MyoD family inhibitor is a protein that in humans is encoded by the MDFI gene. [5] [6] [7]
This protein is a transcription factor that negatively regulates other myogenic family proteins. Studies of the mouse homolog, I-mf, show that it interferes with myogenic factor function by masking nuclear localization signals and preventing DNA binding. Knockout mouse studies show defects in the formation of vertebrae and ribs that also involve cartilage formation in these structures. [7]
MDFI has been shown to interact with:
Myogenin, is a transcriptional activator encoded by the MYOG gene. Myogenin is a muscle-specific basic-helix-loop-helix (bHLH) transcription factor involved in the coordination of skeletal muscle development or myogenesis and repair. Myogenin is a member of the MyoD family of transcription factors, which also includes MyoD, Myf5, and MRF4.
Hsp70-binding protein 1 is a protein that in humans is encoded by the HSPBP1 gene.
Tripartite motif-containing protein 29 is a protein that in humans is encoded by the TRIM29 gene.
MAP/microtubule affinity-regulating kinase 3 is an enzyme that in humans is encoded by the MARK3 gene.
Eukaryotic translation initiation factor 3 subunit G (eIF3g) is a protein that in humans is encoded by the EIF3G gene.
Serine/threonine-protein kinase SRPK2 is an enzyme that in humans is encoded by the SRPK2 gene.
Poly(U)-binding-splicing factor PUF60 is a protein that in humans is encoded by the PUF60 gene.
E3 ubiquitin-protein ligase LNX is an enzyme that in humans is encoded by the LNX1 gene.
FK506-binding protein 2 is a protein that in humans is encoded by the FKBP2 gene.
Coiled-coil domain-containing protein 85B is a protein that in humans is encoded by the CCDC85B gene.
Protein LDOC1 is a protein that in humans is encoded by the LDOC1 gene.
PHD finger protein 21A is a protein that in humans is encoded by the PHF21A gene.
MAD2L1-binding protein is a protein that in humans is encoded by the MAD2L1BP gene.
Ras-related GTP-binding protein A is a protein that in humans is encoded by the RRAGA gene.
Nucleoside diphosphate kinase 3 is an enzyme that in humans is encoded by the NME3 gene.
Serpin I2 is a protein that in humans is encoded by the SERPINI2 gene.
Brain-enriched guanylate kinase-associated protein is an enzyme that in humans is encoded by the BEGAIN gene.
RUN domain-containing protein 3A is a protein that in humans is encoded by the RUNDC3A gene.
Akirin-2 is a protein that in humans is encoded by the AKIRIN2 gene.
Rab-like protein 6 is a protein that in humans is encoded by the RABL6 gene.