LSM8

Last updated
LSM8
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases LSM8 , NAA38, LSM8 homolog, U6 small nuclear RNA associated
External IDs OMIM: 607288 MGI: 1923772 HomoloGene: 9419 GeneCards: LSM8
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016200

NM_133939

RefSeq (protein)

NP_057284

NP_598700

Location (UCSC) Chr 7: 118.18 – 118.2 Mb Chr 6: 18.85 – 18.86 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

U6 snRNA-associated Sm-like protein LSm8 is a protein that in humans is encoded by the LSM8 gene. [5] [6]

Contents

This gene is a member of the LSm family and encodes a protein with a closed barrel shape, made up of five anti-parallel beta strands and an alpha helix. The protein partners with six paralogs to form a heteroheptameric ring which transiently binds RNAs and is involved in the general maturation of RNA in the nucleus. [6]

Interactions

LSM8 has been shown to interact with LSM2. [7] [8]

Related Research Articles

<span class="mw-page-title-main">HLA-B associated transcript 3</span> Protein-coding gene in the species Homo sapiens

Large proline-rich protein BAT3 is a protein that in humans is encoded by the BAT3 gene.

<span class="mw-page-title-main">LSM6</span> Protein-coding gene in the species Homo sapiens

U6 snRNA-associated Sm-like protein LSm6 is a protein that in humans is encoded by the LSM6 gene.

<span class="mw-page-title-main">LSM5</span> Protein-coding gene in the species Homo sapiens

U6 snRNA-associated Sm-like protein LSm5 is a protein that in humans is encoded by the LSM5 gene.

<span class="mw-page-title-main">LSM4</span> Protein-coding gene in the species Homo sapiens

U6 snRNA-associated Sm-like protein LSm4 is a protein that in humans is encoded by the LSM4 gene.

<span class="mw-page-title-main">LSM1</span> Protein-coding gene in the species Homo sapiens

U6 snRNA-associated Sm-like protein LSm1 is a protein that in humans is encoded by the LSM1 gene.

<span class="mw-page-title-main">LSM3</span> Protein-coding gene in the species Homo sapiens

U6 snRNA-associated Sm-like protein LSm3 is a protein that in humans is encoded by the LSM3 gene.

<span class="mw-page-title-main">Exosome component 9</span> Protein-coding gene in the species Homo sapiens

Exosome component 9, also known as EXOSC9, is a human gene, the protein product of which is part of the exosome complex and is an autoantigen is patients with certain auto immune diseases, most notably scleromyositis.

<span class="mw-page-title-main">LSM7</span> Protein-coding gene in the species Homo sapiens

U6 snRNA-associated Sm-like protein LSm7 is a protein that in humans is encoded by the LSM7 gene.

<span class="mw-page-title-main">SKIV2L2</span> Protein-coding gene in the species Homo sapiens

Superkiller viralicidic activity 2-like 2 is a protein that in humans is encoded by the SKIV2L2 gene.

<span class="mw-page-title-main">LSM2</span> Protein-coding gene in the species Homo sapiens

U6 snRNA-associated Sm-like protein LSm2 is a protein that in humans is encoded by the LSM2 gene.

<span class="mw-page-title-main">DYNLRB1</span> Protein-coding gene in the species Homo sapiens

Dynein light chain roadblock-type 1 is a protein that in humans is encoded by the DYNLRB1 gene.

<span class="mw-page-title-main">DOM3Z</span> Protein-coding gene in the species Homo sapiens

Protein Dom3Z is a protein that in humans is encoded by the DOM3Z gene.

<span class="mw-page-title-main">NOMO1</span> Protein-coding gene in the species Homo sapiens

Nodal modulator 1 is a protein that in humans is encoded by the NOMO1 gene.

<span class="mw-page-title-main">40S ribosomal protein S15a</span> Protein-coding gene in the species Homo sapiens

40S ribosomal protein S15a is a protein that in humans is encoded by the RPS15A gene.

<span class="mw-page-title-main">KIAA0460</span> Protein-coding gene in the species Homo sapiens

Regulation of nuclear pre-mRNA domain-containing protein 2 is a protein that in humans is encoded by the RPRD2 gene.

<span class="mw-page-title-main">Probable ribosome biogenesis protein RLP24</span> Protein-coding gene in the species Homo sapiens

Probable ribosome biogenesis protein RLP24 is a protein that in humans is encoded by the RSL24D1 gene.

<span class="mw-page-title-main">ZNF44</span> Protein-coding gene in the species Homo sapiens

Zinc finger protein 44 is a protein that in humans is encoded by the ZNF44 gene.

<span class="mw-page-title-main">TSEN15</span> Protein-coding gene in the species Homo sapiens

tRNA-splicing endonuclease subunit Sen15 is an enzyme that in humans is encoded by the TSEN15 gene.

<span class="mw-page-title-main">RHOXF1</span> Protein-coding gene in the species Homo sapiens

Rhox homeobox family member 1 is a protein that in humans is encoded by the RHOXF1 gene.

<span class="mw-page-title-main">NOB1</span> Protein-coding gene in the species Homo sapiens

RNA-binding protein NOB1 is a protein that in humans is encoded by the NOB1 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000128534 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044155 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Achsel T, Brahms H, Kastner B, Bachi A, Wilm M, Luhrmann R (Dec 1999). "A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro". EMBO J. 18 (20): 5789–802. doi:10.1093/emboj/18.20.5789. PMC   1171645 . PMID   10523320.
  6. 1 2 "Entrez Gene: LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae)".
  7. Lehner, Ben; Sanderson Christopher M (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. ISSN   1088-9051. PMC   442147 . PMID   15231747.
  8. Lehner, Ben; Semple Jennifer I; Brown Stephanie E; Counsell Damian; Campbell R Duncan; Sanderson Christopher M (Jan 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. ISSN   0888-7543. PMID   14667819.

Further reading