| LPCAT3 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | LPCAT3 , C3F, LPCAT, LPLAT 5, LPSAT, MBOAT5, OACT5, nessy, lysophosphatidylcholine acyltransferase 3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 611950 MGI: 1315211 HomoloGene: 14678 GeneCards: LPCAT3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| EC number | 2.3.1.23 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Lysophospholipid acyltransferase 5 is an enzyme that in humans is encoded by the LPCAT3 gene. [5] [6] [7] [8] It is homologous to other membrane-bound O-acyltransferases.
Based on the crystalographic and cryo-EM studies of its homolog in chicken (cLPCAT3), [9] humane MBOAT5 has a typical MBOAT folding as other members such as SOAT1 and DGAT1, [10] [11] and the transmembrane helices hold a "T"-shape reaction chamber allowing the co-occupancy of a lysophosphatidylcholine (lysoPC) and a long polyunsaturated acyl-CoA, such as arachidonic acyl CoA. With the assistance of catalytic residues H374 and N338, the acyl chain could be transferred from the acyl CoA to the sn-2 position of lysoPC, thereby generating a new, polyunsaturated phospholipid.
Inhibition of LPCAT3 has been found to alter the cellular lipidome and is partially protective against ferroptosis. [12]
Probable G-protein coupled receptor 162 is a protein that in humans is encoded by the GPR162 gene.
Sterol O-acyltransferase 2, also known as SOAT2, is an enzyme that in humans is encoded by the SOAT2 gene.
Peroxisomal acyl-coenzyme A oxidase 1 is an enzyme that in humans is encoded by the ACOX1 gene.
Prohibitin-2 is a protein that in humans is encoded by the PHB2 gene.
Sideroflexin-1 is a protein that in humans is encoded by the SFXN1 gene. According to Nora Kory et al., SFXN1 gene product has mitochondrial serine transporter activity.
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha is an enzyme that in humans is encoded by the AGPAT1 gene.
Glycerol-3-phosphate acyltransferase 1, mitochondrial is an enzyme that in humans is encoded by the GPAM gene.
Acyl-protein thioesterase 1 is an enzyme that in humans is encoded by the LYPLA1 gene.
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon is an enzyme that in humans is encoded by the AGPAT5 gene.
Glycine-N-acyltransferase, also known as GLYAT, is an enzyme which in humans is encoded by the GLYAT gene.
Tyrosine-protein kinase STYK1 is an enzyme that in humans is encoded by the STYK1 gene.
Probable ribosome biogenesis protein NEP1 or EMG1 is a protein that in humans is encoded by the EMG1 gene. A D86G mutation in the protein has been associated with Bowen-Conradi syndrome.
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma is an enzyme that in humans is encoded by the AGPAT3 gene.
Ectoderm-neural cortex protein 2 is a protein that in humans is encoded by the KLHL25 gene.
Peroxisomal carnitine O-octanoyltransferase is an enzyme that in humans is encoded by the CROT gene.
Fatty acyl-CoA reductase 1 is an enzyme that in humans is encoded by the FAR1 gene.
Glycerol-3-phosphate acyltransferase 3 (GPAT-3) is an enzyme that in humans is encoded by the AGPAT9 gene. GPAT-3 is also known as:
Prolyl 3-hydroxylase 3 is an enzyme that in humans is encoded by the LEPREL2 gene.
Lysophosphatidylcholines, also called lysolecithins, are a class of chemical compounds which are derived from phosphatidylcholines.
1-Lysophosphatidylcholines are a class of phospholipids that are intermediates in the metabolism of lipids. They result from the hydrolysis of an acyl group from the sn-1 position of phosphatidylcholine. They are also called 2-acyl-sn-glycero-3-phosphocholines. The synthesis of phosphatidylcholines with specific fatty acids occurs through the synthesis of 1-lysoPC. The formation of various other lipids generates 1-lysoPC as a by-product.
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