MCRS1

MCRS1
Identifiers
Aliases	MCRS1 , ICP22BP, INO80Q, MCRS2, MSP58, P78, microspherule protein 1
External IDs	OMIM: 609504 MGI: 1858420 HomoloGene: 4622 GeneCards: MCRS1
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q13.12 Start 49,556,544 bp [1] End 49,568,145 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 F1 Start 99,242,817 bp [2] End 99,251,961 bp [2]
RNA expression pattern Bgee Top expressed in left ventricle heart stomach muscle of leg renal cortex testicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function poly(U) RNA binding histone acetyltransferase activity (H4-K8 specific) histone acetyltransferase activity (H4-K5 specific) poly(G) binding GO:0001948 protein binding histone acetyltransferase activity (H4-K16 specific) telomerase inhibitor activity G-quadruplex RNA binding Cellular component nucleoplasm nucleolus histone acetyltransferase complex nucleus dendrite cytoplasm polysome perikaryon endoplasmic reticulum Ino80 complex MLL1 complex NSL complex Biological process positive regulation of protein localization to nucleolus DNA recombination regulation of transcription, DNA-templated negative regulation of telomerase activity transcription, DNA-templated histone H4-K5 acetylation cellular response to DNA damage stimulus cellular protein modification process negative regulation of telomere maintenance via telomere lengthening histone H4-K16 acetylation histone H4-K8 acetylation DNA repair protein deubiquitination chromatin organization positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10445	51812
Ensembl	ENSG00000187778	ENSMUSG00000037570
UniProt	Q96EZ8	Q99L90
RefSeq (mRNA)	NM_001012300 NM_001278341 NM_006337	NM_001164156 NM_016766
RefSeq (protein)	NP_001012300 NP_001265270 NP_006328	NP_001157628 NP_058046
Location (UCSC)	Chr 12: 49.56 – 49.57 Mb	Chr 15: 99.24 – 99.25 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Microspherule protein 1 is a protein that in humans is encoded by the MCRS1 gene. ^{[5] [6] [7]}

Interactions

MCRS1 has been shown to interact with PHC2, ^[8] Death associated protein 6, ^[9] NOL1, ^[6] PINX1 ^[10] and Telomerase reverse transcriptase. ^[10]

References

1. GRCh38: Ensembl release 89: ENSG00000187778 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037570 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bruni R, Roizman B (Nov 1998). "Herpes simplex virus 1 regulatory protein ICP22 interacts with a new cell cycle-regulated factor and accumulates in a cell cycle-dependent fashion in infected cells". Journal of Virology. 72 (11): 8525–31. doi:10.1128/JVI.72.11.8525-8531.1998. PMC   110262 . PMID   9765390.
6. Ren Y, Busch RK, Perlaky L, Busch H (May 1998). "The 58-kDa microspherule protein (MSP58), a nucleolar protein, interacts with nucleolar protein p120". European Journal of Biochemistry. 253 (3): 734–42. doi: 10.1046/j.1432-1327.1998.2530734.x . PMID   9654073.
7. "Entrez Gene: MCRS1 microspherule protein 1".
8. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
9. Lin DY, Shih HM (Jul 2002). "Essential role of the 58-kDa microspherule protein in the modulation of Daxx-dependent transcriptional repression as revealed by nucleolar sequestration". The Journal of Biological Chemistry. 277 (28): 25446–56. doi: 10.1074/jbc.M200633200 . PMID   11948183.
10. Song H, Li Y, Chen G, Xing Z, Zhao J, Yokoyama KK, Li T, Zhao M (Apr 2004). "Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length". Biochemical and Biophysical Research Communications. 316 (4): 1116–23. doi:10.1016/j.bbrc.2004.02.166. PMID   15044100.

Further reading

• Lin DY, Shih HM (Jul 2002). "Essential role of the 58-kDa microspherule protein in the modulation of Daxx-dependent transcriptional repression as revealed by nucleolar sequestration". The Journal of Biological Chemistry. 277 (28): 25446–56. doi: 10.1074/jbc.M200633200 . PMID   11948183.
• Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (Jan 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID   14667819.
• Song H, Li Y, Chen G, Xing Z, Zhao J, Yokoyama KK, Li T, Zhao M (Apr 2004). "Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length". Biochemical and Biophysical Research Communications. 316 (4): 1116–23. doi:10.1016/j.bbrc.2004.02.166. PMID   15044100.
• Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC   442147 . PMID   15231747.
• Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (Nov 2004). "Phosphoproteomic analysis of the developing mouse brain". Molecular & Cellular Proteomics. 3 (11): 1093–101. doi: 10.1074/mcp.M400085-MCP200 . PMID   15345747.
• Shimono K, Shimono Y, Shimokata K, Ishiguro N, Takahashi M (Nov 2005). "Microspherule protein 1, Mi-2beta, and RET finger protein associate in the nucleolus and up-regulate ribosomal gene transcription". The Journal of Biological Chemistry. 280 (47): 39436–47. doi: 10.1074/jbc.M507356200 . PMID   16186106.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Hirohashi Y, Wang Q, Liu Q, Du X, Zhang H, Sato N, Greene MI (Aug 2006). "p78/MCRS1 forms a complex with centrosomal protein Nde1 and is essential for cell viability". Oncogene. 25 (35): 4937–46. doi: 10.1038/sj.onc.1209500 . PMID   16547491.
• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (Apr 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi: 10.1073/pnas.0507066103 . PMC   1459365 . PMID   16565220.
• Davidovic L, Bechara E, Gravel M, Jaglin XH, Tremblay S, Sik A, Bardoni B, Khandjian EW (May 2006). "The nuclear microspherule protein 58 is a novel RNA-binding protein that interacts with fragile X mental retardation protein in polyribosomal mRNPs from neurons". Human Molecular Genetics. 15 (9): 1525–38. doi: 10.1093/hmg/ddl074 . PMID   16571602.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (Oct 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Du X, Wang Q, Hirohashi Y, Greene MI (Dec 2006). "DIPA, which can localize to the centrosome, associates with p78/MCRS1/MSP58 and acts as a repressor of gene transcription". Experimental and Molecular Pathology. 81 (3): 184–90. doi:10.1016/j.yexmp.2006.07.008. PMID   17014843.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Zhang J, Liu J, Li X, Li F, Wang L, Zhang J, Liu X, Shen L, Liu N, Deng Y, Yang A, Han H, Zhao M, Yao L (Jan 2007). "The physical and functional interaction of NDRG2 with MSP58 in cells". Biochemical and Biophysical Research Communications. 352 (1): 6–11. doi:10.1016/j.bbrc.2006.10.141. PMID   17109818.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.