214. ISSN   1095-9203. PMC   3829625 . PMID   24009397.{{cite journal}}: CS1 maint: article number as page number (link)
  32. ↑ Patnode, Michael L.; Beller, Zachary W.; Han, Nathan D.; Cheng, Jiye; Peters, Samantha L.; Terrapon, Nicolas; Henrissat, Bernard; Le Gall, Sophie; Saulnier, Luc; Hayashi, David K.; Meynier, Alexandra; Vinoy, Sophie; Giannone, Richard J.; Hettich, Robert L.; Gordon, Jeffrey I. (September 19, 2019). "Interspecies Competition Impacts Targeted Manipulation of Human Gut Bacteria by Fiber-Derived Glycans". Cell. 179 (1): 59–73.e13. doi:10.1016/j.cell.2019.08.011. ISSN   1097-4172. PMC   6760872 . PMID   31539500.
  33. ↑ Delannoy-Bruno, Omar; Desai, Chandani; Raman, Arjun S.; Chen, Robert Y.; Hibberd, Matthew C.; Cheng, Jiye; Han, Nathan; Castillo, Juan J.; Couture, Garret; Lebrilla, Carlito B.; Barve, Ruteja A.; Lombard, Vincent; Henrissat, Bernard; Leyn, Semen A.; Rodionov, Dmitry A. (July 2021). "Evaluating microbiome-directed fibre snacks in gnotobiotic mice and humans". Nature. 595 (7865): 91–95. Bibcode:2021Natur.595...91D. doi:10.1038/s41586-021-03671-4. ISSN   1476-4687. PMC   8324079 . PMID   34163075.
  34. ↑ Delannoy-Bruno, Omar; Desai, Chandani; Castillo, Juan J.; Couture, Garret; Barve, Ruteja A.; Lombard, Vincent; Henrissat, Bernard; Cheng, Jiye; Han, Nathan; Hayashi, David K.; Meynier, Alexandra; Vinoy, Sophie; Lebrilla, Carlito B.; Marion, Stacey; Heath, Andrew C. (May 17, 2022). "An approach for evaluating the effects of dietary fiber polysaccharides on the human gut microbiome and plasma proteome". Proceedings of the National Academy of Sciences of the United States of America. 119 (20): e2123411119. Bibcode:2022PNAS..11923411D. doi: 10.1073/pnas.2123411119 . ISSN   1091-6490. PMC   9171781 . PMID   35533274.{{cite journal}}: CS1 maint: article number as page number (link)
  35. ↑ "Research Abstract". Gordon Lab at WashU Medicine. September 17, 2024. Retrieved September 15, 2025.
  36. ↑ Yatsunenko, Tanya; Rey, Federico E.; Manary, Mark J.; Trehan, Indi; Dominguez-Bello, Maria Gloria; Contreras, Monica; Magris, Magda; Hidalgo, Glida; Baldassano, Robert N.; Anokhin, Andrey P.; Heath, Andrew C.; Warner, Barbara; Reeder, Jens; Kuczynski, Justin; Gordon, Jeffrey I.; et al. (2012). "Human gut microbiome viewed across age and geography". Nature. 486 (7402): 222–227. doi:10.1038/nature11053. ISSN   1476-4687.
  37. ↑ Strait, Julia Evangelou (April 19, 2024). "International trials underway for childhood malnutrition therapy developed at WashU". WashU Medicine. Retrieved September 15, 2025.
  38. ↑ Subramanian, Sathish; Huq, Sayeeda; Yatsunenko, Tanya; Haque, Rashidul; Mahfuz, Mustafa; Alam, Mohammed A.; Benezra, Amber; DeStefano, Joseph; Meier, Martin F.; Muegge, Brian D.; Barratt, Michael J.; VanArendonk, Laura G.; Zhang, Qunyuan; Province, Michael A.; Petri Jr, William A.; et al. (2014). "Persistent gut microbiota immaturity in malnourished Bangladeshi children". Nature. 510 (7505): 417–421. doi:10.1038/nature13421. ISSN   1476-4687.
  39. ↑ Raman, Arjun S.; Gehrig, Jeanette L.; Venkatesh, Siddarth; Chang, Hao-Wei; Hibberd, Matthew C.; Subramanian, Sathish; Kang, Gagandeep; Bessong, Pascal O.; Lima, Aldo A.M.; Kosek, Margaret N.; Petri, William A.; Rodionov, Dmitry A.; Arzamasov, Aleksandr A.; Leyn, Semen A.; Osterman, Andrei L.; et al. (July 12, 2019). "A sparse covarying unit that describes healthy and impaired human gut microbiota development". Science. 365 (6449): eaau4735. doi:10.1126/science.aau4735. PMC   6683326 . PMID   31296739.{{cite journal}}: CS1 maint: article number as page number (link)
  40. ↑ Smith, Michelle I.; Yatsunenko, Tanya; Manary, Mark J.; Trehan, Indi; Mkakosya, Rajhab; Cheng, Jiye; Kau, Andrew L.; Rich, Stephen S.; Concannon, Patrick; Mychaleckyj, Josyf C.; Liu, Jie; Houpt, Eric; Li, Jia V.; Holmes, Elaine; Nicholson, Jeremy; et al. (2013). "Gut Microbiomes of Malawian Twin Pairs Discordant for Kwashiorkor". Science. 339 (6119): 548–554. doi:10.1126/science.1229000. PMC   3667500 . PMID   23363771.
  41. ↑ Blanton, Laura V.; Charbonneau, Mark R.; Salih, Tarek; Barratt, Michael J.; Venkatesh, Siddarth; Ilkaveya, Olga; Subramanian, Sathish; Manary, Mark J.; Trehan, Indi; Jorgensen, Josh M.; Fan, Yue-mei; Henrissat, Bernard; Leyn, Semen A.; Rodionov, Dmitry A.; Osterman, Andrei L.; et al. (February 19, 2016). "Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children". Science. 351 (6275): aad3311. doi:10.1126/science.aad3311. PMC   4787260 . PMID   26912898.{{cite journal}}: CS1 maint: article number as page number (link)
  42. ↑ Subramanian, Sathish; Huq, Sayeeda; Yatsunenko, Tanya; Haque, Rashidul; Mahfuz, Mustafa; Alam, Mohammed A.; Benezra, Amber; DeStefano, Joseph; Meier, Martin F.; Muegge, Brian D.; Barratt, Michael J.; VanArendonk, Laura G.; Zhang, Qunyuan; Province, Michael A.; Petri Jr, William A.; et al. (2014). "Persistent gut microbiota immaturity in malnourished Bangladeshi children". Nature. 510 (7505): 417–421. doi:10.1038/nature13421. ISSN   1476-4687.
  43. ↑ Raman, Arjun S.; Gehrig, Jeanette L.; Venkatesh, Siddarth; Chang, Hao-Wei; Hibberd, Matthew C.; Subramanian, Sathish; Kang, Gagandeep; Bessong, Pascal O.; Lima, Aldo A.M.; Kosek, Margaret N.; Petri, William A.; Rodionov, Dmitry A.; Arzamasov, Aleksandr A.; Leyn, Semen A.; Osterman, Andrei L.; et al. (July 12, 2019). "A sparse covarying unit that describes healthy and impaired human gut microbiota development". Science. 365 (6449): eaau4735. doi:10.1126/science.aau4735. PMC   6683326 . PMID   31296739.{{cite journal}}: CS1 maint: article number as page number (link)
  44. ↑ Smith, Michelle I.; Yatsunenko, Tanya; Manary, Mark J.; Trehan, Indi; Mkakosya, Rajhab; Cheng, Jiye; Kau, Andrew L.; Rich, Stephen S.; Concannon, Patrick; Mychaleckyj, Josyf C.; Liu, Jie; Houpt, Eric; Li, Jia V.; Holmes, Elaine; Nicholson, Jeremy; et al. (2013). "Gut Microbiomes of Malawian Twin Pairs Discordant for Kwashiorkor". Science. 339 (6119): 548–554. doi:10.1126/science.1229000. PMC   3667500 . PMID   23363771.
  45. ↑ Blanton, Laura V.; Charbonneau, Mark R.; Salih, Tarek; Barratt, Michael J.; Venkatesh, Siddarth; Ilkaveya, Olga; Subramanian, Sathish; Manary, Mark J.; Trehan, Indi; Jorgensen, Josh M.; Fan, Yue-mei; Henrissat, Bernard; Leyn, Semen A.; Rodionov, Dmitry A.; Osterman, Andrei L.; et al. (February 19, 2016). "Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children". Science. 351 (6275): aad3311. doi:10.1126/science.aad3311. PMC   4787260 . PMID   26912898.{{cite journal}}: CS1 maint: article number as page number (link)
  46. ↑ Blanton, Laura V.; Charbonneau, Mark R.; Salih, Tarek; Barratt, Michael J.; Venkatesh, Siddarth; Ilkaveya, Olga; Subramanian, Sathish; Manary, Mark J.; Trehan, Indi; Jorgensen, Josh M.; Fan, Yue-mei; Henrissat, Bernard; Leyn, Semen A.; Rodionov, Dmitry A.; Osterman, Andrei L.; et al. (February 19, 2016). "Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children". Science. 351 (6275): aad3311. doi:10.1126/science.aad3311. PMC   4787260 . PMID   26912898.{{cite journal}}: CS1 maint: article number as page number (link)
  47. ↑ Blanton, Laura V.; Charbonneau, Mark R.; Salih, Tarek; Barratt, Michael J.; Venkatesh, Siddarth; Ilkaveya, Olga; Subramanian, Sathish; Manary, Mark J.; Trehan, Indi; Jorgensen, Josh M.; Fan, Yue-mei; Henrissat, Bernard; Leyn, Semen A.; Rodionov, Dmitry A.; Osterman, Andrei L.; et al. (February 19, 2016). "Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children". Science. 351 (6275): aad3311. doi:10.1126/science.aad3311. PMC   4787260 . PMID   26912898.{{cite journal}}: CS1 maint: article number as page number (link)
  48. ↑ Planer, Joseph D.; Peng, Yangqing; Kau, Andrew L.; Blanton, Laura V.; Ndao, I. Malick; Tarr, Phillip I.; Warner, Barbara B.; Gordon, Jeffrey I. (2016). "Development of the gut microbiota and mucosal IgA responses in twins and gnotobiotic mice". Nature. 534 (7606): 263–266. doi:10.1038/nature17940. ISSN   1476-4687.
  49. ↑ Hibberd, Matthew C.; Webber, Daniel M.; Rodionov, Dmitry A.; Henrissat, Suzanne; Chen, Robert Y.; Zhou, Cyrus; Lynn, Hannah M.; Wang, Yi; Chang, Hao-Wei; Lee, Evan M.; Lelwala-Guruge, Janaki; Kazanov, Marat D.; Arzamasov, Aleksandr A.; Leyn, Semen A.; Lombard, Vincent; et al. (2024). "Bioactive glycans in a microbiome-directed food for children with malnutrition". Nature. 625 (7993): 157–165. doi:10.1038/s41586-023-06838-3. ISSN   1476-4687.
  50. ↑ Chang, Hao-Wei; Lee, Evan M.; Wang, Yi; Zhou, Cyrus; Pruss, Kali M.; Henrissat, Suzanne; Chen, Robert Y.; Kao, Clara; Hibberd, Matthew C.; Lynn, Hannah M.; Webber, Daniel M.; Crane, Marie; Cheng, Jiye; Rodionov, Dmitry A.; Arzamasov, Aleksandr A.; et al. (2024). "Prevotella copri and microbiota members mediate the beneficial effects of a therapeutic food for malnutrition". Nature Microbiology. 9 (4): 922–937. doi:10.1038/s41564-024-01628-7. ISSN   2058-5276.
  51. ↑ Cheng, Jiye; Venkatesh, Siddarth; Ke, Ke; Barratt, Michael J.; Gordon, Jeffrey I. (October 25, 2024). "A human gut Faecalibacterium prausnitzii fatty acid amide hydrolase". Science. 386 (6720): eado6828. doi:10.1126/science.ado6828. PMC   11572954 . PMID   39446943.{{cite journal}}: CS1 maint: article number as page number (link)
  52. ↑ Hibberd, Matthew C.; Webber, Daniel M.; Rodionov, Dmitry A.; Henrissat, Suzanne; Chen, Robert Y.; Zhou, Cyrus; Lynn, Hannah M.; Wang, Yi; Chang, Hao-Wei; Lee, Evan M.; Lelwala-Guruge, Janaki; Kazanov, Marat D.; Arzamasov, Aleksandr A.; Leyn, Semen A.; Lombard, Vincent; et al. (2024). "Bioactive glycans in a microbiome-directed food for children with malnutrition". Nature. 625 (7993): 157–165. doi:10.1038/s41586-023-06838-3. ISSN   1476-4687.
  53. ↑ Chang, Hao-Wei; Lee, Evan M.; Wang, Yi; Zhou, Cyrus; Pruss, Kali M.; Henrissat, Suzanne; Chen, Robert Y.; Kao, Clara; Hibberd, Matthew C.; Lynn, Hannah M.; Webber, Daniel M.; Crane, Marie; Cheng, Jiye; Rodionov, Dmitry A.; Arzamasov, Aleksandr A.; et al. (2024). "Prevotella copri and microbiota members mediate the beneficial effects of a therapeutic food for malnutrition". Nature Microbiology. 9 (4): 922–937. doi:10.1038/s41564-024-01628-7. ISSN   2058-5276.
  54. ↑ Strait, Julia Evangelou (April 7, 2021). "For malnourished children, a new type of microbiome-directed food boosts growth". WashU Medicine. Retrieved September 15, 2025.
  55. ↑ Cheng, Jiye; Venkatesh, Siddarth; Ke, Ke; Barratt, Michael J.; Gordon, Jeffrey I. (October 25, 2024). "A human gut Faecalibacterium prausnitzii fatty acid amide hydrolase". Science. 386 (6720). doi:10.1126/science.ado6828. PMC   11572954 . PMID   39446943.
  56. ↑ Hibberd, Matthew C.; Webber, Daniel M.; Rodionov, Dmitry A.; Henrissat, Suzanne; Chen, Robert Y.; Zhou, Cyrus; Lynn, Hannah M.; Wang, Yi; Chang, Hao-Wei; Lee, Evan M.; Lelwala-Guruge, Janaki; Kazanov, Marat D.; Arzamasov, Aleksandr A.; Leyn, Semen A.; Lombard, Vincent; et al. (2024). "Bioactive glycans in a microbiome-directed food for children with malnutrition". Nature. 625 (7993): 157–165. doi:10.1038/s41586-023-06838-3. ISSN   1476-4687.
  57. ↑ Strait, Julia Evangelou (April 7, 2021). "For malnourished children, a new type of microbiome-directed food boosts growth". WashU Medicine. Retrieved September 15, 2025.
  58. ↑ Hibberd, Matthew C.; Webber, Daniel M.; Rodionov, Dmitry A.; Henrissat, Suzanne; Chen, Robert Y.; Zhou, Cyrus; Lynn, Hannah M.; Wang, Yi; Chang, Hao-Wei; Lee, Evan M.; Lelwala-Guruge, Janaki; Kazanov, Marat D.; Arzamasov, Aleksandr A.; Leyn, Semen A.; Lombard, Vincent; et al. (2024). "Bioactive glycans in a microbiome-directed food for children with malnutrition". Nature. 625 (7993): 157–165. doi:10.1038/s41586-023-06838-3. ISSN   1476-4687.
  59. ↑ Strait, Julia Evangelou (December 13, 2023). "Gut bacteria of malnourished children benefit from key elements in therapeutic food". WashU Medicine. Retrieved September 15, 2025.
  60. ↑ Strait, Julia Evangelou (April 19, 2024). "International trials underway for childhood malnutrition therapy developed at WashU". WashU Medicine. Retrieved September 15, 2025.
  61. ↑ Barratt, Michael J.; Nuzhat, Sharika; Ahsan, Kazi; Frese, Steven A.; Arzamasov, Aleksandr A.; Sarker, Shafiqul Alam; Islam, M. Munirul; Palit, Parag; Islam, Md Ridwan; Hibberd, Matthew C.; Nakshatri, Swetha; Cowardin, Carrie A.; Guruge, Janaki L.; Byrne, Alexandra E.; Venkatesh, Siddarth; et al. (2022). "Bifidobacterium infantis treatment promotes weight gain in Bangladeshi infants with severe acute malnutrition". Science Translational Medicine. 14 (640): eabk1107. doi:10.1126/scitranslmed.abk1107. PMC   9516695 . PMID   35417188.{{cite journal}}: CS1 maint: article number as page number (link)
  62. ↑ "Duodenal Microbiota in Stunted Undernourished Children with Enteropathy". New England Journal of Medicine. 384 (18): 1777–1778. May 5, 2021. doi:10.1056/NEJMc2030388. ISSN   0028-4793.
  63. ↑ Strait, Julia Evangelou (April 19, 2024). "International trials underway for childhood malnutrition therapy developed at WashU". WashU Medicine. Retrieved September 15, 2025.
  64. ↑ Strait, Julia Evangelou (April 19, 2024). "International trials underway for childhood malnutrition therapy developed at WashU". WashU Medicine. Retrieved September 15, 2025.
  65. ↑ "The 2017 Award Winners". Institut Pasteur (in French). December 4, 2017. Retrieved February 21, 2025.
  66. 1 2 "Gordon CV". Lab of Jeffrey I. Gordon. June 26, 2020. Retrieved February 23, 2021.
  67. ↑ "Jeffrey I. Gordon". www.balzan.org. Retrieved April 13, 2022.
  68. ↑ "Association of American Physicians". aap-online.org. Retrieved February 21, 2025.
  69. ↑ Lewis, Talia (September 15, 2022). "Jeffrey Gordon Receives Inaugural Hamburg Award for Pioneering Contributions to Microbiome Research - National Academy of Medicine". National Academy of Medicine. Archived from the original on September 27, 2023. Retrieved February 21, 2025.
  70. ↑ "Microbiome researcher Jeffrey Gordon receives the 2022 Dr. Paul Janssen Award for biomedical research". JNJ.com. February 9, 2023. Retrieved February 21, 2025.
  71. ↑ Princess of Asturias Awards 2023
  72. ↑ Albany Medical Center Prize 2023
  73. ↑ Nemmers Prize in Medical Science 2024
  74. ↑ Duran, Karissa (September 18, 2024). "Scripps Oceanography Selects Microbiome Researcher Jeffrey I. Gordon as 2024 Nierenberg Prize Recipient | Scripps Institution of Oceanography". scripps.ucsd.edu. Retrieved February 5, 2025.
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