| MARCKSL1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | MARCKSL1 , F52, MACMARCKS, MLP, MLP1, MRP, MARCKS-like 1, MARCKS like 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 602940 MGI: 97143 HomoloGene: 40748 GeneCards: MARCKSL1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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MARCKS-related protein is a protein that in humans is encoded by the MARCKSL1 gene. [5] [6]
This gene encodes a member of the myristoylated alanine-rich C-kinase substrate (MARCKS) family. MARCKS plays a role in cytoskeletal regulation, protein kinase C signaling and calmodulin signaling. The encoded protein affects the formation of adherens junctions. Alternative splicing results in multiple transcript variants. [6]
MARCKSL1 has been shown to interact with DCTN2 [7] and JNK. [8]
Cyclin-A1 is a protein that in humans is encoded by the CCNA1 gene.
RAC-gamma serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT3 gene.
Myristoylated alanine-rich C-kinase substrate is a protein that in humans is encoded by the MARCKS gene. It plays important roles in cell shape, cell motility, secretion, transmembrane transport, regulation of the cell cycle, and neural development. Recently, MARCKS has been implicated in the exocytosis of a number of vesicles and granules such as mucin and chromaffin. It is also the name of a protein family, of which MARCKS is the most studied member. They are intrinsically disordered proteins, with an acidic pH, with high proportions of alanine, glycine, proline, and glutamic acid. They are membrane-bound through a lipid anchor at the N-terminus, and a polybasic domain in the middle. They are regulated by Ca2+/calmodulin and protein kinase C. In their unphosphorylated form, they bind to actin filaments, causing them to crosslink, and sequester acidic membrane phospholipids such as PIP2.
Dynactin subunit 2 is a protein that in humans is encoded by the DCTN2 gene.
LIM domain kinase 2 is an enzyme that in humans is encoded by the LIMK2 gene.
Rho guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the ARHGEF2 gene.
H+/Cl− exchange transporter 3 is a protein that in humans is encoded by the CLCN3 gene.
Kinesin-like protein KIF20A is a protein that in humans is encoded by the KIF20A gene.
Deubiquitinating protein VCIP135 is a protein that in humans is encoded by the VCPIP1 gene.
Myotubularin-related protein 6 is a protein that in humans is encoded by the MTMR6 gene.
Cell division protein kinase 10 is an enzyme that in humans is encoded by the CDK10 gene.
Sperm-associated antigen 6 is a protein that in humans is encoded by the SPAG6 gene.
Growth hormone-inducible transmembrane protein (GHITM), also known as transmembrane BAX inhibitor motif containing protein 5 (TMBIM5), is a protein that in humans is encoded by the GHITM gene on chromosome 10. It is a member of the BAX inhibitor motif containing (TMBIM) family and localizes to the inner mitochondrial membrane (IMM), as well as the endoplasmic reticulum (ER), where it plays a role in apoptosis through mediating mitochondrial morphology and cytochrome c release. Through its apoptotic function, GHITM may be involved in tumor metastasis and innate antiviral responses.
Zinc finger protein 43 is a protein that in humans is encoded by the ZNF43 gene.
CTTNBP2 N-terminal-like protein is a protein that in humans is encoded by the CTTNBP2NL gene. It is a substrate for phosphorylation.
Neuronal-specific septin-3 is a protein that in humans is encoded by the SEPT3 gene.
Myopodin protein, also called Synaptopodin-2 is a protein that in humans is encoded by the SYNPO2 gene. Myopodin is expressed in cardiac, smooth muscle and skeletal muscle, and localizes to Z-disc structures.
Hippocalcin like 4, also known as HPCAL4, is a human gene.
DEP domain-containing mTOR-interacting protein (DEPTOR) also known as DEP domain-containing protein 6 (DEPDC6) is a protein that in humans is encoded by the DEPTOR gene.
F-box only protein 31 is a protein that in humans is encoded by the FBXO31 gene.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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