John Michael Ramsey

Last updated
John Michael Ramsey
Born
Mansfield, Ohio
CitizenshipUnited States of America
Alma mater Bowling Green State University (B.S. 1974)
Indiana University (Ph.D. 1979)
Scientific career
Fields Microfabricated chemical instrumentation, microfluidics, nanofluidics
Institutions University of North Carolina at Chapel Hill, Department of Chemistry
Thesis New Approaches for the Measurement of Subnanosecond Chemical Phenomena (1979)
Doctoral advisor Dr. Gary M. Hieftje
Website www.chem.unc.edu/people/faculty/ramsey/group/index.html

John Michael Ramsey is an American analytical chemist at the University of North Carolina at Chapel Hill. He currently holds the position of Minnie N. Goldby Distinguished Professor of Chemistry. [1] His current research with the university focuses on microscale and nanoscale devices such as microchip electrospray, microscale Ion trap mass spectrometers, and microfluidic point of care devices. [2] He is ranked #2 in the "Giants of Nano" field on The Analytical Scientist Power List. [3]

Contents

Career

Early research

Michael Ramsey attended Bowling Green State University for his undergraduate studies where he obtained his Bachelor of Science in Chemistry with dual minors in Physics and Mathematics in June 1974. [4]

He then went on to obtain his Doctor of Philosophy in Analytical chemistry from Indiana University Bloomington in January 1979. Dr. Ramsey conducted his research under the direction of Gary M. Hieftje from 1974-1979 culminating in his published dissertation "New Approaches for the Measurement of Subnanosecond Chemical Phenomena" . [4]

Current research

The Ramsey Group at the University of Chapel Hill is interested in utilizing micro- and nano fabrication strategies to create devices that facilitate people's ability to gather chemical and biochemical information. Their motivations for fabricating devices include clinical diagnostics, high-throughput biochemical experimentation, understanding of transport mechanisms in nanoscale-confined spaces, and development of portable mass spectrometers operating at high-pressures (>1 Torr).

Applications for the devices that they develop include drug discovery, health care, environmental monitoring, chemical process control, and high-throughput laboratory analysis and basic research.

The four main areas of active research in the Ramsey group include:

  1. Microchip electrospray
  2. Microfluidic point of care
  3. Microscale Ion Trap MS
  4. Nanofluidics

Industry

He is a founding scientist and current director of 908 Devices incorporated, [5] a company which focuses on building handheld mass spectrometry devices for applications in laboratory analysis, safety and security, as well as for use in the life sciences. [6] In 2017 908 Devices Inc. received the Federal Laboratory Consortium Excellence in Technology Transfer Award. [4] The company is known for several products, including the zipchip ™ separations platform for quick and high quality separation and mass spectrometry analysis of biological samples and the M908 ™ handheld High Pressure Mass Spectrometry tool for analysis of chemical warfare agents. [6] Dr. Ramsey is also a founding scientist and former scientific advisory board member of Caliper Technologies incorporated, later renamed Caliper Life Sciences, a company that commercializes microfluidics and lab-on-a-chip technologies. [4] Caliper Life Sciences was acquired by PerkinElmer in 2011 for $650M. [6]

Between 1979 and 2004, Ramsey worked as a Eugene P. Wigner Fellow, research associate, and eventually a group leader for Oak Ridge National Laboratory. [4] [7]

Awards/memberships

Awards that Ramsey has received include the Ralph N. Adams Award in Bioanalytical Chemistry (2013), [8] the CASSS Award for Outstanding Achievements in Separation Science (2012), [9] the American Chemical Society Award in Chromatography (2007), [10] the Pittsburgh Analytical Chemistry Award (2006), [11] the ACS Division of Analytical Chemistry Award in Chemical Instrumentation (2003), [12] [13] the Battelle Distinguished Inventor Award (2003), [13] and the Frederick Conference Capillary Electrophoresis Award (2000). [4] [14]

Ramsey holds professional memberships with National Academy of Engineering, the American Chemical Society, and the Analytical Division of the American Chemical Society. [4]

He has 108 issues patents, 2 allowed patents, and 20 pending patents. [4]

Related Research Articles

<span class="mw-page-title-main">Richard Zare</span> American chemist

Richard Neil Zare is the Marguerite Blake Wilbur Professor in Natural Science and a Professor of Chemistry at Stanford University. Throughout his career, Zare has made a considerable impact in physical chemistry and analytical chemistry, particularly through the development of laser-induced fluorescence (LIF) and the study of chemical reactions at the molecular and nanoscale level. LIF is an extremely sensitive technique with applications ranging from analytical chemistry and molecular biology to astrophysics. One of its applications was the sequencing of the human genome.

<span class="mw-page-title-main">Matthias Mann</span>

Matthias Mann is a scientist in the area of mass spectrometry and proteomics.

Robert Graham Cooks is the Henry Bohn Hass Distinguished Professor of Chemistry in the Aston Laboratories for Mass Spectrometry at Purdue University. He is an ISI Highly Cited Chemist, with over 1,000 publications and an H-index of 144.

<span class="mw-page-title-main">Christie G. Enke</span> American chemist

Christie G. Enke is a United States academic chemist who made pioneering contributions to the field of analytical chemistry.

Scott A. McLuckey is an American chemist, the John A. Leighty Distinguished Professor of Chemistry at Purdue University. His research concerns the formation of ionized versions of large biomolecules, mass spectrometry of these ions, and ion-ion reactions.

Gary J Van Berkel, born in 1959, is the research scientist who led the Organic and Biological Mass Spectrometry Group at Oak Ridge National Laboratory until his retirement from there in 2018. He is currently owner and CSO of Van Berkel Ventures, LLC, an analytical measurement science, innovation, research, consulting and writing firm in Oak Ridge, TN.

<span class="mw-page-title-main">Matrix-assisted laser desorption electrospray ionization</span>

Matrix-assisted laser desorption electrospray ionization (MALDESI) was first introduced in 2006 as a novel ambient ionization technique which combines the benefits of electrospray ionization (ESI) and matrix-assisted laser desorption/ionization (MALDI). An infrared (IR) or ultraviolet (UV) laser can be utilized in MALDESI to resonantly excite an endogenous or exogenous matrix. The term ‘matrix’ refers to any molecule that is present in large excess and absorbs the energy of the laser, thus facilitating desorption of analyte molecules. The original MALDESI design was implemented using common organic matrices, similar to those used in MALDI, along with a UV laser. The current MALDESI source employs endogenous water or a thin layer of exogenously deposited ice as the energy-absorbing matrix where O-H symmetric and asymmetric stretching bonds are resonantly excited by a mid-IR laser.

<span class="mw-page-title-main">Desorption atmospheric pressure photoionization</span>

Desorption atmospheric pressure photoionization (DAPPI) is an ambient ionization technique for mass spectrometry that uses hot solvent vapor for desorption in conjunction with photoionization. Ambient Ionization techniques allow for direct analysis of samples without pretreatment. The direct analysis technique, such as DAPPI, eliminates the extraction steps seen in most nontraditional samples. DAPPI can be used to analyze bulkier samples, such as, tablets, powders, resins, plants, and tissues. The first step of this technique utilizes a jet of hot solvent vapor. The hot jet thermally desorbs the sample from a surface. The vaporized sample is then ionized by the vacuum ultraviolet light and consequently sampled into a mass spectrometer. DAPPI can detect a range of both polar and non-polar compounds, but is most sensitive when analyzing neutral or non-polar compounds. This technique also offers a selective and soft ionization for highly conjugated compounds.

<span class="mw-page-title-main">Capillary electrophoresis–mass spectrometry</span>

Capillary electrophoresis–mass spectrometry (CE–MS) is an analytical chemistry technique formed by the combination of the liquid separation process of capillary electrophoresis with mass spectrometry. CE–MS combines advantages of both CE and MS to provide high separation efficiency and molecular mass information in a single analysis. It has high resolving power and sensitivity, requires minimal volume and can analyze at high speed. Ions are typically formed by electrospray ionization, but they can also be formed by matrix-assisted laser desorption/ionization or other ionization techniques. It has applications in basic research in proteomics and quantitative analysis of biomolecules as well as in clinical medicine. Since its introduction in 1987, new developments and applications have made CE-MS a powerful separation and identification technique. Use of CE–MS has increased for protein and peptides analysis and other biomolecules. However, the development of online CE–MS is not without challenges. Understanding of CE, the interface setup, ionization technique and mass detection system is important to tackle problems while coupling capillary electrophoresis to mass spectrometry.

<span class="mw-page-title-main">Laser ablation electrospray ionization</span>

Laser ablation electrospray ionization (LAESI) is an ambient ionization method for mass spectrometry that combines laser ablation from a mid-infrared (mid-IR) laser with a secondary electrospray ionization (ESI) process. The mid-IR laser is used to generate gas phase particles which are then ionized through interactions with charged droplets from the ESI source. LAESI was developed in Professor Akos Vertes lab by Dr. Peter Nemes in 2007 and it was marketed commercially by Protea Biosciences, Inc until 2017. Fiber-LAESI for single-cell analysis approach was developed by Dr. Bindesh Shrestha in Professor Vertes lab in 2009. LAESI is a novel ionization source for mass spectrometry (MS) that has been used to perform MS imaging of plants, tissues, cell pellets, and even single cells. In addition, LAESI has been used to analyze historic documents and untreated biofluids such as urine and blood. The technique of LAESI is performed at atmospheric pressure and therefore overcomes many of the obstacles of traditional MS techniques, including extensive and invasive sample preparation steps and the use of high vacuum. Because molecules and aerosols are ionized by interacting with an electrospray plume, LAESI's ionization mechanism is similar to SESI and EESI techniques.

<span class="mw-page-title-main">Renato Zenobi</span> Swiss chemist

Renato Zenobi is a Swiss chemist. He is Professor of Chemistry at ETH Zurich. Throughout his career, Zenobi has contributed to the field of analytical chemistry.

Richard Dale Smith is a chemist and a Battelle Fellow and chief scientist within the biological sciences division, as well as the director of proteomics research at the Pacific Northwest National Laboratory (PNNL). Smith is also director of the NIH Proteomics Research Resource for Integrative Biology, an adjunct faculty member in the chemistry departments at Washington State University and the University of Utah, and an affiliate faculty member at the University of Idaho and the Department of Molecular Microbiology & Immunology, Oregon Health & Science University. He is the author or co-author of approximately 1100 peer-reviewed publications and has been awarded 70 US patents.

<span class="mw-page-title-main">Catherine Clarke Fenselau</span> American scientist

Catherine Clarke Fenselau is an American scientist who was the first trained mass spectrometrist on the faculty of an American medical school; she joined Johns Hopkins School of Medicine in 1968. She specializes in biomedical applications of mass spectrometry. She has been recognized as an outstanding scientist in the field of bioanalytical chemistry because of her work using mass spectrometry to study biomolecules.

Cynthia Larive is an American scientist and academic administrator serving as the chancellor of University of California, Santa Cruz. Larive's research focuses on nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry. She was previously a professor of chemistry and provost and executive vice chancellor at the University of California, Riverside. She is a fellow of AAAS, IUPAC and ACS, associate editor for the ACS journal Analytical Chemistry and editor of the Analytical Sciences Digital Library.

Peter Nemes is a Hungarian-American chemist, who is active in the fields of bioanalytical chemistry, mass spectrometry, cell/developmental biology, neuroscience, and biochemistry.

Vicki Wysocki is an American scientist. She is a professor and an Ohio Eminent Scholar at Ohio State University, and also the director of the Campus Chemical Instrument Center.

Robert Travis Kennedy is an American chemist specializing in bioanalytical chemistry including liquid chromatography, capillary electrophoresis, and microfluidics. He is currently the Hobart H. Willard Distinguished University Professor of Chemistry and the chair of the department of chemistry at the University of Michigan. He holds joint appointments with the Department of Pharmacology and Department Macromolecular Science and Engineering. Kennedy is an Associate Editor of Analytical Chemistry.

Abraham Badu-Tawiah is a Ghanaian scientist who is an Associate Professor of Chemistry at the Ohio State University. His research considers the development of mass spectrometry for the detection of disease. In 2017 he was awarded the American Chemical Society Arthur F. Findeis prize and in 2020 a Sloan Research Fellowship.

<span class="mw-page-title-main">Julia Laskin</span> Russian–American Chemist

Julia Laskin is the William F. and Patty J. Miller Professor of Analytical Chemistry at Purdue University. Her research is focused on the fundamental understanding of ion-surface collisions, understanding of phenomena underlying chemical analysis of large molecules in complex heterogeneous environments, and the development of new instrumentation and methods in preparative and imaging mass spectrometry.

Erin Shammel Baker is an American bioanalytical chemist specializing in developing ion mobility-mass spectrometry hybrid instruments for biological and environmental applications. Baker is an expert in the research of perfluoroalkyl and polyfluoroalkyl substances analysis.

References

  1. ↑ Department of Chemistry, University of North Carolina at Chapel Hill. "John Michael Ramsey". www.chem.unc.edu. Retrieved 2018-03-20.
  2. ↑ Ramsey, Michael. "Ramsey Research Group Website". www.chem.unc.edu.
  3. ↑ "The Power List 2017". theanalyticalscientist.com. The Analytical Scientist.
  4. 1 2 3 4 5 6 7 8 Ramsey, John. "John Michael Ramsey Curriculum Vitae" (PDF).
  5. ↑ "Dr. J. Michael Ramsey - 908 Devices". 908 Devices. Retrieved 2018-04-24.
  6. 1 2 3 "About - 908 Devices". 908 Devices. Retrieved 2018-03-20.
  7. ↑ "J Ramsey | ORNL". ornl.info. Retrieved 2018-04-24.
  8. ↑ "Ralph N. Adams Award in Bioanalytical Chemistry". Adams Institute. 2012-06-26. Retrieved 2018-04-24.
  9. ↑ "CASSS Award 2012 - CASSS". www.casss.org. Retrieved 2018-04-24.
  10. ↑ "ACS Award in Chromatography - American Chemical Society". American Chemical Society. Retrieved 2018-04-24.
  11. ↑ Editors, LCGC. "The Pittsburgh Analytical Chemistry Award". www.chromatographyonline.com. Retrieved 2018-04-24.{{cite web}}: |last= has generic name (help)
  12. ↑ "Chemical Instrumentation". ACS Division of Analytical Chemistry. Archived from the original on 2017-04-24. Retrieved 2018-04-24.
  13. 1 2 "ORNL researcher earns American Chemical Society award | ORNL". www.ornl.gov. Retrieved 2018-04-24.
  14. ↑ "People: CE Award". Analytical Chemistry. 72 (21): 685 A. November 2000. doi: 10.1021/ac002974f . ISSN   0003-2700.
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.