Magnesium gluconate

Last updated
Magnesium gluconate
Magnesium gluconate.svg
Names
IUPAC name
Magnesium bis[(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate]
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.020.772 OOjs UI icon edit-ltr-progressive.svg
E number E580 (acidity regulators, ...)
PubChem CID
UNII
  • InChI=1S/2C6H12O7.Mg/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;/h2*2-5,7-11H,1H2,(H,12,13);/q;;+2/p-2/t2*2-,3-,4+,5-;/m11./s1
  • [Mg+2].[O-]C(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.[O-]C(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
Properties
C12H22MgO14
Molar mass 414.599 g·mol−1
Pharmacology
A12CC03 ( WHO )
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Magnesium gluconate is a compound with formula MgC12H22O14. It is the magnesium salt of gluconic acid.

According to one study, magnesium gluconate showed the highest level[ dubious discuss ] of bioavailability of any magnesium salt which implies its viability as a supplement, although of the 10 salts studied, all increased magnesium levels significantly.[ non-primary source needed ] [1] [ non-primary source needed ] This study did not include magnesium glycinate, which is one of the most bioavailable forms of magnesium.[ medical citation needed ]

It has E number "E580".

Use in medicine

There are data on the pharmacological properties of magnesium gluconate. Gluconic acid is the initial substrate for the reactions of pentose phosphate path of oxidation of glucose, so it was suggested that it may affect the energy metabolism of mitochondria.[ citation needed ] In Ukraine, magnesium gluconate, together with potassium gluconate in the drug Rhythmocor is used to treat heart disease. Pilot studies have shown efficacy in various cardiac arrhythmia. [2] Whether these effects are from the influence of gluconic acid on the metabolism of the heart or from the influence of magnesium and potassium on osmotic pressure is unknown.[ medical citation needed ]

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Calcium gluconate is the calcium salt of gluconic acid and is used as a mineral supplement and medication. As a medication it is used by injection into a vein to treat low blood calcium, high blood potassium, and magnesium toxicity. Supplementation is generally only required when there is not enough calcium in the diet. Supplementation may be done to treat or prevent osteoporosis or rickets. It can also be taken by mouth but is not recommended for injection into a muscle.

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<span class="mw-page-title-main">Potassium gluconate</span> Chemical compound

Potassium gluconate is the potassium salt of the conjugate base of gluconic acid. It is also referred to as 2,3,4,5,6-pentahydroxycaproic acid potassium salt, D-gluconic acid potassium salt, or potassium D-gluconate.

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References

  1. Coudray, C; Rambeau, M; Feillet-Coudray, C; Gueux, E; Tressol, JC; Mazur, A; Rayssiguier, Y (2005). "Study of magnesium bioavailability from ten organic and inorganic Mg salts in Mg-depleted rats using a stable isotope approach". Magnesium Research. 18 (4): 215–23. PMID   16548135.
  2. Gromova, O. A.; Torshin, I. Y.; Kalacheva, A. G.; Grishina, T. R. (2016). "On Synergism of Potassium and Magnesium in Maintenance of Myocardial Function". Kardiologiia. 56 (3): 73–80. doi:10.18565/cardio.2016.3.73-80. PMID   28294893.