Hypericin is a naphthodianthrone, an anthraquinone derivative which, together with hyperforin, is one of the principal active constituents of Hypericum. Hypericin is believed to act as an antibiotic, antiviral and non-specific kinase inhibitor. Hypericin may inhibit the action of the enzyme dopamine β-hydroxylase, leading to increased dopamine levels, although thus possibly decreasing norepinephrine and epinephrine.
Organic & Biomolecular Chemistry is a weekly peer-reviewed scientific journal covering all aspects of organic chemistry, including organic aspects of chemical biology, medicinal chemistry, natural product chemistry, supramolecular chemistry, macromolecular chemistry, theoretical chemistry, and catalysis. It is published by the Royal Society of Chemistry. Its predecessor journals were Perkin Transactions I and Perkin Transactions II. The Executive Editor is Richard Kelly.
An enzyme inhibitor is a molecule that binds to an enzyme and blocks its activity. Enzymes are proteins that speed up chemical reactions necessary for life, in which substrate molecules are converted into products. An enzyme facilitates a specific chemical reaction by binding the substrate to its active site, a specialized area on the enzyme that accelerates the most difficult step of the reaction.
Direct thrombin inhibitors (DTIs) are a class of medication that act as anticoagulants by directly inhibiting the enzyme thrombin. Some are in clinical use, while others are undergoing clinical development. Several members of the class are expected to replace heparin and warfarin in various clinical scenarios.
Current Pharmaceutical Design is a peer-reviewed medical journal which covers issues related to pharmacology and medicinal chemistry. Each issue is devoted to a single major therapeutic area. For each issue, an executive editor is chosen who is an acknowledged authority in that field.
Phytochemistry is a peer-reviewed scientific journal covering pure and applied plant chemistry, plant biochemistry and molecular biology. It is published by Elsevier and is an official publication for the Phytochemical Society of Europe, the Phytochemical Society of North America, and the Phytochemical Society of Asia.
(S)-Canadine, also known as (S)-tetrahydroberberine and xanthopuccine, is a benzylisoquinoline alkaloid (BIA), of the protoberberine structural subgroup, and is present in many plants from the family Papaveraceae, such as Corydalis yanhusuo and C. turtschaninovii.
Talarozole was an investigational drug for the treatment of acne, psoriasis and other keratinization disorders. Development for that purpose has been discontinued. However, its effect in increasing retinoic acid is now being investigated in hand osteoarthritis.
Current Medicinal Chemistry is a peer-reviewed medical journal published by Bentham Science Publishers. The editor-in-chief is Atta-ur-Rahman, FRS. The journal covers developments in medicinal chemistry and rational drug design and publishes original research reports and review papers.
Current Topics in Medicinal Chemistry is a biweekly peer-reviewed medical journal published by Bentham Science Publishers. It includes review articles on all aspects of medicinal chemistry, including drug design. The current editor-in-chief is Jia Zhou.
Moon Hyung-In is a professor at Dong-A University in Busan, South Korea. He is a member of the Department of Medicinal Biotechnology, and he earned his PhD in the Department of Pharmacy at Sungkyunkwan University in 2001.
Combinatorial Chemistry & High Throughput Screening is a peer-reviewed scientific journal that covers combinatorial chemistry. It was established in 1998 and is published by Bentham Science Publishers. The editor-in-chief is Gerald H. Lushington. The journal has 5 sections: Combinatorial/ Medicinal Chemistry, Chemo/Bio Informatics, High Throughput Screening, Pharmacognosy, and Laboratory Automation.
Acolbifene (INN) is a nonsteroidal selective estrogen receptor modulator (SERM) which, as of 2015, is in phase III clinical trials for the treatment of breast cancer.
Mini-Reviews in Medicinal Chemistry is a monthly peer-reviewed medical journal covering all aspects of medicinal chemistry. It is published by Bentham Science Publishers and the editors-in-chief are Atta-ur-Rahman, M. Iqbal Choudhary, and George Perry.
Future Medicinal Chemistry is a peer-reviewed medical journal covering all aspects of medicinal chemistry, including drug discovery, pharmacology, in silico drug design, structural characterization techniques, ADME-Tox investigations, and science policy, economic and intellectual property issues. It was established in 2009 and is published by Future Science. The editors-in-chief are Iwao Ojima and Jonathan Baell.
Broparestrol (INN), also known as α-bromo-α,β-diphenyl-β-p-ethylphenylethylene (BDPE), is a synthetic, nonsteroidal selective estrogen receptor modulator (SERM) of the triphenylethylene group that has been used in Europe as a dermatological agent and for the treatment of breast cancer. The drug is described as slightly estrogenic and potently antiestrogenic, and inhibits mammary gland development and suppresses prolactin levels in animals. It is structurally related to clomifene and diethylstilbestrol. Broparestrol is a mixture of E- and Z- isomers, both of which are active and are similarly antiestrogenic but, unlike broparestrol, were never marketed.
Barry Victor Lloyd Potter MAE FMedSci is a British chemist, who is Professor of Medicinal & Biological Chemistry at the University of Oxford, Wellcome Trust Senior Investigator and a Fellow of University College, Oxford.
Anti-Cancer Agents in Medicinal Chemistry is a peer-reviewed academic journal covering the disciplines of medicinal chemistry and drug design relating to chemotherapeutic agents in cancer. It is published by Bentham Science Publishers and the editor-in-chief is Simone Carradori. The journal covers developments in "medicinal chemistry and rational drug design for the discovery of anti-cancer agents" and publishes original research reports and review papers.
Medicinal Chemistry Research is a peer-reviewed scientific journal of medicinal chemistry emphasizing the structure-activity relationships of biologically active compounds. It was founded in 1991 by Alfred Burger, who also founded the Journal of Medicinal Chemistry. The journal is currently edited by Longqin Hu.
