List of Fantastic Four enemies

The Marvel Universe debuted in the pages of Fantastic Four in 1961, created by Stan Lee and Jack Kirby. At that time, Strange Tales also published stories featuring the Fantastic Four cast, mostly the Human Torch and Thing, where other villains also debuted. The following is a list of antagonists that were introduced in Fantastic Four, Strange Tales and other Marvel comics. The Fantastic Four is regarded as possessing one of the strongest rogues' galleries in Marvel Comics. ^[1]

Fantastic Four debuts

Supervillain name	Notable alter ego	First appearance issue #	Creator	Notes
Mole Man and his Moloids	Harvey Rupert Elder	Fantastic Four No. 1 (November 1961)	Stan Lee Jack Kirby	An underground leader of Subterranea, who plans to take over the outer world that rejected him. Rules over different creatures and has access to highly advanced technology.
Skrulls	Various	Fantastic Four No. 2 (January 1962)	Stan Lee Jack Kirby	An alien race that can shapeshift and are bent on taking over the Earth.
Miracle Man	Joshua Ayers	Fantastic Four No. 3 (March 1962)	Stan Lee Jack Kirby	A magician with megalomaniacal goals.
Namor the Sub-Mariner	Namor McKenzie	Fantastic Four No. 4 (May 1962)	Bill Everett	An underwater antihero who tried to win Invisible Woman's heart. He is the King of Atlantis. Originally the character was created for the Invaders for Timely Comics, and was reintroduced into Marvel Comics in 1962.
Doctor Doom	Victor von Doom	Fantastic Four No. 5 (July 1962)	Stan Lee Jack Kirby	The Fantastic Four's deadliest archenemy. Ruler of Latveria, bent on dominating the Earth. A skilled sorcerer and one of the smartest people on Earth 616. Met Reed Richards and Ben Grimm while at college at the fictional Empire State University. He was permanently disfigured after an accident in which he tried contacting his deceased mother from beyond the grave. This disfigurement was only made worse when he prematurely put on his iconic mask before it was cool. One of Marvel's biggest and most popular villains. While typically an enemy of the Fantastic Four, he has been known to help them, such as with the birth of Valeria Richards. [2]
Kurrgo	Kurrgo	Fantastic Four No. 7 (July 1962)	Stan Lee Jack Kirby	A Xantha who is the dictator of the planet Xanth and master of its technology that is more advanced than Earth's technology. He had his robot bring the Fantastic Four to Xantha to help save his kind from an asteroid that will destroy Xanth. When Mister Fantastic came up with a way to shrink the Xanthas with a special gas in order to save them and relocate them to another planet by enlarging them, Kurrgo still plotted to rule his kind. Though he was thought to have perished in Xanth's destruction, Marvel Feature #11 revealed that Kurrgo's robot saved him and took him to a hidden spaceship which they used to escape Xanth's destruction. In order to regain control of the Xantha who have settled on New Xanth and repelled him with their technology, Kurrgo and his robot went to Earth to plan to use Thing in overcoming the Xantha only to end up competing against Leader after discovering that Hulk was stronger than Thing.
Puppet Master	Phillip Masters	Fantastic Four No. 8 (Nov. 1962)	Stan Lee Jack Kirby	An artist that can control people with puppets he creates in their image using special radioactive clay. Is the step-father of Alicia Masters, Ben Grimm's future wife.
Impossible Man		Fantastic Four No. 11 (Feb 1963)	Stan Lee Jack Kirby	An alien that can shapeshift from the planet Poppup. He has a hivemind containing all the consciousnesses of Poppup before it was consumed by Galactus. [3]
Red Ghost and his Super-Apes	Ivan Kragoff	Fantastic Four No. 13 (April 1963)	Stan Lee Jack Kirby	A ghost-like figure with three super-powered primates. A Soviet scientist who uses the same technology as the Fantastic Four to make it to the moon.
Mad Thinker and his Awesome Android	Julius	Fantastic Four No. 15 (Jun 1963)	Stan Lee Jack Kirby	A genius specializing in evil robotics who usually comes up with very elaborate, infallible, devious plans that unfold like clockwork.
Super-Skrull	Kl'rt	Fantastic Four No. 18 (Sep. 1963)	Stan Lee Jack Kirby	A Skrull with the combined powers of the Fantastic Four and also hypnosis.
Rama-Tut	Nathaniel Richards	Fantastic Four No. 19 (Oct. 1963)	Stan Lee Jack Kirby	One of the many names of Kang the Conqueror, an Avengers villain and Reed Richard's descendant.
Molecule Man	Owen Reece	Fantastic Four No. 20 (November 1963)	Stan Lee Jack Kirby	A villain or a reluctant hero with the power of molecular manipulation. Originally could only control inorganic matter, but can now control organic matter as well.
Hate-Monger	Clone of Adolf Hitler	Fantastic Four No. 21 (December 1963)	Stan Lee Jack Kirby
Infant Terrible		Fantastic Four No. 24 (March 1964)	Stan Lee Jack Kirby
Diablo	Esteban Corazón de Ablo	Fantastic Four No. 30 (September 1964)	Stan Lee Jack Kirby	An evil alchemist from medieval Spain who controls the Four Elements
Attuma		Fantastic Four No. 33 (December 1964)	Stan Lee Jack Kirby	An Atlantean who is also Namor's archenemy.
Dragon Man		Fantastic Four No. 35 (February 1965).	Stan Lee Jack Kirby	A robot in the form of a humanoid dragon that was brought to life by Diablo. He later gains intelligence and sentience, becoming an ally and teacher to the Future Foundation.
Frightful Four		Fantastic Four No. 36 (March 1965)	Stan Lee Jack Kirby	The evil version of the Fantastic Four. Led by the Human Torch's enemy Wizard. The lineup frequently changes, with founding members Wizard, Medusa, Sandman, and Paste-Pot Pete.
Maximus the Mad	Maximus Boltagon	Fantastic Four No. 47 (Feb. 1966)	Stan Lee Jack Kirby	A member of the Inhumans who wants to take over his brother and archenemy Black Bolt's reign as ruler of the Inhumans.
Galactus		Fantastic Four No. 48 (March 1966)	Stan Lee Jack Kirby	A gigantic cosmic entity that feeds on planets. Also the Silver Surfer's archenemy and frequent master.
Klaw	Ulysses Klaue	Fantastic Four No. 56 (Nov 1966)	Stan Lee Jack Kirby	A human physicist who has been transformed into solid sound and who wears a sonic emitter on his right wrist as a prosthetic device. Also known as an enemy of Black Panther.
Blastaar		Fantastic Four No. 62 (May 1967)	Stan Lee Jack Kirby	A villain from the Negative Zone with the power to project blasts of highly concussive kinetic force from his hands.
Ronan the Accuser		Fantastic Four No. 65 (Aug. 1967)	Stan Lee Jack Kirby	The Supreme Accuser of the Kree Empire.
Kree		Fantastic Four No. 65 (Aug. 1967)	Stan Lee Jack Kirby	A scientifically and technologically advanced militaristic alien race.
Psycho-Man		Fantastic Four Annual No. 5 (Nov. 1967)	Stan Lee Jack Kirby	A member of a microscopic race who can manipulate emotions.
Annihilus		Fantastic Four Annual No. 6 (November 1968)	Stan Lee Jack Kirby	A villain from the Negative Zone that wields a cosmic control rod to take over the Earth.
Overmind		Fantastic Four No. 113 (August 1971)	Stan Lee John Buscema	An alien belonging to the Eternals.
Air-Walker	Gabriel Lan	Fantastic Four No. 120 (March 1972)	Stan Lee John Buscema	The Xandarian Herald of Galactus.
Nicholas Scratch		Fantastic Four No. 185 (August 1977)	Len Wein George Pérez	A wizard and the son of Fantastic Four supporting character Agatha Harkness.
Salem's Seven		Fantastic Four No. 186 (September 1977)	Len Wein George Pérez	A team of seven magical supervillains that are children of Nicholas Scratch and grandchildren of Agatha Harkness.
Terrax the Tamer	Tyros	Fantastic Four No. 211 (Oct. 1979)	Marv Wolfman John Byrne Joe Sinnott Ben Sean	A Herald of Galactus who later betrayed him.
Karisma	Mary Brown	Fantastic Four #266 (May, 1984)	John Byrne	Mary Brown is a supervillain who uses radiation wavelengths to become irresistible to men.
Kristoff Vernard	Kristoff von Doom	Fantastic Four No. 247 (October 1982)	John Byrne	Someone who takes the identity of Doctor Doom for a while before becoming an ally for the Fantastic Four. Originally Doctor Doom's heir apparent.
Terminus		Fantastic Four No. 269 (August 1984)	John Byrne	An alien destroyer.
Fasaud		Fantastic Four No. 308 (November 1987)	Steve Englehart and John Buscema	A man transformed into a living electronic image.
Paibok the Power Skrull		Fantastic Four No. 358 (November 1991)	Tom DeFalco Paul Ryan Danny Bulanadi	A powerful Skrull.
Devos the Devastator		Fantastic Four No. 359 (December 1991)	Tom DeFalco Paul Ryan Danny Bulanadi	An extraterrestrial vigilante dedicated to bringing peace to the universe, but holds the rather warped view that this can only be done by destroying anyone whom he deems a threat to galactic peace.
Occulus		Fantastic Four No. 363 (Apr 1992)	Tom DeFalco Paul Ryan	One of the first villains imprisoned in the Negative Zone prison.
Hyperstorm	Johnathon Richards	Fantastic Four No. 406 (November 1995)	Tom DeFalco Paul Ryan Dan Bulanadi	Reed and Sue's grandson from the future and an enemy of the Fantastic Four.
Abraxas		Fantastic Four Annual 2001 (September 2001)	Carlos Pacheco	A cosmic entity who seeks to destroy all realities.
Salamandra		Fantastic Four No. 514 (August 2004)	Paco Medina	A half-human/half-dragon woman who is the Wizard's ex-wife.
Quiet Man	possibly "John Eden"	Fantastic Four Vol. 5 No. 5 (July 2014)	James Robinson Leonard Kirk	A genius level intellect who considers himself Reed's arch-rival.
Victorious	Zora Vukovic	Fantastic Four Vol. 6 No. 1 (October 2018)	Dan Slott Simone Bianchi	A dedicated patriot and freedom fighter in her homeland of Latveria, she was given cosmic powers bestowed by Doctor Doom.

Strange Tales debuts

Supervillain name	Notable alter ego	First appearance issue #	Creator	Notes
Wizard	Bentley Wittman	Strange Tales No. 102 (Nov 1962)	Stan Lee Larry Lieber Jack Kirby	An enemy of the Human Torch and the founder of the Frightful Four.
Paste-Pot Pete/Trapster	Peter Petruski	Strange Tales No. 104 (January 1963)	Stan Lee Jack Kirby	An original member of the Frightful Four, Trapster can trap people with adhesives or lubricants.

Other titles debuts

Supervillain name	Notable alter ego	First appearance issue #	Creator	Notes
Kang the Conqueror	Nathaniel Richards	Avengers No. 8 (Sep. 1964)	Stan Lee Jack Kirby	This prime Avengers villain has many ties to the team and has had more than a few battles with the Fantastic Four as well.
Immortus	Nathaniel Richards	Avengers No. 10 (Nov 1964)	Stan Lee Jack Kirby	The future version of Kang the Conqueror.
Ego the Living Planet		Thor No. 132 (September 1966)	Stan Lee Jack Kirby	A powerful living planet that is primarily a villain of Thor.
Mephisto		Silver Surfer No. 3 (Dec. 1968)	Stan Lee John Buscema	This Prince of Darkness has tried to tamper with the souls of the Fantastic Four and will most likely try to do it again. One of the Ghost Rider's archenemies, besides Blackheart.
Living Monolith	Ahmet Abdol	X-Men No. 54 (Mar 1969)	Arnold Drake Roy Thomas Don Heck Neal Adams	An X-Men villain who was the Living Pharaoh while in his normal appearance, but once he obtained enough cosmic energy, he would increase in mass, size and power, thus becoming the Living Monolith.
Llyra		Sub-Mariner No. 32 (December 1970)	Roy Thomas Sal Buscema	A female Atlantean who is also an enemy of Namor.
Brute	Reed Richards of Counter-Earth	Marvel Premiere No. 2 (May 1972)	Roy Thomas Gil Kane	An evil counterpart of Reed Richards from Counter-Earth.
Aron		Captain Marvel No. 39 (Jul 1975)	Steve Englehart Al Milgrom	A rogue Watcher that likes to manipulate the Fantastic Four.
Ion	Voletta Todd	Machine Man #15 (June 1980)	Tom DeFalco Steve Ditko	Violetta Todd is the niece of Blazing Skull who projects electromagnic energy.
Beyonder		Secret Wars No. 1 (May 1984)	Jim Shooter Mike Zeck	A sentient universe come to Earth in human form to study humanity.
Lucia von Bardas		Secret War No. 1 (February 2004)	Brian Michael Bendis Gabriele Dell'Otto	A woman cyborg from Latveria.
Maker	Reed Richards	Ultimate Fantastic Four No. 1 (February 2004)	Brian Michael Bendis Mark Millar Adam Kubert	The Ultimate Marvel version of Reed Richards who became corrupt.

Other major villains

Stan Lee and Jack Kirby collaborated on the first 102 consecutive issues of Fantastic Four. Most of the major Marvel concepts, i.e., Latveria, Atlantis, Wakanda, Attilan, the Negative Zone, the Microverse, Subterranea and Avalon which later became a huge part of other major Marvel characters, debuted in Fantastic Four. Following are some of the villains who have gone on to become major villains of various Marvel franchises.

Supervillain name	Franchise	First appearance issue #
Skrulls	Marvel Universe	Fantastic Four No. 2 (January 1962)
Immortus (Kang the Conqueror)	Avengers	Fantastic Four No. 19 (Oct. 1963)
Molecule Man	Marvel Universe	Fantastic Four No. 20 (November 1963)
Attuma	Namor	Fantastic Four No. 33 (December 1964)
Maximus the Mad	Inhumans	Fantastic Four No. 47 (Feb. 1966)
Galactus	Silver Surfer	Fantastic Four No. 48 (March 1966)
Klaw	Black Panther	Fantastic Four No. 56 (Nov 1966)
Kree	Marvel Universe	Fantastic Four No. 65 (Aug. 1967)
Enclave	Adam Warlock	Fantastic Four No. 66 (Sep. 1967)
Annihilus	Marvel Universe	Fantastic Four Annual No. 6 (November 1968)

References

1. Nerdist
2. Fantastic Four Vol 3 #54. (June 2002)
3. Fantastic Four #175(July, 1976)