KI polyomavirus

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KI polyomavirus
Virus classification OOjs UI icon edit-ltr.svg
(unranked): Virus
Realm: Monodnaviria
Kingdom: Shotokuvirae
Phylum: Cossaviricota
Class: Papovaviricetes
Order: Sepolyvirales
Family: Polyomaviridae
Genus: Betapolyomavirus
Species:
Betapolyomavirus tertihominis
Synonyms
  • Human polyomavirus 3

KI polyomavirus (also known as KI virus, KIPyV, or Human polyomavirus 3) is a virus of the family Polyomaviridae . It was discovered in 2007 in stored samples of human respiratory secretions collected by the Karolinska Institute, after which the virus is named. [1]

Contents

Discovery

KI virus was discovered in 2007 in samples of human respiratory secretions being systematically searched as part of a program for identifying novel human viruses. It was identified by sequence homology to known human polyomaviruses BK virus and JC virus, and simian polyomavirus SV40. [1] KI virus was the third human polyomavirus described and the first to be discovered since BK and JC in 1971. [2] A very similar respiratory virus, WU virus, was also reported later in 2007. [3]

Genome

Genome structure of the WU virus. KI virus has a near-identical structure with a slightly different length of 5040 base pairs. Gaynor plospathogens 2007 WUvirusgenome.png
Genome structure of the WU virus. KI virus has a near-identical structure with a slightly different length of 5040 base pairs.

The complete genome of the KI virus has been sequenced and found to be a circular double-stranded DNA genome of 5040 base pairs containing genetic material characteristic of polyomaviruses, encoding five viral proteins: three capsid components, major capsid protein VP1, VP2, and VP3; and two additional proteins involved in replication, the large tumor antigen and small tumor antigen. [1]

Prevalence

The prevalence of KI virus as detected by the presence of its DNA in human samples is generally estimated in the 1-5% range in various locations and populations, with some indication of age-dependence. [4] The virus has been detected in the respiratory secretions of children with respiratory infections in multiple locations. [5] [6] By contrast, one 2009 study placed seroprevalence - that is, prevalence of antibodies against the virus (in this case the VP1 coat protein) - as high as 55% among a population of American adults and 56% among a population of American children. [7] Another 2009 study found around 70% seroprevalence for adults, with age patterns indicating that infants may inherit maternal antibodies against both WU and KI. [8] A 2016 study of polyomavirus seroprevalence found WU virus in 91.3% of samples from another American population. [9] Primary infection is generally believed to occur in childhood. [9]

Disease association

KI virus, like its close relative WU virus, is not known to be associated with any clinical disease despite its presence in respiratory secretions. [10] The rate of co-infection with other respiratory viruses is high, so it is difficult to assign causality to KI virus even where clinical symptoms are present. [4] Some polyomaviruses are well known as carcinogenic, including the human polyomavirus Merkel cell polyomavirus, but KI virus has also not been associated with cancer. [11] While no clear association with clinical symptoms has been identified, there is weak indication that WU and KI viruses may have pathogenic potential in immunocompromised patients. [12]

Nomenclature and classification

KI virus got its name from the Karolinska Institute, the institutional affiliation of the researchers who discovered and reported the virus. [1]

Among the human polyomaviruses, KI is most similar to WU virus. A 2010 proposed classification recommended the division of the polyomaviruses into three genera, containing one genus of avian viruses and two of mammalian viruses; one of the latter was designated Wukipolyomavirus to indicate its two founding members. [13] In an updated classification system for the polyomavirus family proposed in 2016, WU virus is classified as a member of the genus Betapolyomavirus along with BK, JC, and KI. [2]

References

  1. 1 2 3 4 5 Allander, Tobias; Andreasson, Kalle; Gupta, Shawon; Bjerkner, Annelie; Bogdanovic, Gordana; Persson, Mats A. A.; Dalianis, Tina; Ramqvist, Torbjörn; Andersson, Björn (2007-04-01). "Identification of a third human polyomavirus". Journal of Virology. 81 (8): 4130–4136. doi:10.1128/JVI.00028-07. ISSN   0022-538X. PMC   1866148 . PMID   17287263.
  2. 1 2 Polyomaviridae Study Group of the International Committee on Taxonomy of, Viruses; Calvignac-Spencer, S; Feltkamp, MC; Daugherty, MD; Moens, U; Ramqvist, T; Johne, R; Ehlers, B (June 2016). "A taxonomy update for the family Polyomaviridae". Archives of Virology. 161 (6): 1739–50. doi: 10.1007/s00705-016-2794-y . hdl: 10037/13151 . PMID   26923930.
  3. 1 2 Gaynor, AM; Nissen, MD; Whiley, DM; Mackay, IM; Lambert, SB; Wu, G; Brennan, DC; Storch, GA; Sloots, TP; Wang, D (4 May 2007). "Identification of a novel polyomavirus from patients with acute respiratory tract infections". PLOS Pathogens. 3 (5): e64. doi: 10.1371/journal.ppat.0030064 . PMC   1864993 . PMID   17480120.
  4. 1 2 Abedi Kiasari, B; Vallely, PJ; Corless, CE; Al-Hammadi, M; Klapper, PE (September 2008). "Age-related pattern of KI and WU polyomavirus infection". Journal of Clinical Virology. 43 (1): 123–5. doi:10.1016/j.jcv.2008.05.003. PMC   7108349 . PMID   18573691.
  5. Yuan, XH; Jin, Y; Xie, ZP; Gao, HC; Xu, ZQ; Zheng, LS; Zhang, RF; Song, JR; Hou, YD; Duan, ZJ (October 2008). "Prevalence of human KI and WU polyomaviruses in children with acute respiratory tract infection in China". Journal of Clinical Microbiology. 46 (10): 3522–5. doi:10.1128/jcm.01301-08. PMC   2566089 . PMID   18667596.
  6. Bialasiewicz, S; Whiley, DM; Lambert, SB; Wang, D; Nissen, MD; Sloots, TP (September 2007). "A newly reported human polyomavirus, KI virus, is present in the respiratory tract of Australian children". Journal of Clinical Virology. 40 (1): 15–8. doi:10.1016/j.jcv.2007.07.001. PMC   7172449 . PMID   17706457.
  7. Kean, JM; Rao, S; Wang, M; Garcea, RL (March 2009). "Seroepidemiology of human polyomaviruses". PLOS Pathogens. 5 (3): e1000363. doi: 10.1371/journal.ppat.1000363 . PMC   2655709 . PMID   19325891.
  8. Nguyen, Nang L.; Le, Binh Minh; Wang, David (2009-08-01). "Serologic evidence of frequent human infection with WU and KI polyomaviruses". Emerging Infectious Diseases. 15 (8): 1199–1205. doi:10.3201/eid1508.090270. ISSN   1080-6059. PMC   2815979 . PMID   19751580.
  9. 1 2 Gossai, A; Waterboer, T; Nelson, HH; Michel, A; Willhauck-Fleckenstein, M; Farzan, SF; Hoen, AG; Christensen, BC; Kelsey, KT; Marsit, CJ; Pawlita, M; Karagas, MR (1 January 2016). "Seroepidemiology of Human Polyomaviruses in a US Population". American Journal of Epidemiology. 183 (1): 61–9. doi:10.1093/aje/kwv155. PMC   5006224 . PMID   26667254.
  10. Norja, P; Ubillos, I; Templeton, K; Simmonds, P (December 2007). "No evidence for an association between infections with WU and KI polyomaviruses and respiratory disease". Journal of Clinical Virology. 40 (4): 307–11. doi:10.1016/j.jcv.2007.09.008. PMC   7172997 . PMID   17997354.
  11. Dalianis, T; Hirsch, HH (15 March 2013). "Human polyomaviruses in disease and cancer". Virology. 437 (2): 63–72. doi:10.1016/j.virol.2012.12.015. PMID   23357733.
  12. Babakir-Mina, M; Ciccozzi, M; Perno, CF; Ciotti, M (August 2013). "The human polyomaviruses KI and WU: virological background and clinical implications". APMIS . 121 (8): 746–54. doi: 10.1111/apm.12091 . hdl: 2108/75668 . PMID   23782405. S2CID   38133334.
  13. Johne, R; Buck, CB; Allander, T; Atwood, WJ; Garcea, RL; Imperiale, MJ; Major, EO; Ramqvist, T; Norkin, LC (September 2011). "Taxonomical developments in the family Polyomaviridae". Archives of Virology. 156 (9): 1627–34. doi:10.1007/s00705-011-1008-x. PMC   3815707 . PMID   21562881.