Lipidome

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The lipidome (in yellow) as a part of the metabolome and the total interactome of a cell. Metabolomics schema.png
The lipidome (in yellow) as a part of the metabolome and the total interactome of a cell.
The quantitative lipidome (on the level of lipid classes) of yeast Saccharomyces cerevisiae in different phases of growth. Flexibility of a eukaryotic lipidome - insights from yeast lipidomics-Klose, Surma 2012 fig3A.svg
The quantitative lipidome (on the level of lipid classes) of yeast Saccharomyces cerevisiae in different phases of growth.

The lipidome refers to the totality of lipids in cells. Lipids are one of the four major molecular components of biological organisms, along with proteins, sugars and nucleic acids. Lipidome is a term coined in the context of omics in modern biology, within the field of lipidomics. [2] It can be studied using mass spectrometry and bioinformatics as well as traditional lab-based methods. [3] [4] The lipidome of a cell can be subdivided into the membrane-lipidome and mediator-lipidome. [5]

Contents

The first cell lipidome to be published was that of a mouse macrophage in 2010. [6] The lipidome of the yeast Saccharomyces cerevisiae has been characterised with an estimated 95% coverage; [7] studies of the human lipidome are ongoing. [2] [6] For example, the human plasma lipidome consist of almost 600 distinct molecular species. [8] Research suggests that the lipidome of an individual may be able to indicate cancer risks associated with dietary fats, particularly breast cancer. [9] [10]

See also

References

  1. ↑ Klose, C; Surma, MA.; Gerl, MJ.; Meyenhofer, F; Shevchenko, A; Simons, K (April 2012). "Flexibility of a Eukaryotic Lipidome – Insights from Yeast Lipidomics". PLOS ONE. 7 (4) e35063. Bibcode:2012PLoSO...735063K. doi: 10.1371/journal.pone.0035063 . PMC   3329542 . PMID   22529973.
  2. 1 2 Quehenberger O, Armando AM, Brown AH, et al. (November 2010). "Lipidomics reveals a remarkable diversity of lipids in human plasma". J. Lipid Res. 51 (11): 3299–305. doi: 10.1194/jlr.M009449 . PMC   2952570 . PMID   20671299.
  3. ↑ Subramaniam S; Fahy E; Gupta S; Sud M; Byrnes R.W; Cotter D; Dinasarapu A.R; Maurya M.R (2011). "Bioinformatics and Systems Biology of the Lipidome". Chemical Reviews. 111 (10): 6452–6490. doi:10.1021/cr200295k. PMC   3383319 . PMID   21939287.
  4. ↑ Seppänen-Laakso T, Oresic M (March 2009). "How to study lipidomes". J. Mol. Endocrinol. 42 (3): 185–90. doi: 10.1677/JME-08-0150 . PMID   19060177.
  5. ↑ "Lipidomics". BioSoft. Retrieved 7 May 2011.
  6. 1 2 "First Functioning 'Lipidome' of Mouse Macrophage Described". ScienceDaily. Retrieved 7 May 2011.
  7. ↑ Ejsing CS, Sampaio JL, Surendranath V, et al. (February 2009). "Global analysis of the yeast lipidome by quantitative shotgun mass spectrometry". Proc. Natl. Acad. Sci. U.S.A. 106 (7): 2136–41. doi: 10.1073/pnas.0811700106 . PMC   2650121 . PMID   19174513.
  8. ↑ Quehenberger, Oswald; Dennis, Edward A. (2011-11-10). "The human plasma lipidome". The New England Journal of Medicine. 365 (19): 1812–1823. doi:10.1056/NEJMra1104901. ISSN   1533-4406. PMC   3412394 . PMID   22070478.
  9. ↑ Bougnoux P, Hajjaji N, Couet C (2008). "The lipidome as a composite biomarker of the modifiable part of the risk of breast cancer". Prostaglandins Leukot. Essent. Fatty Acids. 79 (3–5): 93–6. doi:10.1016/j.plefa.2008.09.004. PMID   18930643.
  10. ↑ Bougnoux P, Giraudeau B, Couet C (March 2006). "Diet, cancer, and the lipidome". Cancer Epidemiol. Biomarkers Prev. 15 (3): 416–21. doi:10.1158/1055-9965.EPI-05-0546. PMC   2755770 . PMID   16537692.

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