NOL1

NOP2
Identifiers
Aliases	NOP2 , NOL1, NOP120, NSUN1, p120, NOP2 nucleolar protein
External IDs	OMIM: 164031 MGI: 107891 HomoloGene: 135865 GeneCards: NOP2
Gene location (Human)
Chr.	Chromosome 12 (human)
End	6,568,691 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	125,121,716 bp
RNA expression pattern
	Top expressed in
	lymph node; ; appendix; ; spleen; ; left uterine tube; ; gastrocnemius muscle; ; islet of Langerhans; ; right lobe of thyroid gland; ; anterior pituitary; ; thymus; ; left lobe of thyroid gland;
	Top expressed in
	otic placode; ; morula; ; superior surface of tongue; ; gallbladder; ; somite; ; saccule; ; yolk sac; ; primitive streak; ; crypt of lieberkuhn of small intestine; ; maxillary prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	methyltransferase activity ; transferase activity ; protein binding ; S-adenosylmethionine-dependent methyltransferase activity ; rRNA (cytosine-C5-)-methyltransferase activity ; RNA binding ;
Cellular component	nucleus ; nucleolus ; nucleoplasm ;
Biological process	rRNA processing ; methylation ; rRNA base methylation ; maturation of LSU-rRNA ; positive regulation of cell population proliferation ; regulation of transcription by RNA polymerase II ; ribosomal large subunit assembly ; regulation of signal transduction by p53 class mediator ; ribosome biogenesis ;
	Sources:Amigo / QuickGO
Orthologs
	4839
	110109
	ENSG00000111641
	ENSMUSG00000038279
	P46087
	Q922K7
	NM_001033714 ; NM_001258308 ; NM_001258309 ; NM_001258310 ; NM_006170 Contents Interactions ; References ; Further reading ;
	NM_138747
	NP_001028886 ; NP_001245237 ; NP_001245238 ; NP_001245239 ; NP_006161
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 28, 2023

Putative ribosomal RNA methyltransferase NOP2 is an enzyme that in humans is encoded by the NOP2 gene.^[5]^[6]

The protein encoded by this gene is a nucleolar antigen expressed in proliferating cells. It is not detectable in non-proliferating normal tissue but is detectable in many human tumors.^[7]

Overexpression of p120 leads to malignant transformation of 3T3 cells while treatment with antisense p120 mRNA causes the transformed cells to revert to their original non-malignant phenotype.^[8] The p120 protein displays a dramatic increase in expression at the G1/S transition suggesting that p120 regulates the cell cycle and nucleolar activity that is required for cell proliferation.^[9]

Interactions

NOL1 has been shown to interact with MCRS1.^[10]

Related Research Articles

Proliferating cell nuclear antigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for replication. PCNA is a homotrimer and achieves its processivity by encircling the DNA, where it acts as a scaffold to recruit proteins involved in DNA replication, DNA repair, chromatin remodeling and epigenetics.

Antigen Kiel 67, also known as Ki-67 or MKI67, is a protein that in humans is encoded by the MKI67 gene.

Nucleophosmin (NPM), also known as nucleolar phosphoprotein B23 or numatrin, is a protein that in humans is encoded by the NPM1 gene.

Y box binding protein 1 also known as Y-box transcription factor or nuclease-sensitive element-binding protein 1 is a protein that in humans is encoded by the YBX1 gene.

Nucleolin is a protein that in humans is encoded by the NCL gene.

p120 catenin, or simply p120, also called catenin delta-1, is a protein that in humans is encoded by the CTNND1 gene.

Probable ATP-dependent RNA helicase DDX5 also known as DEAD box protein 5 or RNA helicase p68 is an enzyme that in humans is encoded by the DDX5 gene.

Receptor-type tyrosine-protein phosphatase eta is an enzyme that in humans is encoded by the PTPRJ gene.

Rho guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the ARHGEF2 gene.

Guanine nucleotide-binding protein-like 3, also known as nucleostemin, is a protein that in humans is encoded by the GNL3 gene. It is found within the nucleolus that binds p53. Nucleostemin regulates the cell cycle and affects cell differentiation, decreasing in amount as this differentiation progresses. It is a marker for many stem cells and cancer cells.

Ribosome biogenesis protein BOP1 is a protein that in humans is encoded by the BOP1 gene. It is a WD40 repeat-containing nucleolar protein involved in rRNA processing, thereby controlling the cell cycle. It is required for the maturation of the 25S and 5.8S ribosomal RNAs. It may serve as an essential factor in ribosome formation that coordinates processing of the spacer regions in pre-rRNA.

Nucleolar RNA helicase 2 is an enzyme that in humans is encoded by the DDX21 gene.

Probable rRNA-processing protein EBP2 is a protein that in humans is encoded by the EBNA1BP2 gene.

Protein ajuba is a protein that in humans is encoded by the JUB gene.

DNA polymerase delta subunit 3 is an enzyme that in humans is encoded by the POLD3 gene. It is a component of the DNA polymerase delta complex.

Ribosomal oxygenase 2 is a protein that in humans is encoded by the RIOX2 gene.

Nucleoside diphosphate-linked moiety X motif 6 is a protein that in humans is encoded by the NUDT6 gene.

Nucleolar protein 8 is a protein that in humans is encoded by the NOL8 gene.

Putative methyltransferase NSUN5 is an enzyme that in humans is encoded by the NSUN5 gene.

Nucleolar and spindle associated protein 1 is a protein that in humans is encoded by the NUSAP1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000111641 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038279 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Baens M, Chaffanet M, Aerssens J, Cassiman JJ, Marynen P (October 1994). "Assignment of the gene for the human proliferating cell nucleolar protein P120 (NOL1) to chromosome 12p13 by fluorescence in situ hybridization and polymerase chain reaction with somatic cell hybrids". Genomics. 21 (1): 296–7. doi:10.1006/geno.1994.1267. PMID 8088812.
↑ "Entrez Gene: NOL1 nucleolar protein 1, 120kDa".
↑ Freeman JW, Busch RK, Gyorkey F, Gyorkey P, Ross BE, Busch H (1 March 1988). "Identification and characterization of a human proliferation-associated nucleolar antigen with a molecular weight of 120,000 expressed in early G1 phase". Cancer Res. 48 (5): 1244–51. PMID 3422591.
↑ Perlaky L, Valdez BC, Busch RK, Larson RG, Jhiang SM, Zhang WW, Brattain M, Busch H (January 1992). "Increased growth of NIH/3T3 cells by transfection with human p120 complementary DNA and inhibition by a p120 antisense construct". Cancer Res. 52 (2): 428–36. PMID 1728415.
↑ Fonagy A, Swiderski C, Wilson A, Bolton W, Kenyon N, Freeman JW (January 1993). "Cell cycle regulated expression of nucleolar antigen P120 in normal and transformed human fibroblasts". J. Cell. Physiol. 154 (1): 16–27. doi:10.1002/jcp.1041540104. PMID 8419402. S2CID 45238441.
↑ Ren Y, Busch RK, Perlaky L, Busch H (May 1998). "The 58-kDa microspherule protein (MSP58), a nucleolar protein, interacts with nucleolar protein p120". Eur. J. Biochem. 253 (3): 734–42. doi: 10.1046/j.1432-1327.1998.2530734.x . PMID 9654073.

Busch H (1990). "The final common pathway of cancer". Cancer Res. 50 (16): 4830–8. PMID 2199030.
Valdez BC, Perlaky L, Saijo Y, Henning D, Zhu C, Busch RK, Zhang WW, Busch H (1992). "A region of antisense RNA from human p120 cDNA with high homology to mouse p120 cDNA inhibits NIH 3T3 proliferation". Cancer Res. 52 (20): 5681–6. PMID 1394192.
Larson RG, Henning D, Haidar MA, Jhiang S, Lin WL, Zhang WW, Busch H (1990). "Genomic structure of the human proliferating cell nucleolar protein P120". Cancer Commun. 2 (2): 63–71. doi:10.3727/095535490820874704. PMID 2372471.
Fonagy A, Henning D, Jhiang S, Haidar M, Busch RK, Larson R, Valdez B, Busch H (1989). "Cloning of the cDNA and sequence of the human proliferating-cell nucleolar protein P120". Cancer Commun. 1 (4): 243–51. PMID 2576976.
Freeman JW, Busch RK, Gyorkey F, Gyorkey P, Ross BE, Busch H (1988). "Identification and characterization of a human proliferation-associated nucleolar antigen with a molecular weight of 120,000 expressed in early G1 phase". Cancer Res. 48 (5): 1244–51. PMID 3422591.
Valdez BC, Perlaky L, Henning D, Saijo Y, Chan PK, Busch H (1994). "Identification of the nuclear and nucleolar localization signals of the protein p120. Interaction with translocation protein B23". J. Biol. Chem. 269 (38): 23776–83. doi: 10.1016/S0021-9258(17)31583-1 . PMID 8089149.
Jallal B, Mossie K, Vasiloudis G, Knyazev P, Zachwieja J, Clairvoyant F, Schilling J, Ullrich A (1997). "The receptor-like protein-tyrosine phosphatase DEP-1 is constitutively associated with a 64-kDa protein serine/threonine kinase". J. Biol. Chem. 272 (18): 12158–63. doi: 10.1074/jbc.272.18.12158 . PMID 9115287.
Ren Y, Busch RK, Perlaky L, Busch H (1998). "The 58-kDa microspherule protein (MSP58), a nucleolar protein, interacts with nucleolar protein p120". Eur. J. Biochem. 253 (3): 734–42. doi: 10.1046/j.1432-1327.1998.2530734.x . PMID 9654073.
Colombo E, Marine JC, Danovi D, Falini B, Pelicci PG (2002). "Nucleophosmin regulates the stability and transcriptional activity of p53". Nat. Cell Biol. 4 (7): 529–33. doi:10.1038/ncb814. PMID 12080348. S2CID 24923289.
Holsinger LJ, Ward K, Duffield B, Zachwieja J, Jallal B (2002). "The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn)". Oncogene. 21 (46): 7067–76. doi:10.1038/sj.onc.1205858. PMID 12370829. S2CID 25745858.
Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ (2002). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617 . PMID 12429849.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.
Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi: 10.1073/pnas.0507066103 . PMC 1459365 . PMID 16565220.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000111641 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038279 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8088812-5] Baens M, Chaffanet M, Aerssens J, Cassiman JJ, Marynen P (October 1994). "Assignment of the gene for the human proliferating cell nucleolar protein P120 (NOL1) to chromosome 12p13 by fluorescence in situ hybridization and polymerase chain reaction with somatic cell hybrids". Genomics. 21 (1): 296–7. doi:10.1006/geno.1994.1267. PMID 8088812.

[entrez-6] "Entrez Gene: NOL1 nucleolar protein 1, 120kDa".

[pmid3422591-7] Freeman JW, Busch RK, Gyorkey F, Gyorkey P, Ross BE, Busch H (1 March 1988). "Identification and characterization of a human proliferation-associated nucleolar antigen with a molecular weight of 120,000 expressed in early G1 phase". Cancer Res. 48 (5): 1244–51. PMID 3422591.

[pmid1728415-8] Perlaky L, Valdez BC, Busch RK, Larson RG, Jhiang SM, Zhang WW, Brattain M, Busch H (January 1992). "Increased growth of NIH/3T3 cells by transfection with human p120 complementary DNA and inhibition by a p120 antisense construct". Cancer Res. 52 (2): 428–36. PMID 1728415.

[pmid8419402-9] Fonagy A, Swiderski C, Wilson A, Bolton W, Kenyon N, Freeman JW (January 1993). "Cell cycle regulated expression of nucleolar antigen P120 in normal and transformed human fibroblasts". J. Cell. Physiol. 154 (1): 16–27. doi:10.1002/jcp.1041540104. PMID 8419402. S2CID 45238441.

[pmid9654073-10] Ren Y, Busch RK, Perlaky L, Busch H (May 1998). "The 58-kDa microspherule protein (MSP58), a nucleolar protein, interacts with nucleolar protein p120". Eur. J. Biochem. 253 (3): 734–42. doi: 10.1046/j.1432-1327.1998.2530734.x . PMID 9654073.

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NOL1

Contents

Interactions

Related Research Articles

References

Further reading