MNAT1

MNAT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1G25
Identifiers
Aliases	MNAT1 , CAP35, MAT1, RNF66, TFB3, CDK activating kinase assembly factor, MNAT1 component of CDK activating kinase
External IDs	OMIM: 602659; MGI: 106207; HomoloGene: 1821; GeneCards: MNAT1; OMA:MNAT1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q23.1 Start 60,734,742 bp [1] End 60,969,965 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12|12 C3 Start 73,170,491 bp [2] End 73,320,762 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon muscle of thigh gastrocnemius muscle olfactory zone of nasal mucosa ventricular zone ganglionic eminence popliteal artery tibial arteries right uterine tube testicle Top expressed in tail of embryo epiblast primitive streak embryo embryo lens genital tubercle yolk sac ventricular zone mandibular prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ATP-dependent activity, acting on DNA protein N-terminus binding metal ion binding protein binding RNA polymerase II CTD heptapeptide repeat kinase activity cyclin-dependent protein serine/threonine kinase activator activity zinc ion binding Cellular component nucleoplasm nucleus cytosol transcription factor TFIIH holo complex cyclin-dependent protein kinase activating kinase holoenzyme complex Biological process termination of RNA polymerase I transcription regulation of cyclin-dependent protein serine/threonine kinase activity regulation of transcription, DNA-templated adult heart development regulation of transcription by RNA polymerase II transcription initiation from RNA polymerase I promoter transcription elongation from RNA polymerase II promoter negative regulation of apoptotic process 7-methylguanosine mRNA capping transcription by RNA polymerase II ventricular system development transcription, DNA-templated response to calcium ion cell cycle transcription-coupled nucleotide-excision repair transcription initiation from RNA polymerase II promoter cell population proliferation DNA repair positive regulation of transcription by RNA polymerase II positive regulation of smooth muscle cell proliferation protein phosphorylation nucleotide-excision repair, preincision complex assembly positive regulation of cyclin-dependent protein serine/threonine kinase activity nucleotide-excision repair protein-containing complex assembly G1/S transition of mitotic cell cycle negative regulation of DNA helicase activity G2/M transition of mitotic cell cycle transcription elongation from RNA polymerase I promoter Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4331 17420 Ensembl ENSG00000020426 ENSMUSG00000021103 UniProt P51948 P51949 RefSeq (mRNA) NM_001177963 NM_002431 NM_008612 RefSeq (protein) NP_001171434 NP_002422 NP_032638 Location (UCSC) Chr 14: 60.73 – 60.97 Mb Chr 12: 73.17 – 73.32 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CDK-activating kinase assembly factor MAT1 is an enzyme that in humans is encoded by the MNAT1 gene. ^[5]

Interactions

MNAT1 has been shown to interact with:

• Cyclin H, ^{[6] [7]}
• Cyclin-dependent kinase 7, ^{[6] [8]}
• Estrogen receptor alpha, ^[6]
• MCM7, ^[9]
• MTA1, ^[6]
• P53, ^[10] and
• POU2F1. ^[11]

References

1. GRCh38: Ensembl release 89: ENSG00000020426 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021103 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Eki T, Okumura K, Abe M, Kagotani K, Taguchi H, Murakami Y, Pan ZQ, Hanaoka F (April 1998). "Mapping of the human genes encoding cyclin H (CCNH) and the CDK-activating kinase (CAK) assembly factor MAT1 (MNAT1) to chromosome bands 5q13.3-q14 and 14q23, respectively". Genomics. 47 (1): 115–20. doi:10.1006/geno.1997.5053. PMID   9465303.
6. Talukder AH, Mishra SK, Mandal M, Balasenthil S, Mehta S, Sahin AA, Barnes CJ, Kumar R (March 2003). "MTA1 interacts with MAT1, a cyclin-dependent kinase-activating kinase complex ring finger factor, and regulates estrogen receptor transactivation functions". J. Biol. Chem. 278 (13): 11676–85. doi: 10.1074/jbc.M209570200 . PMID   12527756.
7. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
8. Yee A, Nichols MA, Wu L, Hall FL, Kobayashi R, Xiong Y (December 1995). "Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor". Cancer Res. 55 (24): 6058–62. PMID   8521393.
9. Wang Y, Xu F, Hall FL (October 2000). "The MAT1 cyclin-dependent kinase-activating kinase (CAK) assembly/targeting factor interacts physically with the MCM7 DNA licensing factor". FEBS Lett. 484 (1): 17–21. doi:10.1016/s0014-5793(00)02117-7. PMID   11056214. S2CID   44625458.
10. Ko LJ, Shieh SY, Chen X, Jayaraman L, Tamai K, Taya Y, Prives C, Pan ZQ (December 1997). "p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner". Mol. Cell. Biol. 17 (12): 7220–9. doi:10.1128/mcb.17.12.7220. PMC   232579 . PMID   9372954.
11. Inamoto S, Segil N, Pan ZQ, Kimura M, Roeder RG (November 1997). "The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors". J. Biol. Chem. 272 (47): 29852–8. doi: 10.1074/jbc.272.47.29852 . PMID   9368058.

Further reading

• Jeang KT (1998). "Tat, Tat-associated kinase, and transcription". J. Biomed. Sci. 5 (1): 24–7. doi:10.1007/BF02253352. PMID   9570510.
• Yankulov K, Bentley D (1998). "Transcriptional control: Tat cofactors and transcriptional elongation". Curr. Biol. 8 (13): R447-9. Bibcode:1998CBio....8.R447Y. doi: 10.1016/S0960-9822(98)70289-1 . PMID   9651670.
• Le Goff P, Montano MM, Schodin DJ, Katzenellenbogen BS (1994). "Phosphorylation of the human estrogen receptor. Identification of hormone-regulated sites and examination of their influence on transcriptional activity". J. Biol. Chem. 269 (6): 4458–66. doi: 10.1016/S0021-9258(17)41801-1 . PMID   8308015.
• Yee A, Nichols MA, Wu L, Hall FL, Kobayashi R, Xiong Y (1995). "Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor". Cancer Res. 55 (24): 6058–62. PMID   8521393.
• Tassan JP, Jaquenoud M, Fry AM, Frutiger S, Hughes GJ, Nigg EA (1995). "In vitro assembly of a functional human CDK7-cyclin H complex requires MAT1, a novel 36 kDa RING finger protein". EMBO J. 14 (22): 5608–17. doi:10.1002/j.1460-2075.1995.tb00248.x. PMC   394676 . PMID   8521818.
• Blau J, Xiao H, McCracken S, O'Hare P, Greenblatt J, Bentley D (1996). "Three functional classes of transcriptional activation domain". Mol. Cell. Biol. 16 (5): 2044–55. doi:10.1128/MCB.16.5.2044. PMC   231191 . PMID   8628270.
• Reardon JT, Ge H, Gibbs E, Sancar A, Hurwitz J, Pan ZQ (1996). "Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH". Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6482–7. Bibcode:1996PNAS...93.6482R. doi: 10.1073/pnas.93.13.6482 . PMC   39049 . PMID   8692841.
• Drapkin R, Le Roy G, Cho H, Akoulitchev S, Reinberg D (1996). "Human cyclin-dependent kinase-activating kinase exists in three distinct complexes". Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6488–93. Bibcode:1996PNAS...93.6488D. doi: 10.1073/pnas.93.13.6488 . PMC   39050 . PMID   8692842.
• Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science. 274 (5287): 605–10. Bibcode:1996Sci...274..605Z. doi:10.1126/science.274.5287.605. PMID   8849451. S2CID   13266489.
• Parada CA, Roeder RG (1996). "Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain". Nature. 384 (6607): 375–8. Bibcode:1996Natur.384..375P. doi:10.1038/384375a0. PMID   8934526. S2CID   4278432.
• García-Martínez LF, Ivanov D, Gaynor RB (1997). "Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes". J. Biol. Chem. 272 (11): 6951–8. doi: 10.1074/jbc.272.11.6951 . PMID   9054383.
• Marinoni JC, Roy R, Vermeulen W, Miniou P, Lutz Y, Weeda G, Seroz T, Gomez DM, Hoeijmakers JH, Egly JM (1997). "Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH". EMBO J. 16 (5): 1093–102. doi:10.1093/emboj/16.5.1093. PMC   1169708 . PMID   9118947.
• Cujec TP, Cho H, Maldonado E, Meyer J, Reinberg D, Peterlin BM (1997). "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme". Mol. Cell. Biol. 17 (4): 1817–23. doi:10.1128/mcb.17.4.1817. PMC   232028 . PMID   9121429.
• Rossignol M, Kolb-Cheynel I, Egly JM (1997). "Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH". EMBO J. 16 (7): 1628–37. doi:10.1093/emboj/16.7.1628. PMC   1169767 . PMID   9130708.
• García-Martínez LF, Mavankal G, Neveu JM, Lane WS, Ivanov D, Gaynor RB (1997). "Purification of a Tat-associated kinase reveals a TFIIH complex that modulates HIV-1 transcription". EMBO J. 16 (10): 2836–50. doi:10.1093/emboj/16.10.2836. PMC   1169892 . PMID   9184228.
• Nekhai S, Shukla RR, Kumar A (1997). "A human primary T-lymphocyte-derived human immunodeficiency virus type 1 Tat-associated kinase phosphorylates the C-terminal domain of RNA polymerase II and induces CAK activity". J. Virol. 71 (10): 7436–41. doi:10.1128/JVI.71.10.7436-7441.1997. PMC   192089 . PMID   9311822.
• Cujec TP, Okamoto H, Fujinaga K, Meyer J, Chamberlin H, Morgan DO, Peterlin BM (1997). "The HIV transactivator TAT binds to the CDK-activating kinase and activates the phosphorylation of the carboxy-terminal domain of RNA polymerase II". Genes Dev. 11 (20): 2645–57. doi:10.1101/gad.11.20.2645. PMC   316603 . PMID   9334327.
• Inamoto S, Segil N, Pan ZQ, Kimura M, Roeder RG (1997). "The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors". J. Biol. Chem. 272 (47): 29852–8. doi: 10.1074/jbc.272.47.29852 . PMID   9368058.
• Ko LJ, Shieh SY, Chen X, Jayaraman L, Tamai K, Taya Y, Prives C, Pan ZQ (1997). "p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner". Mol. Cell. Biol. 17 (12): 7220–9. doi:10.1128/mcb.17.12.7220. PMC   232579 . PMID   9372954.

External links

• Overview of all the structural information available in the PDB for UniProt : P51948 (CDK-activating kinase assembly factor MAT1) at the PDBe-KB .