MyoD family inhibitor is a protein that in humans is encoded by the MDFI gene. [5] [6] [7]
MyoD family inhibitor is a protein that in humans is encoded by the MDFI gene. [5] [6] [7]
This protein is a transcription factor that negatively regulates other myogenic family proteins. Studies of the mouse homolog, I-mf, show that it interferes with myogenic factor function by masking nuclear localization signals and preventing DNA binding. Knockout mouse studies show defects in the formation of vertebrae and ribs that also involve cartilage formation in these structures. [7]
MDFI has been shown to interact with:
Myogenin, is a transcriptional activator encoded by the MYOG gene. Myogenin is a muscle-specific basic-helix-loop-helix (bHLH) transcription factor involved in the coordination of skeletal muscle development or myogenesis and repair. Myogenin is a member of the MyoD family of transcription factors, which also includes MyoD, Myf5, and MRF4.
Microspherule protein 1 is a protein that in humans is encoded by the MCRS1 gene.
Hsp70-binding protein 1 is a protein that in humans is encoded by the HSPBP1 gene.
MAP/microtubule affinity-regulating kinase 3 is an enzyme that in humans is encoded by the MARK3 gene.
Fragile X mental retardation syndrome-related protein 2 is a protein that in humans is encoded by the FXR2 gene.
Eukaryotic translation initiation factor 3 subunit G (eIF3g) is a protein that in humans is encoded by the EIF3G gene.
Poly(U)-binding-splicing factor PUF60 is a protein that in humans is encoded by the PUF60 gene.
Protein CBFA2T2 is a protein that in humans is encoded by the CBFA2T2 gene.
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L is an enzyme that in humans is encoded by the TAF6L gene.
Protein LDOC1 is a protein that in humans is encoded by the LDOC1 gene.
Platelet-activating factor acetylhydrolase IB subunit gamma is an enzyme that in humans is encoded by the PAFAH1B3 gene.
PHD finger protein 21A is a protein that in humans is encoded by the PHF21A gene.
Nucleoside diphosphate kinase 3 is an enzyme that in humans is encoded by the NME3 gene.
Serpin I2 is a protein that in humans is encoded by the SERPINI2 gene.
Brain-enriched guanylate kinase-associated protein is an enzyme that in humans is encoded by the BEGAIN gene.
GRIP and coiled-coil domain-containing protein 1 is a protein that in humans is encoded by the GCC1 gene.
RUN domain-containing protein 3A is a protein that in humans is encoded by the RUNDC3A gene.
Rab-like protein 6 is a protein that in humans is encoded by the RABL6 gene.
Chromobox protein homolog 2 is a protein that in humans is encoded by the CBX2 gene.
Myogenic factor 5 is a protein that in humans is encoded by the MYF5 gene. It is a protein with a key role in regulating muscle differentiation or myogenesis, specifically the development of skeletal muscle. Myf5 belongs to a family of proteins known as myogenic regulatory factors (MRFs). These basic helix loop helix transcription factors act sequentially in myogenic differentiation. MRF family members include Myf5, MyoD (Myf3), myogenin, and MRF4 (Myf6). This transcription factor is the earliest of all MRFs to be expressed in the embryo, where it is only markedly expressed for a few days. It functions during that time to commit myogenic precursor cells to become skeletal muscle. In fact, its expression in proliferating myoblasts has led to its classification as a determination factor. Furthermore, Myf5 is a master regulator of muscle development, possessing the ability to induce a muscle phenotype upon its forced expression in fibroblastic cells.
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