MBOAT7

MBOAT7
Identifiers
Aliases	MBOAT7 , BB1, LENG4, LPIAT, LRC4, MBOA7, OACT7, hMBOA-7, membrane bound O-acyltransferase domain containing 7, MRT57, LPLAT
External IDs	OMIM: 606048; MGI: 1924832; HomoloGene: 11510; GeneCards: MBOAT7; OMA:MBOAT7 - orthologs
EC number	2.3.1.n4
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.42 Start 54,173,412 bp [1] End 54,189,882 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 A1 Start 3,680,788 bp [2] End 3,696,522 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood right adrenal gland right adrenal cortex left adrenal gland left adrenal cortex superior frontal gyrus stromal cell of endometrium right frontal lobe prefrontal cortex hypothalamus Top expressed in granulocyte ventromedial nucleus dorsomedial hypothalamic nucleus central gray substance of midbrain superior frontal gyrus primary visual cortex nucleus of stria terminalis paraventricular nucleus of hypothalamus lateral hypothalamus arcuate nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity acyltransferase activity protein binding 2-acylglycerol-3-phosphate O-acyltransferase activity 1-acylglycerol-3-phosphate O-acyltransferase activity lysophospholipid acyltransferase activity Cellular component integral component of membrane endoplasmic reticulum membrane membrane mitochondria associated membranes endoplasmic reticulum Biological process phosphatidylinositol acyl-chain remodeling phosphatidylinositol metabolic process ventricular system development lipid metabolism phospholipid biosynthetic process phospholipid metabolic process layer formation in cerebral cortex Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79143 77582 Ensembl ENSG00000273592 ENSG00000278519 ENSG00000274194 ENSG00000125505 ENSG00000277025 ENSG00000275118 ENSG00000276935 ENSG00000277733 ENSG00000277923 ENSG00000278322 ENSMUSG00000035596 UniProt Q96N66 Q8CHK3 RefSeq (mRNA) NM_001146056 NM_001146082 NM_001146083 NM_024298 NM_029934 RefSeq (protein) NP_001139528 NP_001139554 NP_001139555 NP_077274 NP_084210 Location (UCSC) Chr 19: 54.17 – 54.19 Mb Chr 7: 3.68 – 3.7 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Lysophospholipid acyltransferase 7 also known as membrane-bound O-acyltransferase domain-containing protein 7 (MBOAT7) is an enzyme that in humans is encoded by the MBOAT7 gene. ^[5] It is homologous to other membrane-bound O-acyltransferases. ^{[6] [7]}

Function

This gene encodes a member of the membrane-bound O-acyltransferase family of integral membrane proteins that have acyltransferase activity. The encoded protein is a lysophosphatidylinositol acyltransferase that has specificity for arachidonoyl-CoA as an acyl donor. This protein is involved in the re-acylation of phospholipids as part of the phospholipid remodeling pathway known as the Land cycle. ^{[5] [6]}

References

1. ENSG00000278519, ENSG00000274194, ENSG00000125505, ENSG00000277025, ENSG00000275118, ENSG00000276935, ENSG00000277733, ENSG00000277923, ENSG00000278322 GRCh38: Ensembl release 89: ENSG00000273592, ENSG00000278519, ENSG00000274194, ENSG00000125505, ENSG00000277025, ENSG00000275118, ENSG00000276935, ENSG00000277733, ENSG00000277923, ENSG00000278322 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035596 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Membrane bound O-acyltransferase domain containing 7".
6. Shindou H, Shimizu T (2009). "Acyl-CoA:Lysophospholipid Acyltransferases". Journal of Biological Chemistry. 284 (1): 1–5. doi: 10.1074/jbc.R800046200 . PMID   18718904.
7. Wang K, Lee CW, Sui X, Kim S, Wang S, Higgs AB, Baublis AJ, Voth GA, Lao M, Walther TC, Farese Jr RV (2023). "The structure of phosphatidylinositol remodeling MBOAT7 reveals its catalytic mechanism and enables inhibitor identification". Nature Communications. 14 (1) 3533: 3533. Bibcode:2023NatCo..14.3533W. doi: 10.1038/s41467-023-38932-5 . PMC   10267149 . PMID   37316513.

Further reading

• Wende H, Volz A, Ziegler A (July 2000). "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster". Immunogenetics. 51 (8–9): 703–13. doi:10.1007/s002510000187. PMID   10941842. S2CID   20719684.
• Lee HC, Inoue T, Imae R, Kono N, Shirae S, Matsuda S, Gengyo-Ando K, Mitani S, Arai H (March 2008). "Caenorhabditis elegans mboa-7, a member of the MBOAT family, is required for selective incorporation of polyunsaturated fatty acids into phosphatidylinositol". Mol. Biol. Cell. 19 (3): 1174–84. doi:10.1091/mbc.E07-09-0893. PMC   2262980 . PMID   18094042.
• Shindou H, Hishikawa D, Harayama T, Yuki K, Shimizu T (April 2009). "Recent progress on acyl CoA: lysophospholipid acyltransferase research". J. Lipid Res. 50 Suppl (Suppl): S46–51. doi: 10.1194/jlr.R800035-JLR200 . PMC   2674719 . PMID   18931347.
• Gijón MA, Riekhof WR, Zarini S, Murphy RC, Voelker DR (October 2008). "Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils". J. Biol. Chem. 283 (44): 30235–45. doi: 10.1074/jbc.M806194200 . PMC   2573059 . PMID   18772128.
• Fukunaga-Johnson N, Lee SW, Liebert M, Grossman HB (1996). "Molecular analysis of a gene, BB1, overexpressed in bladder and breast carcinoma". Anticancer Res. 16 (3A): 1085–90. PMID   8702217.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.