Jordan S. Orange | |
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Academic background | |
Education | A.B. Biology, Brown University PhD, 1996, MD, 1997, Alpert Medical School |
Thesis | IL-12 and viral infections (1996) |
Academic work | |
Institutions | Columbia University Vagelos College of Physicians and Surgeons Baylor College of Medicine Perelman School of Medicine at the University of Pennsylvania |
Jordan Scott Orange is an American pediatric immunologist. Orange is credited with defining a new class of diseases known as natural killer cell deficiencies.
Orange completed his Bachelor's degree,PhD,and medical degree from Brown University and conducted his residency training at the Children's Hospital of Philadelphia (CHOP),clinical fellowship at Boston Children's Hospital,and a post-doctoral research fellowship at Harvard University. [1] While at Brown University,he discovered that natural killer cells produce cytokines to participate in defending the body against viruses. [2] His thesis,published in 1996,was titled "IL-12 and viral infections." [3]
Following his residency and fellowships,Orange accepted a faculty position at the Perelman School of Medicine at the University of Pennsylvania. [1] During his tenure,he also worked at CHOP where he focused on Wiskott–Aldrich syndrome. Orange continued his research stemming from his graduate studies and developed a novel therapy that bypasses the natural killer cell defect. As a result of his contributions to research and treatment of inherited immune deficiency diseases,Orange received the 2009 American Philosophical Society Judson Daland Prize. [2] The following year,he collaborated with German researcher Christoph Klein to perform cell imaging and analysis on children diagnosed with WAS soon after birth. They collected some of their hematopoietic stem cells and then transferred normal WAS genes into those cells and returned the cells to the children's bloodstreams. [4] Due to his studies,Orange was elected a member of the American Society for Clinical Investigation. [5]
Orange eventually left the University of Pennsylvania in 2012 to join the faculty at Baylor College of Medicine (BCM) and serve as chief of Immunology,Allergy and Rheumatology and director of the Center for Human Immunobiology at Texas Children's Hospital. [6] He remained in Houston until 2018 when he joined the faculty at Columbia University Vagelos College of Physicians and Surgeons as their chair of pediatrics and pediatrician-in-chief at Morgan Stanley Children's Hospital. [7] In his final year at BCM,Orange was the recipient of the 2018 Edith and Peter O'Donnell Award in Medicine from the Academy of Medicine,Engineering and Science of Texas. [8]
Upon joining the faculty at Columbia,Orange was elected to the National Academy of Medicine for his contributions to medical science,health care,and public health. [9] During the COVID-19 pandemic,Orange wrote an op-ed on Stat calling for adults to "put children's health first." [10]
Baylor College of Medicine (BCM) is a private,independent health sciences center in Houston,Texas within the Texas Medical Center,the world's largest medical center. BCM is composed of four academic components:the School of Medicine,the Graduate School of Biomedical Sciences;the School of Health Professions,and the National School of Tropical Medicine.
The University of Rochester Medical Center (URMC),now known as UR Medicine,is located in Rochester,New York,is one of the main campuses of the University of Rochester and comprises the university's primary medical education,research and patient care facilities.
Philippa "Pippa" Marrack, Ph.D,FRS is an English immunologist and academic,based in the United States,best known for her research and discoveries pertaining to T cells. Marrack is the Ida and Cecil Green Professor and chair of the Department of Biomedical Research at National Jewish Health and a Distinguished Professor of immunology and microbiology at the University of Colorado Denver.
Hans Dieter Ochs,is an immunologist and pediatrician. He is Professor of Pediatrics,Division of Immunology,Department of Pediatrics,University of Washington School of Medicine,Seattle.
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Frederick W. Alt is an American geneticist. He is a member of the Immunology section of the National Academy of Sciences and a Charles A. Janeway Professor of Pediatrics,and Professor of Genetics at Harvard Medical School. He is the Director of the Program in Cellular and Molecular Medicine at the Boston Children's Hospital. He is a Howard Hughes Medical Institute investigator,since 1987.
James Patrick Allison is an American immunologist and Nobel laureate who holds the position of professor and chair of immunology and executive director of immunotherapy platform at the MD Anderson Cancer Center at the University of Texas.
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Herman Nathaniel Eisen was an American immunologist and cancer researcher. He served on the faculty at New York University School of Medicine in the early 1950s,became the Chief of Dermatology at the Washington University School of Medicine in 1955,and was a founding member of the MIT Center for Cancer Research. Eisen retired and assumed professor emeritus status in 1989,but continued to be active as a researcher;he was working on a manuscript the day he died in 2014.
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