Wilson played in all 15 games as a true freshman at Alabama in 2016, recording eight tackles.[3] As a sophomore in 2017, he played in 12 games with two starts and had 40 tackles and four interceptions and one touchdown.[4][5] As a junior in 2018, Wilson had 71 tackles, one sack, and two interceptions.[6] After the season, Wilson decided to forgo his senior year and enter the 2019 NFL draft.[7][8]
Wilson was selected by the Cleveland Browns in the fifth round (155th overall) in the 2019 NFL Draft.[11] In week 9 against the Denver Broncos, Wilson recorded a team high five tackles and made his first career sack on Brandon Allen in the 24-19 loss.[12] In week 15 against the Arizona Cardinals, Wilson recorded his first career interception off a pass thrown by fellow rookie Kyler Murray during the 38–24 loss.[13] As a rookie, Wilson appeared in all 16 games, and started 14 of them. He finished with one sack, 82 total tackles, one interception, seven passes defended, and one forced fumble.[14]
In the 2020 season, Wilson finished with 39 total tackles and two passes defended in 13 games, of which he started eight.[15] In the 2021 season, Wilson finished with 42 total tackles in 14 games, of which he started six.[16]
New England Patriots
On March 16, 2022, Wilson was traded to the New England Patriots in exchange for Chase Winovich.[17] In the 2022 season, he appeared in all 17 games, of which he started three. He finished with 1.5 sacks, 36 total tackles, one pass defended, and one forced fumble.[18]
On March 20, 2023, Wilson re-signed with the Patriots on a one-year contract extension.[19]
Arizona Cardinals
On March 14, 2024, Wilson signed a three-year contract with the Arizona Cardinals.[20] He started 16 games for Arizona, recording one interception, five pass deflections, one fumble recovery, three sacks, and 75 combined tackles.
Wilson began the 2025 season as one of Arizona's starting linebackers, recording one interception, six pass deflections, one forced fumble, and 60 combined tackles over eight starts. After suffering a rib injury in Week 9 against the Dallas Cowboys, he was placed on injured reserve on November 15, 2025.[21]
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Injured reserve 
