Lori Ann Setton

Last updated
Lori Ann Setton
Born
Queens, New York, US
Alma mater Princeton University
Columbia University
Known for mechanics
mechanobiology of the intervertebral disc
articular cartilagemechanics
drug delivery
pathomechanisms of osteoarthritis
Awards AIMBE Fellow (2005)
BMES Fellow (2009)
Van C. Mow Medal(2007)
Scientific career
FieldsBiomechanical Engineer
Institutions Washington University in St. Louis, Duke University
Doctoral advisor Van C. Mow
Website engineering.wustl.edu/Profiles/Pages/Lori-Setton.aspx

Lori Ann Setton is an American biomechanical engineer noted for her research on mechanics and mechanobiology of the intervertebral disc, articular cartilage mechanics, drug delivery, and pathomechanisms of osteoarthritis. She is currently the department chair as well as the Lucy and Stanley Lopata Distinguished Professor of Biomedical Engineering at McKelvey School of Engineering at Washington University in St. Louis.

Contents

Biography

Setton was born in Queens, New York. She received a B.S.E. in Mechanical and Aerospace Engineering from Princeton University in 1984. Subsequently, she pursued graduate degrees under the tutelage of Professor Van C. Mow at Columbia University. She received an M.S. degree and Ph.D degree in Mechanical Engineering/Biomechanics in 1988 and 1993, respectively.

She joined the Department of Biomedical Engineering at Duke University as an assistant professor in 1995. Promotions to tenured associate professor in and professor followed in 2004 and 2007.

Her most noticeable work has documented the biological responses of cartilage and intervertebral disc to mechanical loading, [1] [2] [3] [4] [5] [6] understanding a role for collagen genetic mutations in onset of arthritis and intervertebral disc pathology, [7] [8] development of injectable hydrogels for articular cartilage repair, [9] [10] [11] [12] and development of injectable drug delivery vehicles for fighting inflammation in musculoskeletal disease. [13] [14] [15] [16] [17] As of June 1, 2017, her work has been cited over 17,500 times. [18] She has an h-index of 65.

Awards

Setton has several awards:

References

  1. ↑ Setton, LA; Chen, J (2006). "Mechanobiology of the intervertebral disc and relevance to disc degeneration". J Bone Joint Surg Am. 88 (2): 52–57. doi:10.2106/JBJS.F.00001. PMID   16595444.(cited 154 times)
  2. ↑ Setton, LA; Mow, VC; Müller, FJ; Pita, JC; Howell, DS (1994). "Mechanical properties of canine articular cartilage are significantly altered following transection of the anterior cruciate ligament". Journal of Orthopaedic Research. 12 (4): 451–463. doi:10.1002/jor.1100120402. PMID   8064477. S2CID   41257875.(cited 168 times)
  3. ↑ LeRoux, MA; Arokoski, J; Vail, TP; Guilak, F; Hyttinen, MM; Kiviranta, I; Setton, LA (2000). "Simultaneous changes in the mechanical properties, quantitative collagen organization, and proteoglycan concentration of articular cartilage following canine meniscectomy". Journal of Orthopaedic Research. 18 (3): 383–392. doi:10.1002/jor.1100180309. PMID   10937624. S2CID   1697626.(cited 122 times)
  4. ↑ Leroux, MA; Cheung, HS; Bau, JL; Wang, JY; Howell, DS; Setton, LA (2001). "Altered mechanics and histomorphometry of canine tibial cartilage following joint immobilization". Osteoarthritis and Cartilage. 9 (7): 633–640. doi: 10.1053/joca.2001.0432 . PMID   11597176.(cited 62 times)
  5. ↑ Boyd, LM; Richardson, WJ; Chen, J; Kraus, VB; Tewari, A; Setton, LA (2005). "Osmolarity regulates gene expression in intervertebral disc cells determined by gene array and real-time quantitative RT-PCR". Annals of Biomedical Engineering. 33 (8): 1071–1077. CiteSeerX   10.1.1.419.5226 . doi:10.1007/s10439-005-5775-y. PMID   16133915. S2CID   18286177.(cited 35 times)
  6. ↑ Chen, J; Yan, W; Setton, LA (2004). "Static compression induces zonal-specific changes in gene expression for extracellular matrix and cytoskeletal proteins in intervertebral disc cells in vitro". Matrix Biology. 22 (7): 573–583. doi:10.1016/j.matbio.2003.11.008. PMID   14996437.(cited 74 times)
  7. ↑ Boyd, LM; Richardson, WJ; Allen, KD; Flahiff, C; Jing, L; Li, Y; Chen, J; Setton, LA (2008). "Early-onset degeneration of the intervertebral disc and vertebral end plate in mice deficient in type IX collagen". Arthritis Rheum. 58 (1): 164–171. doi: 10.1002/art.23231 . PMID   18163498.(cited 40 times)
  8. ↑ Allen, KD; Griffin, TM; Rodriguiz, RM; Wetsel, WC; Kraus, VB; Huebner, JL; Boyd LM; Setton, LA (2009). "Decreased physical function and increased pain sensitivity in mice deficient for type IX collagen". Arthritis Rheum. 60 (9): 2684–2693. doi:10.1002/art.24783. PMC   2760314 . PMID   19714629.(cited 29 times)
  9. ↑ Nettles, DL; Chilkoti, A; Setton, LA (2010). "Applications of elastin-like polypeptides in tissue engineering". Adv Drug Deliv Rev. 62 (15): 1479–1485. doi:10.1016/j.addr.2010.04.002. PMC   2935943 . PMID   20385185.(cited 114 times)
  10. ↑ Nettles DL; Kitaoka, K; Hanson, NA; Flahiff, CM; Mata, BA; Hsu, EW; Chilkoti, A; Setton, LA (2008). "In situ crosslinking elastin-like polypeptide gels for application to articular cartilage repair in a goat osteochondral defect model". Tissue Eng Part A. 14 (7): 1133–1140. doi:10.1089/tea.2007.0245. PMC   3312393 . PMID   18433311.(cited 50times)
  11. ↑ Betre, H; Ong, SR; Guilak, F; Chilkoti, A; Fermor, B; Setton, LA (2006). "Chondrocytic differentiation of human adipose-derived adult stem cells in elastin-like polypeptide". Biomaterials. 27 (1): 91–99. doi:10.1016/j.biomaterials.2005.05.071. PMID   16023192.
  12. ↑ Nettles, DL; Vail, TP; Morgan, MT; Grinstaff, MW; Setton, LA (2004). "Photocrosslinkable hyaluronan as a scaffold for articular cartilage repair". Ann Biomed Eng. 32 (3): 391–397. doi:10.1023/b:abme.0000017552.65260.94. PMID   15095813. S2CID   1334471.
  13. ↑ Allen, KD; Adams, SB Jr; Mata, BA; Shamji, MF; Gouze, E; Jing, L; Nettles, DL; Latt, LD; Setton, LA (2010). "Gait and behavior in an IL1β-mediated model of rat knee arthritis and effects of an IL1 antagonist". Journal of Orthopaedic Research. 29 (5): 694–703. doi:10.1002/jor.21309. PMC   3100769 . PMID   21437948.
  14. ↑ Shamji, MF; Chen, J; Friedman, AH; Richardson, WJ; Chilkoti, A; Setton, LA (2008). "Synthesis and characterization of a thermally-responsive tumor necrosis factor antagonist". J Control Release. 129 (3): 179–186. doi:10.1016/j.jconrel.2008.04.021. PMC   2637771 . PMID   18547669.
  15. ↑ Shamji, MF; Betre, H; Kraus, VB; Chen, J; Chilkoti, A; Pichika, R; Masuda, K; Setton LA (2007). "Development and characterization of a fusion protein between thermally responsive elastin-like polypeptide and interleukin-1 receptor antagonist: sustained release of a local antiinflammatory therapeutic". Arthritis Rheum. 56 (11): 3650–3661. doi:10.1002/art.22952. PMID   17968946. S2CID   32108692.
  16. ↑ Betre, H; Liu, W; Zalutsky, MR; Chilkoti, A; Kraus, VB; Setton, LA (2006). "A thermally responsive biopolymer for intra-articular drug delivery". J Control Release. 115 (2): 175–182. doi:10.1016/j.jconrel.2006.07.022. PMID   16959360.
  17. ↑ Allen, KD; Shamji, MF; Mata, BA; Gabr, MA; Sinclair, SM; Schmitt, DO; Richardson, WJ; Setton LA (2011). "Kinematic and dynamic gait compensations in a rat model of lumbar radiculopathy and the effects of tumor necrosis factor-alpha antagonism". Arthritis Research & Therapy . 13 (4): R137. doi: 10.1186/ar3451 . PMC   3239380 . PMID   21871102.
  18. ↑ Google Scholar Citations for Lori Setton
  19. ↑ Duke University Graduate School (2005). "Dean's Awards for Excellence in Mentoring: Past Recipients". gradschool.duke.edu. Archived from the original on 2013-10-20. Retrieved 2013-05-22.
  20. ↑ bmes.org (2009). "BMES Fellows". Biomedical Engineering Society. Retrieved 2013-05-23.
  21. ↑ asme.org (2007). "Van C. Mow Medal Recipients". American Society of Mechanical Engineers. Retrieved 2013-05-23.
  22. ↑ "All Fellows" (PDF). ASME. 2022.
  23. ↑ www.nsf.gov (1997-10-24). "Twenty NSF-Supported Young Scientists and Engineers Receive Presidential Award". National Science Foundation. Retrieved 2013-05-25.
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