Kari Nadeau

Last updated
Kari Nadeau
Kari CPMC gala BW cropped.jpg
NationalityAmerican
Alma mater
Known forEnvironmental Health & Disease
Scientific career
Fields
  • Allergy / Immunology / Asthma
  • Exposomics
  • Environmental Health
  • Clinical Trials
Institutions Harvard University
Stanford University
Thesis Biochemical studies on protein folding chaperones : Hsp90 and cyclophilin ; and, On trypanosomal enzymes : trypanothione and glutationylspermidine synthetases  (1995)
Doctoral advisor Christopher T. Walsh

Kari C. Nadeau is the Chair of the Department of Environmental Health at Harvard School of Public Health and John Rock Professor of Climate and Population Studies. [1] She is also adjunct professor at Stanford University in the Department of Pediatrics. [2] She practices Allergy, Asthma, Immunology in children and adults as a physician, and has published over 400 papers. [3] Her team focuses on quantifying health outcomes of solutions as they pertain to air pollution mitigation and adaptation at the local, regional, country, and global levels. Dr. Nadeau, with a team of individuals and patients and families, has been able to help major progress and impact in the clinical fields of exposomics, immunology, infection, asthma, and allergy. Dr. Nadeau is a member of the National Academy of Medicine [4] and the U.S. EPA Children’s Health Protection Committee. [5]

Contents

For more than 30 years, she has devoted herself to understanding how environmental and genetic factors affect the risk of developing human disease. Her laboratory has been studying pollution effects on children and adults. Many of the health issues involving individuals and the public are increasing because of air pollution and extreme weather conditions. She oversees a team working with a multidisciplinary group of community leaders, engineers, scientists, lawyers, and policy makers. Dr. Nadeau was appointed as a member of the U.S. Federal Wildfire Commission in 2022. [6]

Dr. Nadeau works with other organizations and institutes across the world. She works with the WHO on a scoping review and report for health ministers and policy makers on wildland fires and/or air pollution: how to mitigate, adapt, and follow UN SDG’s to create resiliency and co-benefits in communities, especially LMICs.

Dr. Nadeau and her team perform research in the prevention and therapy of disease. She also launched four biotech companies, [7] [8] [9] and founded the Climate Change and Health Equity Task Force and started the Sustainability Health Seed Grant initiative and Climate Change and Health Fellowship program. [10] She has served on the Scientific Advisory Board of the U.S. EPA.

She works as a member of the UNEA through Harvard to work on environmental health and planetary health governance and policy. [11] She is also a member of the Center for the Early Development of the Child scientific committee at Harvard. [12]

Dr. Nadeau is a Faculty Associate at The Salata Institute for Climate and Sustainability and works with the Harvard Global Health Initiative and with the FXB center for Health and Human Rights at Harvard University. She was the interim director of the Harvard Center for Climate, Health and the Global Environment until October 2024, when she was succeeded by Mary Rice. [13] Through these programs Dr. Nadeau works directly with Environmental Justice, global, regional, and local communities.

Her groundbreaking research has pioneered the field of allergies, asthma, and immunology, specifically in food allergies, pollution-induced asthma, and COVID-19. Dr. Nadeau’s studies have demonstrated that exposures to water and air pollution can modify the DNA of all ages of individuals and can lead to respiratory, allergic, and immune disorders. [14]

Education

After graduating from Haverford College with a degree in biology, [15] Nadeau attended Harvard Medical School via the Medical Scientist Training Program (NIH), and received a PhD in biological chemistry and molecular pharmacology and an MD in 1995. She then started an internship and residency in pediatrics. From 1998 to 2002, she worked in the field of biopharmaceuticals and led clinical research to obtain FDA approval for two biologics in the field of Autoimmunity and Oncology, respectively. From 2003 to 2006, Nadeau was a pediatric resident and a fellow in Asthma, Allergy, and Immunology. She also did a postdoctoral fellowship in human immune tolerance mechanisms in asthma and allergy. [16] She received a certificate in Public Policy from the Harvard Kennedy School in 2022.

Career

In 2006, Nadeau was appointed to the Stanford University School of Medicine with appointments in Pediatrics and Otolaryngology. In 2016 she was named the Naddisy Foundation Professor of Pediatric Food Allergy, Immunology and Asthma endowed professorship under the Naddisy Family Foundation. [17] Nadeau has served as a reviewer for NIH Study Sections, and a member of the American Lung Association Medical Board, CA. She serves on the Environmental Health Policy committee for the American Thoracic Society and is a Fellow in the American Academy of Allergy, Asthma and Immunology and is a member of ASCI (American Society of Clinical Investigation). [18] Her laboratory focuses on the study of immunological mechanisms involved in the cause, diagnosis, and therapy for allergy and asthma. [19] In December, 2014 Sean Parker donated $24 million to Stanford to establish the Sean N. Parker Center for Allergy Research at Stanford University, [20] with Nadeau as the director. [21] [22]

In September 2020, Dr. Kari Nadeau published The End of Food Allergy: The First Program To Prevent and Reverse a 21st Century Epidemic with co-author Sloan Barnett. [23]

As of January 2023, Nadeau is Chair of the Department of Environmental Health at Harvard TH Chan School of Public Health. [24]

Research

Monitoring cells and responses in human immunotherapy and their effect on immune tolerance

Translational work (through conducting novel and innovative clinical studies to induce tolerance through immunotherapy) on Treg function and epigenetic changes. [25] [26] [27]  This research led to novel findings on markers of immune tolerance in clinical trial using food  oral immunotherapy for near fatal food allergies. Dr. Nadeau and her team study how immune cells respond to therapy using human blood and organoids.

Multiple Pollution Exposomics

Dr. Nadeau oversees collaborative teams examining plasma, cellular, and epigenetic markers that are affected by pollution in children, adolescents, and adults. Using well characterized cohorts across the world (for acute pollution exposure—i.e. wildfire) and in the Central Valley of California (for chronic exposure—i.e. Fresno is one of the highest ranked cities in the country for PM2.5 air pollution), Dr. Nadeau and her team have been able to perform innovative and impactful research that has helped shape public policy towards mitigating pollution and its effects on the public, (especially those at risk populations (like children) and the underserved (like Hispanic populations in the Central Valley of California). [28] [29] [30] [31]

Solutions in Climate Change Mitigation and Adaptation

Working with a team of dedicated multidisciplinary experts, Dr. Nadeau focuses on quantifying the health outcomes of solutions that have been implemented to address climate change. For example, her team studies whether certain diseases are lessened by switching from diesel to electric vehicles, from gas to electric stoves, from no to cooling devices, or from no biodiversity to greening a local area. She focuses her research on those communities that are inequitably exposed to climate change and extreme weather. [32] [33] [34] [35] [36]

Honors and awards

Media

Nadeau and her work have made a number of media appearances supporting food allergy awareness and research:

Related Research Articles

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Anaphylaxis is a serious, potentially fatal allergic reaction and medical emergency that is rapid in onset and requires immediate medical attention regardless of the use of emergency medication on site. It typically causes more than one of the following: an itchy rash, throat closing due to swelling that can obstruct or stop breathing; severe tongue swelling that can also interfere with or stop breathing; shortness of breath, vomiting, lightheadedness, loss of consciousness, low blood pressure, and medical shock. These symptoms typically start in minutes to hours and then increase very rapidly to life-threatening levels. Urgent medical treatment is required to prevent serious harm and death, even if the patient has used an epipen or has taken other medications in response, and even if symptoms appear to be improving.

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<i>The Journal of Allergy and Clinical Immunology</i> Academic journal

The Journal of Allergy and Clinical Immunology (JACI) is a monthly peer-reviewed medical journal covering research on allergy and immunology. It is one of three official journals of the American Academy of Allergy, Asthma, and Immunology. The journal was established in 1929 as the Journal of Allergy and obtained its current name in 1971. The name change was purportedly related to a change in the attitude among physicians about the breadth of applicability of the term "allergy". The journal has been published under the Mosby imprint since its inception.

The Swiss Institute of Allergy and Asthma Research (SIAF) was founded in 1988 as an institution of the foundation Schweizerisches Forschungsinstitut für Hochgebirgsklima und Medizin SFI in Davos, Switzerland. SIAF is located at the Medicine Campus Davos, which opened in 2019. SIAF has been an affiliated institute of the University of Zurich since 1995.

Founded in 1943, the American Academy of Allergy, Asthma & Immunology (AAAAI) is a professional medical membership organization of more than 7,000 allergists/immunologists and related professionals around the world with advanced training and experience in allergy, asthma and other immunologic diseases. The Academy is dedicated to the advancement of the knowledge and practice of allergy, asthma and immunology for optimal patient care.

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References

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  2. ↑ "Kari Nadeau, MD, PhD's Profile | Stanford Profiles". profiles.stanford.edu. Retrieved 2024-01-08.
  3. ↑ "Kari Nadeau". connects.catalyst.harvard.edu. Retrieved 2024-01-02.
  4. ↑ "National Academy of Medicine Elects 100 New Members".
  5. ↑ "CHPAC Committee Members". 21 July 2020.
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  12. ↑ "Affiliated Faculty - Center on the Developing Child". Center on the Developing Child at Harvard University. Retrieved 2024-01-09.
  13. ↑ https://hsph.harvard.edu/climate-health-c-change/news/mary-rice-director/
  14. ↑ Aguilera, Juan; Han, Xiaorui; Cao, Shu; Balmes, John; Lurmann, Fred; Tyner, Tim; Lutzker, Liza; Noth, Elizabeth; Hammond, S. Katharine; Sampath, Vanitha; Burt, Trevor; Utz, P. J.; Khatri, Purvesh; Aghaeepour, Nima; Maecker, Holden (2022-03-14). "Increases in ambient air pollutants during pregnancy are linked to increases in methylation of IL4, IL10, and IFNγ". Clinical Epigenetics. 14 (1): 40. doi: 10.1186/s13148-022-01254-2 . ISSN   1868-7083. PMC   8919561 . PMID   35287715.
  15. ↑ "HAVERFORD-Spring-Summer-2013" (PDF).
  16. ↑ Nadeau, Kari C.; Callejas, Angel; Wong, Wendy B.; Joh, Jae Won; Cohen, Harvey J.; Jeng, Michael R. (December 2008). "Idiopathic neutropenia of childhood is associated with Fas/FasL expression". Clinical Immunology. 129 (3): 438–447. doi:10.1016/j.clim.2008.08.006. ISSN   1521-6616. PMC   4161459 . PMID   18819843.
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  21. ↑ "Techcrunch". Techcrunch.com. 17 December 2014. Retrieved 3 May 2015.
  22. ↑ "Why Sean Parker Gave $24 Million To Build A Stanford Allergy Research Center". Forbes.com. Retrieved 3 May 2015.
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  24. ↑ "Department of Environmental Health". Department of Environmental Health. 2024-01-16. Retrieved 2024-01-02.
  25. ↑ Kaushik, Abhinav; Dunham, Diane; Han, Xiaorui; Do, Evan; Andorf, Sandra; Gupta, Sheena; Fernandes, Andrea; Kost, Laurie Elizabeth; Sindher, Sayantani B.; Yu, Wong; Tsai, Mindy; Tibshirani, Robert; Boyd, Scott D.; Desai, Manisha; Maecker, Holden T. (2022-11-04). "CD8+ T cell differentiation status correlates with the feasibility of sustained unresponsiveness following oral immunotherapy". Nature Communications. 13 (1): 6646. doi: 10.1038/s41467-022-34222-8 . ISSN   2041-1723. PMC   9636180 . PMID   36333296.
  26. ↑ Prunicki, Mary; Cauwenberghs, Nicholas; Ataam, Jennifer Arthur; Movassagh, Hesam; Kim, Juyong Brian; Kuznetsova, Tatiana; Wu, Joseph C.; Maecker, Holden; Haddad, Francois; Nadeau, Kari (2022-11-28). "Correction: Immune biomarkers link air pollution exposure to blood pressure in adolescents". Environmental Health. 21 (1): 117. Bibcode:2022EnvHe..21..117P. doi: 10.1186/s12940-022-00916-1 . ISSN   1476-069X. PMC   9703689 . PMID   36443731.
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  29. ↑ Jung, Youn Soo; Sampath, Vanitha; Prunicki, Mary; Aguilera, Juan; Allen, Harry; LaBeaud, Desiree; Veidis, Erika; Barry, Michele; Erny, Barbara; Patel, Lisa; Akdis, Cezmi; Akdis, Mubeccel; Nadeau, Kari (2022-12-15). "Characterization and regulation of microplastic pollution for protecting planetary and human health". Environmental Pollution. 315: 120442. Bibcode:2022EPoll.31520442J. doi:10.1016/j.envpol.2022.120442. ISSN   0269-7491. PMID   36272609. S2CID   253037874.
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  33. ↑ Perera, Frederica; Nadeau, Kari (2022-06-16). Solomon, Caren G.; Salas, Renee N. (eds.). "Climate Change, Fossil-Fuel Pollution, and Children's Health". New England Journal of Medicine. 386 (24): 2303–2314. doi:10.1056/NEJMra2117706. ISSN   0028-4793. PMID   35704482.
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