MYADM

MYADM
Identifiers
Aliases	MYADM , SB135, myeloid-associated differentiation marker, myeloid associated differentiation marker
External IDs	OMIM: 609959; MGI: 1355332; HomoloGene: 9668; GeneCards: MYADM; OMA:MYADM - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.42 Start 53,864,763 bp [1] End 53,876,435 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7 A1|7 1.92 cM Start 3,337,605 bp [2] End 3,348,958 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in saphenous vein vena cava tail of epididymis synovial joint synovial membrane left uterine tube skin of hip decidua myometrium urethra Top expressed in internal carotid artery ascending aorta Ileal epithelium Paneth cell external carotid artery semi-lunar valve aortic valve carotid body endothelial cell of lymphatic vessel tunica media of zone of aorta More reference expression data BioGPS n/a
Gene ontology Molecular function molecular function Cellular component ruffle integral component of membrane membrane raft plasma membrane membrane cell-cell junction cortical actin cytoskeleton Biological process establishment of endothelial barrier negative regulation of protein phosphorylation negative regulation of protein kinase C signaling positive regulation of substrate adhesion-dependent cell spreading cell-cell junction maintenance membrane raft organization negative regulation of heterotypic cell-cell adhesion regulation of cell-substrate adhesion negative regulation of actin filament polymerization negative regulation of gene expression positive regulation of cell migration protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 91663 50918 Ensembl ENSG00000179820 ENSMUSG00000068566 UniProt Q96S97 O35682 RefSeq (mRNA) NM_138373 NM_001020818 NM_001020819 NM_001020820 NM_001020821 NM_001290188 NM_001290189 NM_001290190 NM_001290191 NM_001290192 NM_001290193 NM_001290194 NM_001093764 NM_001093765 NM_001093766 NM_016969 RefSeq (protein) NP_001018654 NP_001018655 NP_001018656 NP_001018657 NP_001277117 NP_001277118 NP_001277119 NP_001277120 NP_001277121 NP_001277122 NP_001277123 NP_612382 NP_001087233 NP_001087234 NP_001087235 NP_058665 Location (UCSC) Chr 19: 53.86 – 53.88 Mb Chr 7: 3.34 – 3.35 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Myeloid-associated differentiation marker is a protein that in humans is encoded by the MYADM gene. ^{[5] [6] [7]} It is the receptor by which human parechovirus enters cells. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000179820 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000068566 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Pettersson M, Dannaeus K, Nilsson K, Jonsson JI (Apr 2000). "Isolation of MYADM, a novel hematopoietic-associated marker gene expressed in multipotent progenitor cells and up-regulated during myeloid differentiation". J Leukoc Biol. 67 (3): 423–31. doi: 10.1002/jlb.67.3.423 . PMID   10733104. S2CID   17794202.
6. Cui W, Yu L, He H, Chu Y, Gao J, Wan B, Tang L, Zhao S (Jun 2002). "Cloning of human myeloid-associated differentiation marker (MYADM) gene whose expression was up-regulated in NB4 cells induced by all-trans retinoic acid". Mol Biol Rep. 28 (3): 123–38. doi:10.1023/A:1015288412047. PMID   12075932. S2CID   12859378.
7. "Entrez Gene: MYADM myeloid-associated differentiation marker".
8. Qiao, Wenjie; Richards, Christopher M.; Kim, Youlim; Zengel, James R.; Ding, Siyuan; Greenberg, Harry B.; Carette, Jan E. (2024). "MYADM binds human parechovirus 1 and is essential for viral entry". Nature Communications. 15 (1): 3469. Bibcode:2024NatCo..15.3469Q. doi:10.1038/s41467-024-47825-0. PMC   11043367 . PMID   38658526.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID   15146197. S2CID   27764390.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.
• Wang Q, Li N, Wang X, et al. (2007). "Membrane protein hMYADM preferentially expressed in myeloid cells is up-regulated during differentiation of stem cells and myeloid leukemia cells". Life Sci. 80 (5): 420–9. doi:10.1016/j.lfs.2006.09.043. PMID   17097684.