MAD2L1BP

MAD2L1BP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2QYF
Identifiers
Aliases	MAD2L1BP , CMT2, MAD2L1 binding protein
External IDs	OMIM: 618136; MGI: 1913841; HomoloGene: 11990; GeneCards: MAD2L1BP; OMA:MAD2L1BP - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p21.1 Start 43,629,540 bp [1] End 43,640,941 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 C Start 46,458,313 bp [2] End 46,464,479 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon oocyte rectum islet of Langerhans gastrocnemius muscle granulocyte monocyte left ventricle apex of heart olfactory zone of nasal mucosa Top expressed in Ileal epithelium morula morula soleus muscle fetal liver hematopoietic progenitor cell blastocyst yolk sac granulocyte sternocleidomastoid muscle temporal muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm spindle cytoskeleton nucleus nucleolus nuclear membrane Biological process regulation of exit from mitosis mitotic cell cycle checkpoint signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9587 66591 Ensembl ENSG00000124688 ENSMUSG00000034509 UniProt Q15013 Q9DCX1 RefSeq (mRNA) NM_014628 NM_001003690 NM_025649 RefSeq (protein) NP_001003690 NP_055443 NP_079925 Location (UCSC) Chr 6: 43.63 – 43.64 Mb Chr 17: 46.46 – 46.46 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

MAD2L1-binding protein is a protein that in humans is encoded by the MAD2L1BP gene. ^{[5] [6] [7]}

Function

The protein encoded by this gene was identified as a binding protein of the MAD2 mitotic arrest deficient-like 1 (MAD2/MAD2L1). MAD2 is a key component of the spindle checkpoint that delays the onset of anaphase until all the kinetochores are attached to the spindle. This protein may interact with the spindle checkpoint and coordinate cell cycle events in late mitosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. ^[7]

Interactions

MAD2L1BP has been shown to interact with TRIP13. ^{[8] [9]}

References

1. GRCh38: Ensembl release 89: ENSG00000124688 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034509 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H (Jul 1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 2 (1): 37–43. doi: 10.1093/dnares/2.1.37 . PMID   7788527.
6. Habu T, Kim SH, Weinstein J, Matsumoto T (Dec 2002). "Identification of a MAD2-binding protein, CMT2, and its role in mitosis". The EMBO Journal. 21 (23): 6419–28. doi:10.1093/emboj/cdf659. PMC   136962 . PMID   12456649.
7. "Entrez Gene: MAD2L1BP MAD2L1 binding protein".
8. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
9. Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070. S2CID   8235923.

Further reading

• Hoja MR, Wahlestedt C, Höög C (Aug 2000). "A visual intracellular classification strategy for uncharacterized human proteins". Experimental Cell Research. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID   10942595.
• Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (Oct 2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Research. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC   311163 . PMID   11591653.
• Xia G, Luo X, Habu T, Rizo J, Matsumoto T, Yu H (Aug 2004). "Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint". The EMBO Journal. 23 (15): 3133–43. doi:10.1038/sj.emboj.7600322. PMC   514937 . PMID   15257285.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070. S2CID   8235923.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Yun MY, Kim SB, Park S, Han CJ, Han YH, Yoon SH, Kim SH, Kim CM, Choi DW, Cho MH, Park GH, Lee KH (Aug 2007). "Mutation analysis of p31comet gene, a negative regulator of Mad2, in human hepatocellular carcinoma". Experimental & Molecular Medicine. 39 (4): 508–13. doi: 10.1038/emm.2007.56 . PMID   17934339.