LGSN

Last updated
LGSN
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases LGSN , GLULD1, LGS, lengsin, lens protein with glutamine synthetase domain
External IDs OMIM: 611470 MGI: 2672844 HomoloGene: 9569 GeneCards: LGSN
Orthologs
SpeciesHumanMouse
Entrez

51557

266744

Ensembl

ENSG00000146166

ENSMUSG00000050217

UniProt

Q5TDP6

Q8CIX8

RefSeq (mRNA)

NM_001143940
NM_016571

NM_153601

RefSeq (protein)

NP_001137412
NP_057655

NP_705829

Location (UCSC) Chr 6: 63.28 – 63.32 Mb Chr 1: 31.22 – 31.24 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Lengsin is a protein that in humans is encoded by the LGSN gene.

Contents

Lengsin is a survivor of an ancient family of class I glutamine synthetases in eukaryotes that has undergone evolutionary re-engineering for a tissue-specific, noncatalytic role in the lens of the vertebrate eye. [5] Lengsin is the result of the recruitment of an ancient enzyme may act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. It does not seem to have enzymatic activity.

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000146166 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050217 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Wyatt K, Gao C, Tsai JY, Fariss RN, Ray S, Wistow G (March 2008). "A role for lengsin, a recruited enzyme, in terminal differentiation in the vertebrate lens". The Journal of Biological Chemistry. 283 (10): 6607–15. doi: 10.1074/jbc.M709144200 . PMC   2911820 . PMID   18178558.

Further reading

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