MPP6

PALS2
Identifiers
Aliases	PALS2 , VAM1, membrane palmitoylated protein 6, protein associated with LIN7 2, MAGUK family member, protein associated with LIN7 2, MAGUK p55 family member, MPP6, VAM-1, p55T
External IDs	OMIM: 606959 MGI: 1927340 HomoloGene: 22976 GeneCards: PALS2
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7p15.3 Start 24,573,268 bp [1] End 24,694,193 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6 B2.3|6 24.13 cM Start 50,087,221 bp [2] End 50,175,919 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon islet of Langerhans tibia gallbladder sural nerve sperm stromal cell of endometrium gastrocnemius muscle body of pancreas ganglionic eminence Top expressed in interventricular septum medullary collecting duct seminiferous tubule temporal muscle proximal tubule spermatid otic placode spermatocyte sternocleidomastoid muscle digastric muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function PDZ domain binding protein binding Cellular component plasma membrane extracellular exosome membrane Biological process protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51678 56524 Ensembl ENSG00000105926 ENSMUSG00000038388 UniProt Q9NZW5 Q9JLB0 RefSeq (mRNA) NM_001303037 NM_016447 NM_001164733 NM_001164734 NM_008016 NM_019939 NM_001361247 NM_001361248 RefSeq (protein) NP_001289966 NP_057531 NP_001158205 NP_001158206 NP_064323 NP_001348176 NP_001348177 Location (UCSC) Chr 7: 24.57 – 24.69 Mb Chr 6: 50.09 – 50.18 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

MAGUK p55 subfamily member 6 is a protein that in humans is encoded by the MPP6 gene. ^{[5] [6] [7]}

Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains. MPP6 is a member of the p55-like MAGUK subfamily (Tseng et al., 2001).[supplied by OMIM] ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000105926 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038388 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kamberov E, Makarova O, Roh M, Liu A, Karnak D, Straight S, Margolis B (May 2000). "Molecular cloning and characterization of Pals, proteins associated with mLin-7". J Biol Chem. 275 (15): 11425–31. doi: 10.1074/jbc.275.15.11425 . PMID   10753959.
6. Tseng TC, Marfatia SM, Bryant PJ, Pack S, Zhuang Z, O'Brien JE, Lin L, Hanada T, Chishti AH (Apr 2001). "VAM-1: a new member of the MAGUK family binds to human Veli-1 through a conserved domain". Biochim Biophys Acta. 1518 (3): 249–59. doi:10.1016/s0167-4781(01)00191-9. PMID   11311936.
7. "Entrez Gene: MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)".

Further reading

• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC   2882961 . PMID   12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi: 10.1038/nature01782 . PMID   12853948.
• Leonoudakis D, Conti LR, Anderson S, et al. (2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi: 10.1074/jbc.M400285200 . PMID   15024025.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID   15592455. S2CID   7200157.