| Name | Media | Work | Notes |
|---|
| Alphys | Video game | Undertale | A stout reptile-monster that is the Royal Scientist, a position she earned by creating a robot with a SOUL. She is a timid Otaku and cannot be battled. She has a crush on Undyne and Asgore, captain of the royal guard and king of the underground, respectively. |
| Bad Bill | Animation | Rango | A Gila monster |
| Bill the Lizard | Literature | Alice in Wonderland | A green lizard - it's not mentioned what kind. |
| Bing | Animation | The Angry Beavers | Voiced by Victor Wilson. He is an obnoxious and clingy lizard that always bugs Norbert and Daggett. He also has a girlfriend named Wanda who once broke up with him. |
| Budzo | Animation | Adventures in Zambezia | A sinister Rock monitor who tried to takes over Zambezia. |
| Chameleon | Animation | T.U.F.F. Puppy | An evil and devious chameleon in a molecular transformation suit, which allows him to shapeshift into virtually any disguise or inanimate object. |
| Chet Gecko | Literature | The Chameleon Wore Chartreuse | A detective whose specialty is working dangerously. |
| Chuck and Leon | Animation | Rocko's Modern Life | Chameleon brothers |
| Dimitri | Video game | Sly Cooper | A vain, French marine iguana artist/frogman who speaks using Hip-hop slang. In Sly 2, he is fought as an antagonist who forges paintings and is a member of the Klaww Gang. In Sly 3 and 4, he is an ally to the Cooper gang, helping them after they retrieve his grandfather's diving gear. |
| Chameleon | Animation | Lily to Kaeru to (Otouto) | A chameleon. |
| Espio | Video game | Knuckles' Chaotix | An anthropomorphic chameleon who is a ninja warrior. |
| Flick | Video game | Animal Crossing: New Horizons | An anthropromorphic, red chameleon. He buys the player's bugs, makes bug model commissions, and runs a season bug catching tourney. |
| Gaspar Le'Gecko | Animation | Brandy and Mr. Whiskers | A gecko. |
| Geico Gecko | Television | GEICO commercials | A gecko that looks similar to a day gecko. |
| Gex | Video game | Gex | A gecko. |
| Goanna | Animation | FernGully: The Last Rainforest | |
| Gosha | Comic | Beastars | A monitor lizard who is Legoshi's grandfather. |
| Henry | Animation | Henry's Amazing Animals | A lizard. |
| Ihu | Theme park | Aquatica | |
| Izzy | Animation | The Loud House | Lana Loud's pet gecko. He seems to have been used as a replacement for her former pet frog, Seymour. |
| Joanna | Animation | The Rescuers Down Under | A goanna who is McLeach's pet and acts to terrify her captives. |
| Knuckles | Animation | Quack Pack | Daisy Duck's pet iguana. |
| Komodo | Animation | The Secret Saturdays | |
| Komodo Dragon | Video game | Block Tales | A komodo dragon who fights the main protagonist, mistaking them for the villains who covered and destroyed her home. |
| Komodo Joe, Komodo Moe | Video game | Crash Bandicoot series | Two villainous Komodo dragon brothers. |
| Liz | Literature | The Magic School Bus | An anthropomorphic class pet lizard. |
| Lizardman | Myth and folklore | Worldwide | An anthromorphic lizard |
| Leon Powalski | Video game | Star Fox | A chameleon fighter pilot and a member of Star Wolf. |
| Meatball | Animation | The Casagrandes | An iguana owned by Adelaide Chang. |
| Mr. Dupette | Animation | Rocko's Modern Life | A lizard. |
| Nat | Video game | Animal Crossing | A green chameleon that runs the bug catching tourney in Animal Crossing (City Folk and New Leaf). |
| Noi Crezant | Comic | Hoshi no Samidare | A lizard |
| Mr. E | Animation | Work It Out Wombats! | A shopkeeper iguana. |
| Mrs Kipling | Television | Jessie | Ravi's pet water monitor |
| Private I. Guana | Literature | Private I. Guana: The Case of the Missing Chameleon | A detective iguana in search of Leon the missing chameleon. |
| Pascal | Animation | Tangled | Rapunzel's pet chameleon. |
| Rango | Animation | Rango | A pet chameleon who becomes lost in the Mojave Desert. |
| Ruff | Animation | Blinky Bill | |
| Roderick Lizzard | Animation | Bonkers | An actorly iguana. |
| Target | Live-action/Animation | Wild Kratts | A male Parson's chameleon that first appeared in Chameleons on Target. Martin named him that because he's always on target. |
| Vinnie Terrio | Animation | Littlest Pet Shop (2012 TV series) | A male green gecko with purple eyes |
