List of adverse effects of chlorpromazine

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Chlorpromazine includes the following list of adverse effects (serious adverse effects appear in bold): [Note 1] [1] [2] [3] [4] [5]

Contents

Very common

Common

Uncommon

Rare

Unknown frequency

Notes

  1. ↑ Data on the exact incidence of the different adverse effects is greatly lacking so only rough approximations of adverse effect incidence is available
  2. ↑ Refer to main text below for details on this adverse effect
  3. ↑ A drop in blood pressure that results from standing up
  4. ↑ A disturbance in the electrical cycle of the heart
  5. ↑ Elevated serum levels of the lactation-related hormone prolactin. This in turn can result, in the short term, at least, in galactorrhoea (lactation that is unrelated to pregnancy or breastfeeding), gynaecomastia (swollen breast tissue), sexual dysfunction and amenorrhoea (the absence of the menstrual period in women). Whereas in the long-term hyperprolactinaemia can result in osteoporosis (brittle bones).
  6. ↑ An impaired ability to regulate one's body temperature
  7. ↑ High blood glucose (sugar) levels
  8. ↑ The hypothalamus of the brain regulates the release of a number of hormones as well as a few "housekeeping" functions such as tight control over body temperature
  9. ↑ Widening (dilation) of the pupils
  10. ↑ Refer to the text below for details
  11. ↑ Constriction of the pupils of the eyes
  12. ↑ Being unable to pass urine
  13. ↑ Glucose (sugar) in the urine due to there being too much glucose in the blood for the kidneys to reabsorb it all when filtrate goes through loop of henle in the nephrons of the kidney.
  14. ↑ Low blood glucose (sugar)
  15. ↑ Basically an exaggerated form of leucopaenia. It occurs when the white blood cell (WBC) count drops below 5% of the norm
  16. ↑ Where the number of red blood cells of the body die breakdown to an abnormal extent. These cells carry oxygen across the body from the lungs
  17. ↑ Where the bone marrow stops adequately (in order to replenish the blood cells that die off every day) producing new blood cells
  18. ↑ An abnormality in the electrical activity of the heart which can lead to potentially fatal changes in heart rhythm
  19. ↑ Dangerously (in the short-term) high blood pressure
  20. ↑ A dangerous skin reaction
  21. ↑ An autoimmune reaction
  22. ↑ A potentially fatal collection of symptoms (i.e. syndrome) that results from an abnormally excessive release of antidiuretic hormone (ADH). This in turn increases the reabsorption of
  23. ↑ A potentially fatal condition that is caused by dopamine receptor-blocking agents such as antipsychotics. It develops over a period of days or weeks and is characterised by rigidity, tremor, diarrhoea, tachycardia, altered mental status (e.g. confusion, mania, hallucinations, etc.) and hyperthermia (high body temperature)
  24. ↑ An autoimmune condition in of which the body's defences attack the neuromuscular junction – the gap between muscle and nerve cells across which the nerves send messages to the muscle cells
  25. ↑ An abnormally low number of white blood cells in the blood. These cells defend the body from infections and hence this can heighten one's risk of infections
  26. ↑ An abnormally high number of eosinophils – the cells of the immune system that defends the body from parasites
  27. ↑ An abnormally low number of all three major groups of blood cells including the red blood cells, white blood cells and platelets
  28. ↑ A painful and sustained (usually a few hours) erection
  29. ↑ Fear of light
  30. ↑ A reduction in the normal homeostatic breathing reaction to reductions in plasmacarbon dioxide levels
  31. ↑ High body temperature
  32. ↑ Low body temperature
  33. ↑ Lactation that is unassociated with lactation or breastfeeding
  34. ↑ The accumulation of fluid in the tissues of the brain
  35. ↑ Basically the opposite to euphoria
  36. ↑ The absence of menstrual periods
  37. ↑ An often irreversible and sometimes even fatal movement disorder characterised by involuntary, repetitive and purposeless movements of the face, extremities, lips or tongue. Usually takes a number of years to develop but in some it can appear within months or less since the initiation of antipsychotic treatment

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References

  1. ↑ "PRODUCT INFORMATION LARGACTIL" (PDF). TGA eBusiness Services. Sanofi Aventis Pty Ltd. 28 August 2012. Retrieved 8 December 2013.
  2. ↑ "Chlorpromazine Hydrochloride 100mg/5ml Oral Syrup - Summary of Product Characteristics (SPC)". electronic Medicines Compendium. Rosemont Pharmaceuticals Limited. 6 August 2013. Retrieved 8 December 2013.
  3. ↑ "CHLORPROMAZINE HYDROCHLORIDE tablet, film coated [Sandoz Inc]". DailyMed. Sandoz Inc. October 2011. Retrieved 8 December 2013.
  4. ↑ "CHLORPROMAZINE HYDROCHLORIDE injection [West-ward Pharmaceutical Corp.]". DailyMed. West-ward Pharmaceutical Corp. June 2012. Retrieved 8 December 2013.
  5. ↑ "Largactil Injection - Summary of Product Characteristics". electronic Medicines Compendium. Sanofi. 10 May 2013. Retrieved 8 December 2013.
  6. ↑ A number of doctors and scientists, including psychiatrist and Narcological doctor Alexander Danilin and biochemist Albert Szent-Györgyi, claim that Chlorpromazine stably and for life alters natural processes in the biological systems of the mitochondria of the nervous system, and inhibits the efficiency of the electron transport chain.
  7. ↑ "Bioenergetics by Szent-Györgyi, Albert. 1893-1986". New York, Academic Press. 1957.
  8. ↑ "Danilin A.G.: Beware of psychiatry: myths, neuroleptics and children". youtube.com. 13 April 2011.
  9. ↑ "Psychiatric drugs impact mitochondrial function in brain and other tissues".
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