MFSD1

MFSD1
Identifiers
Aliases	MFSD1 , SMAP4, major facilitator superfamily domain containing 1, Minerva
External IDs	MGI: 1914118; HomoloGene: 11228; GeneCards: MFSD1; OMA:MFSD1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q25.32 Start 158,732,198 bp [1] End 158,829,719 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 E1 Start 67,490,074 bp [2] End 67,511,570 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte trabecular bone palpebral conjunctiva visceral pleura epithelium of nasopharynx parietal pleura gums skin of hip parotid gland gingival epithelium Top expressed in stroma of bone marrow right kidney yolk sac human kidney proximal tubule olfactory epithelium primitive streak lactiferous gland submandibular gland calvaria More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 64747 66868 Ensembl ENSG00000118855 ENSMUSG00000027775 UniProt Q9H3U5 Q9DC37 RefSeq (mRNA) NM_001167903 NM_001289406 NM_001289407 NM_022736 NM_025813 RefSeq (protein) NP_001161375 NP_001276335 NP_001276336 NP_073573 NP_080089 Location (UCSC) Chr 3: 158.73 – 158.83 Mb Chr 3: 67.49 – 67.51 Mb PubMed search [3] [4]
Wikidata
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Major facilitator superfamily domain containing 1 (MFSD1, SMAP) is a protein belonging to the MFS Pfam clan. ^[5] It is an Atypical solute carrier. ^[6]

It belongs to the major facilitator superfamily MFS Pfam Clan. MFSD1 has been identified in neuronal plasma membranes ^[6] and lysosomes. ^{[7] [8]}

MFSD1 belongs to AMTF6. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000118855 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027775 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Perland E, Fredriksson R (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID   27939446.
6. Perland E, Hellsten SV, Lekholm E, Eriksson MM, Arapi V, Fredriksson R (February 2017). "The Novel Membrane-Bound Proteins MFSD1 and MFSD3 are Putative SLC Transporters Affected by Altered Nutrient Intake". Journal of Molecular Neuroscience. 61 (2): 199–214. doi:10.1007/s12031-016-0867-8. PMC   5321710 . PMID   27981419.
7. Chapel A, Kieffer-Jaquinod S, Sagné C, Verdon Q, Ivaldi C, Mellal M, Thirion J, Jadot M, Bruley C, Garin J, Gasnier B, Journet A (June 2013). "An extended proteome map of the lysosomal membrane reveals novel potential transporters". Molecular & Cellular Proteomics. 12 (6): 1572–88. doi: 10.1074/mcp.M112.021980 . PMC   3675815 . PMID   23436907.
8. Palmieri M, Impey S, Kang H, di Ronza A, Pelz C, Sardiello M, Ballabio A (October 2011). "Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways". Human Molecular Genetics. 20 (19): 3852–66. doi: 10.1093/hmg/ddr306 . PMID   21752829.
9. Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9): 170142. doi:10.1098/rsob.170142. PMC   5627054 . PMID   28878041.