MFSD7

SLC49A3
Identifiers
Aliases	SLC49A3 , LP2561, major facilitator superfamily domain containing 7, solute carrier family 49 member 3, MFSD7
External IDs	MGI: 2442629 HomoloGene: 49990 GeneCards: SLC49A3
Gene location (Human)
Chr.	Chromosome 4 (human)
End	689,441 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	108,596,966 bp
RNA expression pattern
	Top expressed in
	monocyte; ; right lobe of thyroid gland; ; minor salivary gland; ; left lobe of thyroid gland; ; body of stomach; ; skin of abdomen; ; upper lobe of left lung; ; spleen; ; right lung; ; ascending aorta;
	Top expressed in
	white adipose tissue; ; zone of skin; ; colon; ; lip; ; ileum; ; esophagus; ; jejunum; ; duodenum; ; urinary bladder; ; muscle tissue;
	More reference expression data
	n/a
Orthologs
	84179
	243197
	ENSG00000169026
	ENSMUSG00000029490
	Q6UXD7
	Q8CE47
	NM_001294341 ; NM_001294342 ; NM_032219
	NM_172883 ; NM_001359977
NP_001281270 ; NP_001281271 ; NP_115595 ; NP_001364988 ; NP_001364989 ;
	NP_001364990 ; NP_001364991
	NP_766471 ; NP_001346906
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Major facilitator superfamily domain containing 7 is a protein that in humans is encoded by the MFSD7 gene.^[5]

MFSD7is an atypical SLC,^[6]^[7] thus a predicted SLC transporter. It clusters phylogenetically to the Atypical MFS Transporter family 5(AMTF5) and the SLC49 family.

Related Research Articles

Battenin is a protein that in humans is encoded by the CLN3 gene located on chromosome 16. Battenin is not clustered into any Pfam clan, but it is included in the TCDB suggesting that it is a transporter. In humans, it belongs to the atypical SLCs due to its structural and phylogenetic similarity to other SLC transporters.

The solute carrier (SLC) group of membrane transport proteins include over 400 members organized into 66 families. Most members of the SLC group are located in the cell membrane. The SLC gene nomenclature system was originally proposed by the HUGO Gene Nomenclature Committee (HGNC) and is the basis for the official HGNC names of the genes that encode these transporters. A more general transmembrane transporter classification can be found in TCDB database.

Solute carrier family 2, facilitated glucose transporter member 6 is a protein that in humans is encoded by the SLC2A6 gene.

Major facilitator superfamily domain-containing protein 2 -- also known as sodium-dependent lysophosphatidylcholine symporter 1 -- is a protein that in humans is encoded by the MFSD2A gene. MFSD2A is a membrane transport protein that is expressed in the endothelium of the blood–brain barrier (BBB) and has an essential role in BBB formation and function. Genetic ablation of MFSD2A results in leaky BBB and increases central nervous system endothelial cell vesicular transcytosis without otherwise affecting tight junctions. MFSD2A is an atypical SLC, thus a predicted SLC transporter. It clusters phylogenetically to AMTF8.

Major facilitator superfamily domain containing 8 also called MFSD8 is a protein that in humans is encoded by the MFSD8 gene. MFSD8 is an atypical SLC, thus a predicted SLC transporter. It clusters phylogenetically to the Atypical MFS Transporter family 2 (AMTF2).

Solute carrier family 22 member 25 (SLC22A25), also known as organic anion transporter UST6, is a protein that in humans is encoded by the SLC22A25 gene.

Sodium-dependent neutral amino acid transporter B(0)AT2 is a protein that in humans is encoded by the SLC6A15 gene.

Monocarboxylate transporter 6 (MCT6) is a protein in humans that is encoded by the SLC16A5 gene.

Acetyl-coenzyme A transporter 1 also known as solute carrier family 33 member 1 (SLC33A1) is a protein that in humans is encoded by the SLC33A1 gene.

Unc-93 homolog A is a protein that in humans is encoded by the UNC93A gene.

Major facilitator superfamily domain containing 14A is a protein that in humans is encoded by the MFSD14A gene. MFSD14A is an atypical solute carrier of MFS type. HGNC:23363

Major facilitator superfamily domain containing 1 is a protein belonging to the MFS Pfam clan. It is an Atypical solute carrier.

Major facilitator superfamily domain containing 3 (MFSD3) is a protein belonging to the MFS Pfam clan. It is an Atypical solute carrier located to the neuronal plasma membrane.

Major facilitator superfamily domain containing 5 is an atypical SLC expressed in neuronal plasma membrane. It is a plausible Solute carrier transporter. It transports molybdate anions, and it interacts with GLP-1R.

Major facilitator superfamily domain containing 11 (MFSD11) is an atypical Solute carrier found in plasma membranes.

Major facilitator superfamily domain containing 14B is an atypical solute carrier of MFS type. It locates to intracellular membranes.

Atypical Solute Carrier Families are novel plausible secondary active or facilitative transporter proteins that share ancestral background with the known solute carrier families (SLCs). However, they have not been assigned a name according to the SLC root system, or been classified into any of the existing SLC families.

Major facilitator superfamily domain-containing protein 9 is a protein that in humans is encoded by the MFSD9 gene. It is a potential solute carrier, and called atypical solute carrier since it is not named according to the SLC nomenclature. It is expressed both in central and peripheral organs.

Major facilitator superfamily domain containing 4A is a protein belonging to the MFS Pfam clan. It is an atypical solute carrier, thus a plausible SLC transporter in humans. MFSD4A has been identified in both central and peripheral areas.

Major facilitator superfamily domain containing 2B is a protein that in humans is encoded by the MFSD2B gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000169026 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029490 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Major facilitator superfamily domain containing 7".
↑ Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9): 170142. doi:10.1098/rsob.170142. PMC 5627054 . PMID 28878041.
↑ Perland E, Fredriksson R (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000169026 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029490 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Major facilitator superfamily domain containing 7".

[6] Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9): 170142. doi:10.1098/rsob.170142. PMC 5627054 . PMID 28878041.

[7] Perland E, Fredriksson R (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.

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