PHC2

PHC2
Identifiers
Aliases	PHC2 , EDR2, HPH2, PH2, polyhomeotic homolog 2
External IDs	OMIM: 602979; MGI: 1860454; HomoloGene: 75090; GeneCards: PHC2; OMA:PHC2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p35.1 Start 33,323,623 bp [1] End 33,431,052 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4 D2.2|4 62.12 cM Start 128,548,495 bp [2] End 128,646,674 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung tibial arteries gastric mucosa tibial nerve ascending aorta left coronary artery ganglionic eminence upper lobe of left lung Descending thoracic aorta left uterine tube Top expressed in Rostral migratory stream external carotid artery internal carotid artery ventricular zone medial ganglionic eminence genital tubercle secondary oocyte zygote gray matter layer of cerebellum primary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding identical protein binding metal ion binding zinc ion binding Cellular component heterochromatin PRC1 complex PcG protein complex nucleus nucleoplasm Biological process spermatogenesis multicellular organism development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1912 54383 Ensembl ENSG00000134686 ENSMUSG00000028796 UniProt Q8IXK0 Q9QWH1 RefSeq (mRNA) NM_004427 NM_198040 NM_001330488 NM_001195083 NM_001195130 NM_018774 RefSeq (protein) NP_001317417 NP_004418 NP_932157 NP_001182012 NP_001182059 NP_061244 Location (UCSC) Chr 1: 33.32 – 33.43 Mb Chr 4: 128.55 – 128.65 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Polyhomeotic-like protein 2 is a protein that in humans is encoded by the PHC2 gene. ^{[5] [6] [7]}

Function

In Drosophila melanogaster, the 'Polycomb' group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein 'polyhomeotic' (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. ^[7]

Interactions

PHC2 has been shown to interact with MAPKAPK2, ^[8] PHC1, ^{[5] [9]} BMI1 ^[5] and MCRS1. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000134686 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028796 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gunster MJ, Satijn DP, Hamer KM, den Blaauwen JL, de Bruijn D, Alkema MJ, van Lohuizen M, van Driel R, Otte AP (Apr 1997). "Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic". Molecular and Cellular Biology. 17 (4): 2326–35. doi:10.1128/mcb.17.4.2326. PMC   232081 . PMID   9121482.
6. Tonkin E, Hagan DM, Li W, Strachan T (Oct 2002). "Identification and characterisation of novel mammalian homologues of Drosophila polyhomeoticpermits new insights into relationships between members of the polyhomeotic family". Human Genetics. 111 (4–5): 435–42. doi:10.1007/s00439-002-0814-3. PMID   12384788. S2CID   22192470.
7. "Entrez Gene: PHC2 polyhomeotic homolog 2 (Drosophila)".
8. Yannoni YM, Gaestel M, Lin LL (Apr 2004). "P66(ShcA) interacts with MAPKAP kinase 2 and regulates its activity". FEBS Letters. 564 (1–2): 205–11. doi:10.1016/S0014-5793(04)00351-5. PMID   15094067. S2CID   43606580.
9. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.

Further reading

• Satijn DP, Gunster MJ, van der Vlag J, Hamer KM, Schul W, Alkema MJ, Saurin AJ, Freemont PS, van Driel R, Otte AP (Jul 1997). "RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor". Molecular and Cellular Biology. 17 (7): 4105–13. doi:10.1128/mcb.17.7.4105. PMC   232264 . PMID   9199346.
• Gunther M, Laithier M, Brison O (Jul 2000). "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening". Molecular and Cellular Biochemistry. 210 (1–2): 131–42. doi:10.1023/A:1007177623283. PMID   10976766. S2CID   1339642.
• Levine SS, Weiss A, Erdjument-Bromage H, Shao Z, Tempst P, Kingston RE (Sep 2002). "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans". Molecular and Cellular Biology. 22 (17): 6070–8. doi:10.1128/MCB.22.17.6070-6078.2002. PMC   134016 . PMID   12167701.
• Yannoni YM, Gaestel M, Lin LL (Apr 2004). "P66(ShcA) interacts with MAPKAP kinase 2 and regulates its activity". FEBS Letters. 564 (1–2): 205–11. doi:10.1016/S0014-5793(04)00351-5. PMID   15094067. S2CID   43606580.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Wang H, Wang L, Erdjument-Bromage H, Vidal M, Tempst P, Jones RS, Zhang Y (Oct 2004). "Role of histone H2A ubiquitination in Polycomb silencing". Nature. 431 (7010): 873–8. Bibcode:2004Natur.431..873W. doi:10.1038/nature02985. PMID   15386022. S2CID   4344378.
• Voncken JW, Niessen H, Neufeld B, Rennefahrt U, Dahlmans V, Kubben N, Holzer B, Ludwig S, Rapp UR (Feb 2005). "MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1". The Journal of Biological Chemistry. 280 (7): 5178–87. doi: 10.1074/jbc.M407155200 . PMID   15563468.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070. S2CID   8235923.