 | |
| Type | Subsidiary |
|---|---|
| Industry | Biotechnology |
| Founded | 1995 |
| Headquarters | Austin, Texas, United States, |
| Products | xMAP, xTAG, MAGPIX, Luminex 100/200, FLEXMAP 3D, NxTAG, ARIES, VERIGENE, Amnis Cellstream, Amnis FlowSight, Amnis ImageStreamX Mk II, Guava Muse, Guava easyCyte |
| Website | www |
Luminex Corporation | A DiaSorin Company is a biotechnology company which develops, manufactures and markets proprietary biological testing technologies with applications in life-sciences.
Luminex's Multi-Analyte Profiling (xMAP) technology allows simultaneous analysis of up to 500 bioassays from a small sample volume, typically a single drop of fluid, by reading biological tests on the surface of microscopic polystyrene beads called microspheres.
The xMAP technology combines this miniaturized liquid array bioassay capability with small lasers, light emitting diodes (LEDs), digital signal processors, photo detectors, charge-coupled device imaging and proprietary software to create a system offering advantages in speed, precision, flexibility and cost. The technology is currently being used within various segments of the life sciences industry, which includes the fields of drug discovery and development, and for clinical diagnostics, genetic analysis, bio-defense, food safety and biomedical research.
The Luminex MultiCode technology is used for real-time polymerase chain reaction (PCR) and multiplexed PCR assays. [1] Luminex Corporation owns 315 issued patents worldwide, including over 124 issued patents in the United States based on its multiplexing xMAP platform.
The polymerase chain reaction (PCR) is a method widely used to rapidly make millions to billions of copies of a specific DNA sample, allowing scientists to take a very small sample of DNA and amplify it to a large enough amount to study in detail. PCR was invented in 1983 by the American biochemist Kary Mullis at Cetus Corporation; Mullis and biochemist Michael Smith, who had developed other essential ways of manipulating DNA, were jointly awarded the Nobel Prize in Chemistry in 1993.
An assay is an investigative (analytic) procedure in laboratory medicine, mining, pharmacology, environmental biology and molecular biology for qualitatively assessing or quantitatively measuring the presence, amount, or functional activity of a target entity. The measured entity is often called the analyte, the measurand, or the target of the assay. The analyte can be a drug, biochemical substance, chemical element or compound, or cell in an organism or organic sample. An assay usually aims to measure an analyte's intensive property and express it in the relevant measurement unit.
An immunoassay (IA) is a biochemical test that measures the presence or concentration of a macromolecule or a small molecule in a solution through the use of an antibody (usually) or an antigen (sometimes). The molecule detected by the immunoassay is often referred to as an "analyte" and is in many cases a protein, although it may be other kinds of molecules, of different sizes and types, as long as the proper antibodies that have the required properties for the assay are developed. Analytes in biological liquids such as serum or urine are frequently measured using immunoassays for medical and research purposes.
PerkinElmer, Inc., previously styled Perkin-Elmer, is an American global corporation focused in the business areas of diagnostics, life science research, food, environmental and industrial testing. Its capabilities include detection, imaging, informatics, and service. PerkinElmer produces analytical instruments, genetic testing and diagnostic tools, medical imaging components, software, instruments, and consumables for multiple end markets.
Promega Corporation is a Madison, Wisconsin-based manufacturer of enzymes and other products for biotechnology and molecular biology with a portfolio covering the fields of genomics, protein analysis and expression, cellular analysis, drug discovery and genetic identity.
QIAGEN N.V., the global corporate headquarter of the QIAGEN group, is located in Venlo, The Netherlands. Furthermore, European, American, and Asia regional headquarters are located in respectively Hilden, Germany, Maryland United States, and Shanghai, China. QIAGEN is a provider of sample and assay technologies for molecular diagnostics, applied testing, academic and pharmaceutical research. The company operates in more than 35 offices in over 25 countries. QIAGEN's shares are listed at the NYSE and at the Frankfurt Stock Exchange in the Prime Standard. Thierry Bernard is the company's Chief Executive Officer. The main operative headquarters are located in Hilden, Germany.
bioMérieux SA is a French multinational biotechnology company founded and headquartered in Marcy-l'Étoile, France, close to Lyon. bioMérieux is present in 44 countries and serves more than 160 countries through a large network of distributors.
Point-of-care testing is defined as medical diagnostic testing at or near the point of care—that is, at the time and place of patient care. This contrasts with the historical pattern in which testing was wholly or mostly confined to the medical laboratory, which entailed sending off specimens away from the point of care and then waiting hours or days to learn the results, during which time care must continue without the desired information.
Icosagen is a biotechnology company in Estonia providing medical diagnostics services and performing custom research programs for the biopharmaceutical industry. As of March 2009, Quattromed has been renamed Icosagen AS.
Bio-Synthesis, Inc. (BSI) is a biotechnology company headquartered in Lewisville, Texas. It is a provider of custom and catalog peptides, custom oligos, antibodies, organic synthesis, and analytical services. Biomedical researchers worldwide in universities, biotech companies, private clinics, and government agencies use products from Bio-Synthesis, Inc. in studies ranging from PCR diagnostics to cancer research and the Human Genome Project.
Suspension array technology is a high throughput, large-scale, and multiplexed screening platform used in molecular biology. SAT has been widely applied to genomic and proteomic research, such as single nucleotide polymorphism (SNP) genotyping, genetic disease screening, gene expression profiling, screening drug discovery and clinical diagnosis. SAT uses microsphere beads to prepare arrays. SAT allows for the simultaneous testing of multiple gene variants through the use of these microsphere beads as each type of microsphere bead has a unique identification based on variations in optical properties, most common is fluorescent colour. As each colour and intensity of colour has a unique wavelength, beads can easily be differentiated based on their wavelength intensity. Microspheres are readily suspendable in solution and exhibit favorable kinetics during an assay. Similar to flat microarrays, an appropriate receptor molecule, such as DNA oligonucleotide probes, antibodies, or other proteins, attach themselves to the differently labeled microspheres. This produces thousands of microsphere array elements. Probe-target hybridization is usually detected by optically labeled targets, which determines the relative abundance of each target in the sample.
Wi, Inc. is an American medical device development corporation incorporated and headquartered outside of the Denver Tech Center in Centennial, CO. Wi's contract design and manufacturing services focus on commercialization of in-vitro diagnostic microfluidic disposable cartridges and instrumentation, as well as an array of therapeutic and other medical devices. Wi programs have achieved significant industry success and recognition, notably with the LifePort Kidney Transporter, a 2004 Gold Winner, and GenMark's ePlex platform, a 2017 Silver Winner of the Medical Design Excellence Awards.
Applied Food Technologies, Inc. (AFT) is a privately held corporation in Alachua, Florida that develops diagnostics needed in the seafood industry and runs fee-for-service species identification and verification programs. The DNA-based species identification diagnostics developed by AFT are used in-house and are also packaged in a kit format and sold to federal, state and private laboratories in the US, Europe and Asia. AFT has established an extensive library of taxonomically verified fish species and has developed DNA standards for these fish.
Molecular diagnostics is a collection of techniques used to analyze biological markers in the genome and proteome, and how their cells express their genes as proteins, applying molecular biology to medical testing. In medicine the technique is used to diagnose and monitor disease, detect risk, and decide which therapies will work best for individual patients, and in agricultural biosecurity similarly to monitor crop- and livestock disease, estimate risk, and decide what quarantine measures must be taken.
DiaSorin is an Italian multinational biotechnology company that produces and markets in vitro diagnostics reagent kits used in immunodiagnostics and molecular diagnostics and since July 2021, it is also active in the Life Science business. The group was founded in 2000 and is headquartered in Saluggia, Italy. Its production is at several plants located in Europe and the United States: Saluggia and Gerenzano (Italy), Dietzenbach (Germany), Stillwater, Minnesota (US), Dartford (UK). Following the acquisition of Luminex, the company acquired five additional production plants located in the USA and in Canada (Toronto). The company is a constituent of the FTSE MIB index.
Ayoxxa Biosystems is a biotechnology company founded in 2010 in Singapore, and headquartered in Germany.
Multiplexed point-of-care testing (xPOCT) is a more complex form of point-of-care testing (POCT), or bedside testing. Point-of-care testing is designed to provide diagnostic tests at or near the time and place that the patient is admitted. POCT uses the concentrations of analytes to provide the user with information on the physiological state of the patient. An analyte is a substance, chemical or biological, that is being analyzed using a certain instrument. While point-of-care testing is the quantification of one analyte from one in vitro sample, multiplexed point-of-care testing is the simultaneous on-site quantification of various analytes from a single sample.
Professor Alison Todd is holder of 18 patents, and a co-founder and chief scientific officer of SpeeDx. The company manufactures and sells tests for detecting infectious pathogens and identifying antibiotic resistance. The biomedical company, co-founded by Todd, develops diagnostic tools. Todd mentors younger scientists and entrepreneurs, as well as advocating for greater gender diversity in leaders in STEM. ‘Nearly 60 per cent of medical science and health graduates are women, but we hold only 20 per cent of senior leadership positions in the field’.
Seegene, Inc is a Korean manufacturer of in vitro diagnostic (IVD) products, particularly molecular diagnostics. Its portfolio includes a range of assays and screening products for sepsis, respiratory diseases such as influenza and respiratory syncytial virus, as well as sexually transmitted infections (STIs). It was founded in 2000. In early 2020, it began developing and distributing a range of tests for SARS-CoV-2, the virus that causes COVID-19.
