MTERF1

Last updated
MTERF1
Protein MTERF PDB 3MVA.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MTERF1 , MTERF, mitochondrial transcription termination factor 1
External IDs OMIM: 602318 MGI: 3704243 HomoloGene: 5073 GeneCards: MTERF1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001301134
NM_001301135
NM_006980

NM_001042670

RefSeq (protein)

NP_001288063
NP_001288064
NP_008911

NP_001036135

Location (UCSC) Chr 7: 91.69 – 91.88 Mb Chr 5: 4.24 – 4.25 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Mitochondrial transcription termination factor 1, also known as MTERF1, is a protein which in humans is encoded by the MTERF gene. [5] [6] [7] [8]

This gene encodes a mitochondrial transcription termination factor. This protein participates in attenuating transcription from the mitochondrial genome; this attenuation allows higher levels of expression of 16S ribosomal RNA relative to the tRNA gene downstream. The product of this gene has three leucine zipper motifs bracketed by two basic domains that are all required for DNA binding. There is evidence that, for this protein, the zippers participate in intramolecular interactions that establish the three-dimensional structure required for DNA binding. [5]

Related Research Articles

<span class="mw-page-title-main">NRF1</span> Protein-coding gene in the species Homo sapiens

Nuclear respiratory factor 1, also known as Nrf1, Nrf-1, NRF1 and NRF-1, encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor -like 1" which has an official symbol of NFE2L1.

<span class="mw-page-title-main">ATF1</span> Protein-coding gene in the species Homo sapiens

Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene.

<span class="mw-page-title-main">ATF6</span> Protein-coding gene in the species Homo sapiens

Activating transcription factor 6, also known as ATF6, is a protein that, in humans, is encoded by the ATF6 gene and is involved in the unfolded protein response.

<span class="mw-page-title-main">Activating transcription factor 2</span> Protein-coding gene in the species Homo sapiens

Activating transcription factor 2, also known as ATF2, is a protein that, in humans, is encoded by the ATF2 gene.

<span class="mw-page-title-main">CUTL1</span> Protein-coding gene in the species Homo sapiens

Cux1 is a homeodomain protein that in humans is encoded by the CUX1 gene.

<span class="mw-page-title-main">ID3 (gene)</span> Protein-coding gene in the species Homo sapiens

DNA-binding protein inhibitor ID-3 is a protein that in humans is encoded by the ID3 gene.

<span class="mw-page-title-main">CAMK1</span> Protein-coding gene in the species Homo sapiens

Calcium/calmodulin-dependent protein kinase type 1 is an enzyme that in humans is encoded by the CAMK1 gene.

<span class="mw-page-title-main">IRF9</span> Protein-coding gene in the species Homo sapiens

Interferon regulatory factor 9 is a protein that in humans is encoded by the IRF9 gene, previously known as ISGF3G.

<span class="mw-page-title-main">NFYC</span> Protein-coding gene in the species Homo sapiens

Nuclear transcription factor Y subunit gamma is a protein that in humans is encoded by the NFYC gene.

<span class="mw-page-title-main">KLF10</span> Protein-coding gene in the species Homo sapiens

Krueppel-like factor 10 is a protein that in humans is encoded by the KLF10 gene.

<span class="mw-page-title-main">ZBTB7A</span> Protein-coding gene in the species Homo sapiens

Zinc finger and BTB domain-containing protein 7A is a protein that in humans is encoded by the ZBTB7A gene.

<span class="mw-page-title-main">TRAP1</span> Protein-coding gene in the species Homo sapiens

Heat shock protein 75 kDa, mitochondrial is a protein that in humans is encoded by the TRAP1 gene.

<span class="mw-page-title-main">BDP1</span> Protein-coding gene in the species Homo sapiens

Transcription factor TFIIIB component B″ homolog also known as TFIIIB150 is a protein that in humans is encoded by the BDP1 gene.

<span class="mw-page-title-main">SRCAP</span> Protein-coding gene in the species Homo sapiens

Helicase SRCAP is an enzyme that in humans is encoded by the SRCAP gene.

<span class="mw-page-title-main">PPRC1</span> Protein-coding gene in the species Homo sapiens

Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 is a protein that in humans is encoded by the PPRC1 gene.

<span class="mw-page-title-main">MRPS22</span> Protein-coding gene in the species Homo sapiens

28S ribosomal protein S22, mitochondrial is a protein that in humans is encoded by the MRPS22 gene.

<span class="mw-page-title-main">ZNF143</span> Protein-coding gene

Zinc finger protein 143 is a protein that in humans is encoded by the ZNF143 gene.

<span class="mw-page-title-main">POLRMT</span> Protein-coding gene in the species Homo sapiens

POLRMT is a symbol of RNA polymerase mitochondrial

<span class="mw-page-title-main">UBP1</span> Protein-coding gene in the species Homo sapiens

Upstream-binding protein 1 is a protein that in humans is encoded by the UBP1 gene.

<span class="mw-page-title-main">CLCC1</span> Protein-coding gene in the species Homo sapiens

Chloride channel CLIC-like 1 also known as CLCC1 is a human gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000127989 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053178 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: MTERF mitochondrial transcription termination factor".
  6. Daga A, Micol V, Hess D, Aebersold R, Attardi G (April 1993). "Molecular characterization of the transcription termination factor from human mitochondria". J. Biol. Chem. 268 (11): 8123–30. doi: 10.1016/S0021-9258(18)53070-2 . PMID   7681833.
  7. Asin-Cayuela J, Helm M, Attardi G (April 2004). "A monomer-to-trimer transition of the human mitochondrial transcription termination factor (mTERF) is associated with a loss of in vitro activity". J. Biol. Chem. 279 (15): 15670–7. doi: 10.1074/jbc.M312537200 . PMID   14744862.
  8. Asin-Cayuela J, Schwend T, Farge G, Gustafsson CM (July 2005). "The human mitochondrial transcription termination factor (mTERF) is fully active in vitro in the non-phosphorylated form". J. Biol. Chem. 280 (27): 25499–505. doi: 10.1074/jbc.M501145200 . PMID   15899902.

Further reading