Magnesium gluconate

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Magnesium gluconate
Magnesium gluconate.svg
Names
IUPAC name
Magnesium bis[(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate]
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.020.772 OOjs UI icon edit-ltr-progressive.svg
E number E580 (acidity regulators, ...)
PubChem CID
UNII
  • InChI=1S/2C6H12O7.Mg/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;/h2*2-5,7-11H,1H2,(H,12,13);/q;;+2/p-2/t2*2-,3-,4+,5-;/m11./s1
  • [Mg+2].[O-]C(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.[O-]C(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
Properties
C12H22MgO14
Molar mass 414.599 g·mol−1
Pharmacology
A12CC03 ( WHO )
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Magnesium gluconate is a compound with formula MgC12H22O14. It is the magnesium salt of gluconic acid.

According to one study, magnesium gluconate showed the highest level of bioavailability of any magnesium salt which implies its viability as a supplement, although of the 10 salts studied, all increased magnesium levels significantly. [1] This study did not include magnesium glycinate, which is one of the most bioavailable forms of magnesium.[ citation needed ]

It has E number "E580".

Use in medicine

There are data on the pharmacological properties of magnesium gluconate. Gluconic acid is the initial substrate for the reactions of pentose phosphate path of oxidation of glucose, so it was suggested that it may affect the energy metabolism of mitochondria.[ citation needed ] In Ukraine, magnesium gluconate, together with potassium gluconate in the drug Rhythmocor is used to treat heart disease. Pilot studies have shown efficacy in various cardiac arrhythmia. [2] Whether these effects are from the influence of gluconic acid on the metabolism of the heart or from the influence of magnesium and potassium on osmotic pressure is unknown.

Related Research Articles

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Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a shiny gray solid which shares many physical and chemical properties with the other five alkaline earth metals.

In chemistry, a salt is a chemical compound consisting of an ionic assembly of positively charged cations and negatively charged anions, which results in a compound with no net electric charge. A common example is table salt, with positively charged sodium ions and negatively charged chloride ions.

Magnesium sulfate Chemical compound with formula MgSO4

Magnesium sulfate or magnesium sulphate is a chemical compound, a salt with the formula MgSO
4
, consisting of magnesium cations Mg2+
and sulfate anions SO2−
4
. It is a white crystalline solid, soluble in water but not in ethanol.

Magnesium is an essential element in biological systems. Magnesium occurs typically as the Mg2+ ion. It is an essential mineral nutrient (i.e., element) for life and is present in every cell type in every organism. For example, ATP (adenosine triphosphate), the main source of energy in cells, must bind to a magnesium ion in order to be biologically active. What is called ATP is often actually Mg-ATP. As such, magnesium plays a role in the stability of all polyphosphate compounds in the cells, including those associated with the synthesis of DNA and RNA.

Sodium benzoate Chemical compound

Sodium benzoate is the sodium salt of benzoic acid, widely used as a food preservative (with an E number of E211) and a pickling agent. It appears as a white crystalline chemical with the formula C6H5COONa.

Electrolyte imbalance Medical condition

Electrolyte imbalance, or water-electrolyte imbalance, is an abnormality in the concentration of electrolytes in the body. Electrolytes play a vital role in maintaining homeostasis in the body. They help to regulate heart and neurological function, fluid balance, oxygen delivery, acid–base balance and much more. Electrolyte imbalances can develop by consuming too little or too much electrolyte as well as excreting too little or too much electrolyte.

Potassium perchlorate Chemical compound

Potassium perchlorate is the inorganic salt with the chemical formula KClO4. Like other perchlorates, this salt is a strong oxidizer although it usually reacts very slowly with organic substances. This, usually obtained as a colorless, crystalline solid, is a common oxidizer used in fireworks, ammunition percussion caps, explosive primers, and is used variously in propellants, flash compositions, stars, and sparklers. It has been used as a solid rocket propellant, although in that application it has mostly been replaced by the higher performance ammonium perchlorate. KClO4 has the lowest solubility of the alkali metal perchlorates (1.5 g in 100 mL of water at 25 °C).

Gluconic acid Chemical compound

Gluconic acid is an organic compound with molecular formula C6H12O7 and condensed structural formula HOCH2(CHOH)4COOH. It is one of the 16 stereoisomers of 2,3,4,5,6-pentahydroxyhexanoic acid.

Water softening Removing positive ions from hard water

Water softening is the removal of calcium, magnesium, and certain other metal cations in hard water. The resulting soft water requires less soap for the same cleaning effort, as soap is not wasted bonding with calcium ions. Soft water also extends the lifetime of plumbing by reducing or eliminating scale build-up in pipes and fittings. Water softening is usually achieved using lime softening or ion-exchange resins but is increasingly being accomplished using nanofiltration or reverse osmosis membranes.

Magnesium nitrate Chemical compound

Magnesium nitrate refers to inorganic compounds with the formula Mg(NO3)2(H2O)x, where x = 6, 2, and 0. All are white solids. The anhydrous material is hygroscopic, quickly forming the hexahydrate upon standing in air. All of the salts are very soluble in both water and ethanol.

Losartan Blood pressure medication

Losartan, sold under the brand name Cozaar among others, is a medication used to treat high blood pressure (hypertension). It is also used for diabetic kidney disease, heart failure, and left ventricular enlargement. It is taken by mouth. It may be used alone or in addition to other blood pressure medication. Up to six weeks may be required for the full effects to occur.

Magnesium deficiency is an electrolyte disturbance in which there is a low level of magnesium in the body. It can result in multiple symptoms. Symptoms include tremor, poor coordination, muscle spasms, loss of appetite, personality changes, and nystagmus. Complications may include seizures or cardiac arrest such as from torsade de pointes. Those with low magnesium often have low potassium.

Iron(II) gluconate, or ferrous gluconate, is a black compound often used as an iron supplement. It is the iron(II) salt of gluconic acid. It is marketed under brand names such as Fergon, Ferralet and Simron.

Calcium gluconate Chemical compound

Calcium gluconate is a mineral supplement and medication. As a medication it is used by injection into a vein to treat low blood calcium, high blood potassium, and magnesium toxicity. Supplementation is generally only required when there is not enough calcium in the diet. Supplementation may be done to treat or prevent osteoporosis or rickets. It can also be taken by mouth but is not recommended for injection into a muscle.

Magnesium citrate Chemical compound

Magnesium citrate is a magnesium preparation in salt form with citric acid in a 1:1 ratio. The name "magnesium citrate" is ambiguous and sometimes may refer to other salts such as trimagnesium citrate which has a magnesium:citrate ratio of 3:2.

Salt substitute

A salt substitute, also known as low-sodium salt, is a low-sodium alternative to edible salt marketed to circumvent the risk of high blood pressure and cardiovascular disease associated with a high intake of sodium chloride while maintaining a similar taste.

Bittern, or nigari, is the salt solution formed when halite precipitates from seawater or brines. Bitterns contain magnesium, calcium, and potassium ions as well as chloride, sulfate, iodide, and other ions.

Magnesium aspartate, the chelated magnesium salt of aspartic acid, it is a mineral supplement.

Potassium gluconate

Potassium gluconate is the potassium salt of the conjugate base of gluconic acid. It is also referred to as 2,3,4,5,6-pentahydroxycaproic acid potassium salt, D-gluconic acid potassium salt, or potassium D-gluconate.

Magnesium salts are available as a medication in a number of formulations. They are used to treat magnesium deficiency, low blood magnesium, eclampsia, and several other conditions. Magnesium is important to health.

References

  1. Coudray, C; Rambeau, M; Feillet-Coudray, C; Gueux, E; Tressol, JC; Mazur, A; Rayssiguier, Y (2005). "Study of magnesium bioavailability from ten organic and inorganic Mg salts in Mg-depleted rats using a stable isotope approach". Magnesium Research. 18 (4): 215–23. PMID   16548135.
  2. "On Synergism of Potassium and Magnesium in Maintenance of Myocardial Function". PMID   28294893.{{cite journal}}: Cite journal requires |journal= (help)